Toxic Substances report

This paper does not address EPA plans for further implementation of sections 5 and 8 of TSCA. The agency is active in both areas. For information on future plans.refer to the most recent EPA publication of its events calendarand EPA.Office of Toxic Substances report Priorities for OTS Operation --. ... 

Kwekkeboom, J. (1996) A Model for Control of Health Hazards Resulting from Exposure to Toxic Substances (Report V-415). Wageningen, Wageningen Agricultural University, Department of Air Quality (in Dutch)... 

Slooff W, De Zwart D. 1991. The pT-value as environmental policy indicator for the exposure to toxic substances. Report nr. 719102 003. Bilthoven (NL) National Institute for Public Health and the Environment (RIVM). 

Employers Responsibilities Where Employees are Exposed to Toxic Substances Reporting Amputations or In Patient Hospitalizations Guarding Floor and Wall Openings Occupational Noise Flammable and Combustible Liquids Control of Hazardous Energy Medical Services and First Aid Powered Industrial Trucks Mechanical Power Presses Selection and Use of Work Practices (electrical)... 

Employers Responsibilities Where Employees are Exposed to Toxic Substances Reporting Amputations or In Patient Hospitahzations Confined Space Entry Bloodborne Pathogens Fall Protection... 

U.S. EPA, National Pesticide Survey Phased Report, Offiice of Water, Office of Pesticides and Toxic Substances, EPA 570/9-90-015, U.S. Govt. Printing Office, Washington, D.C., 1990. 

Toxic Constituents. The seed coat of European beechnut contains an unidentified toxic substance that makes the feeding of beechnut cake to certain farm animals ha2ardous (47). A toxic concentration (up to 4000 ppm) of barium found in some Bra2il nut kernels (30,48) has been reported to... 

All the PMBs are Hsted on the U.S. EPA s Toxic Substances Control Act NonConfidential Chemical Substances Inventory (Table 8). In the early to mid-1980s, pseudocumene, mesitylene, hemimellitene, and trimethylbenzene were coveted by TSCA Section 8(a) Preliminary Assessment Information Rule (PAIR) reporting requirements (22) and by TSCA Section 8(d) for health and safety data (23). Mesitylene is the subject of a test rule subacute oral toxicity and subchtonic oral toxicity in tats were underway in 1994 (24). The Safe Drinking Water Act (SDWA) allows monitoring for pseudocumene and mesitylene at the discretion of the State (25). Of the PMBs, only pseudocumene is subject to SARA Tide III section 313 annual release reporting (26). 

There are a multitude of governmental requirements for the manufacture and handling of isocyanates. The U.S. Environmental Protection Agency (EPA) mandates testing and risk management for TDl and MDl under Toxic Substance Control Administration (TSCA). Annual reports on emissions of both isocyanates are required by the EPA under SARA 313. 

All four butanols are registered ia the United States on the Environmental Protection Agency Toxic Substances Control Act (TSCA) Inventory, a prerequisite for the manufacture or importation for commercial sale of any chemical substance or mixture ia quantities greater than a 1000 pounds (454 kg). Additionally, the manufacture and distribution of the butanols ia the United States are regulated under the Superfund Amendments and Reauthorization Act (SARA), Section 313, which requires that anyone handling at least 10,000 pounds (4545 kg) a year of a chemical substance report to both the EPA and the state any release of that substance to the environment. 

The Toxic Substances Control Act (TSCA) was enacted in 1976 to identify and control toxic chemical ha2ards to human health and the environment. One of the main provisions of TSCA was to estabUsh and maintain an inventory of all chemicals in commerce in the United States for the purpose of regulating any of the chemicals that might pose an unreasonable risk to human health or the environment. An initial inventory of chemicals was estabhshed by requiring companies to report to the United States Environmental Protection Agency (USEPA) all substances that were imported, manufactured, processed, distributed, or disposed of in the United States. Over 50,000 chemical substances were reported. PoUowing this initial inventory, introduction of all new chemical substances requires a Premanufacturing Notification (PMN) process. To be included in the PMN are the identity of the new chemical, the estimated first year and maximum production volume, manufacture and process information, a description of proposed use, potential release to the environment, possible human exposure to the new substance, and any health or environmental test data available at the time of submission. In the 10 years that TSCA has been in effect, the USEPA has received over 10,000 PMNs and up to 10% of the submissions each year are for dyes (382)... 

Yourcompany. a nitric acid manufacturer, uses ammonia in a waste treatment system to neutralize an acidic wastewater stream containing nitric acid. The reaction of the ammonia and nitric acid produces an ammonium nitrate solution. Ammonium nitrate solution is a listed toxic substance, as are nitric acid and ammonia. Your facility otherwise uses ammonia as a reactant and manufactures ammonium nitrate solution as a byproduct. If the ammonium nitrate solution is produced in a quantity that exceeds the threshold (e.g., 25,000 pounds for 1989), the facility must report for ammonium nitrate solution. If more than 10,000 pounds of ammonia is added to the wastewater treatment system, then the facility must report (or ammonia. 

Primarily recordkeeping system for individual facilities. Includes information on chemicals and manufacturers and records of accidents and training. Chris Plus adds capability of storing and printing MSDS information and assists with the preparation of Tier I and Tier II reports and right-to-know requests. Doth systems contain database of 600 toxic substances and synonyms. 

Essential oils are known to have detrimental effects on plants. The inhibitory components have not been identified, but both alde-hydic (benzol-, citrol-, cinnamal-aldehyde) and phenolic (thymol, carvacol, apiol, safrol) constituents are suspected. Muller et al. (104) demonstrated that volatile toxic materials localized in the leaves of Salvia leucophylla, Salvia apiana, and Arthemisia californica inhibited the root growth of cucumber and oat seedlings. They speculated that in the field, toxic substances from the leaves of these plants might be deposited in dew droplets on adjacent annual plants. In a subsequent paper, Muller and Muller (105) reported that the leaves of S. leucophylla contained several volatile terpenes, and growth inhibition was attributed to camphor and cineole. 

Durham, R.W. Oliver, B.G. J. Great Lakes Res. 1983, P, 160-168. Thomas, R.L. Veik. Intemat. Verein. Limnol. 1981, 21, 1666-1680. Literature Review of the Effects of Persistent Toxic Substances on Great Lakes Biota Fitchko, J., Ed. Report to the Great Lakes Science Advisory Board, International Joint Commission, Windsor, Ontario, 1986, 256p. Allan, R.J. Symp. Biol. Hung. 1989, 38, 217-243. 

Figure 3-5 graphically depicts the information that currently exists on the health effects of methyl parathion in humans and animals by various routes of exposure. The available literature reviewed concerning the health effects of methyl parathion in humans described case reports of longer-term studies of pesticide workers and case reports of accidental or intentional ingestion of methyl parathion. The occupational exposure is believed to be via the dermal and inhalation routes. The information on human exposure is limited in that the possibility of concurrent exposure to other pesticides or other toxic substances cannot be quantified. 

ATSDR/CDC. 1990. Summary Report Subcommittee report on biological indicators of organ damage and dysfunction. Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA. 

EPA. 1989a. Data evaluation report 30-Day feeding study in rats. Office of Pesticides and Toxic Substances. Washington, DC U.S. Environmental Protection Agency. Document no. 007163. 

Pyrazolone derivatives are analgesic substances that have been known for a long time. The use of antipyrine (phenazone) and aminopyrine was sharply curtailed after their bone marrow toxicity was reported. Other derivatives, however, like phenylbutazone. 

Fourteen formulations of chemical alternatives were submitted to EPA under confidentiality and they were assessed based on numerous human health and ecotoxicity endpoints in addition to bioaccumulation potential and environmental persistence. They were also screened for potential exposure to workers, users and the aquatic environment. Where data gaps existed, EPA experts used models and chemical analogs to estimate the hazard for a particular endpoint. The literature and test data reviews were published in the final report, Environmentally Preferable Options for Furniture Fire Safety Low Density Furniture Foam . In addition, each hazard endpoint was ranked with a concern level (High, Moderate or Low) based on the criteria used by the EPA s New Chemicals Program to rate the concern level of new chemicals submitted under the Toxic Substance Control Act (TSCA). As seen in Figure 8.2, where the hazard endpoint rankings are bold, the value is based on experimental data. Where the hazard endpoints are presented in italic font, the value is estimated based on models or chemical analogs. In this way, detailed hazard information was summarized and presented in a clear and concise format. 

Registry of Toxic Effects of Chemical Substances Reportable Quantity... 

Several procedures have been reported for extraction of the suspected allelopathic agents from donor plants. Essentially all the procedures that were employed attempted to simulate the routes of entry of toxic substances into the natural environment. As shown previously, the allelopathic agents are released through leaves and roots, or escape into the environment as volatile materials. Table 3 suratBrizes the different extraction and bioassay procedures employed to isolate and detect the toxic chemicals (17). For extraction, the investigators used either the plant parts from the donor plants or the intact donor plants from which the suspected chemicals were leached through leaves, stems or roots. 

The only regulations found for organophosphate ester hydraulic fluids were for aryl phosphates. Two proposed rules for aryl phosphates address 1) exclusion from hazardous waste regulations and 2) additional testing, recordkeeping, and reporting under the Toxic Substances Control Act (TSCA). 

Ciba-Geigy. 1984e. TSCA sect. 8(d) submission no. 86-870000078. Hydrolysis report with cover letter dated 01/09/87. Washington, DC Office of Toxic Substances, U.S. Environmental Protection Agency. Microfiche no. 513263. 

A draft RI report should be produced for review by the support agency and submitted to the Agency for Toxic Substances and Disease Registry (ATSDR) for its use in preparing a health assessment and also to serve as documentation of data collection and analysis in support of the FS. The draft RI report can be prepared any time between the completion of the baseline risk assessment and the completion of the draft FS. Therefore, the draft RI report should not delay the initiation or execution of the FS. 

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