Other toxicities

Dibutyltin dichloride induced acute pancreatitis and bile duct lesions in rats, depending on dose (6 and 8 mg/kg body weight intravenously) and time (1-24 weeks) (Merkord Hennighausen, 1989 Merkord et al., 1997, 1999 Sparmann et al., 2001). The lesions in the pancreas developed into a pancreatic fibrosis, and the lesions in the liver into liver cirrhosis. A single intravenous administration of dibutyltin dichloride at 4 mg/kg body weight induced a mild interstitial pancreatitis after 2 days (Merkord et al., 2001). Repeated administration of dibutyltin dichloride (4 mg/kg body weight intravenously) to rats at intervals of 3 weeks induced acute interstitial pancreatitis and, after 9-12 weeks, a pancreatic fibrosis and liver lesions (intrahepatic bile duct hyperplasia) (Merkord et al, 2001). 

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The long-term effects of CECs and HCECs leaking into the environment have been discussed. Combustion where aU ceUular plastics can evolve smoke containing carbon monoxide and in certain cases cyanide and other toxic gases from various constituents involved in thein manufacture is also a consideration. 

Fig. 43. Schematic of a hoUow-fiber artificial kidney dialyser used to remove urea and other toxic metaboUtes from blood. Several million of these devices...

The State of New Jersey has passed a law restricting the sale and disposal of batteries (qv) containing mercury, requiring manufacturers to reduce the mercury content of each battery to 1 ppm by weight by 1995, and to estabhsh a collection program for spent batteries (14). Another New Jersey law bans the sale of products having cadmium, mercury, or other toxic materials in the packaging (14) (see Cadmiumand cadmium alloys Cadmium compounds Mercury compounds). 

Animal and Human Toxicity. The acute toxicity of lindane depends on the age, sex, and animal species, and on the route of adrninistration. The oral LD q in mice, rats, and guinea pigs is 86, 125—230, and 100—127 mg/kg, respectively. In contrast, most of the other isomers were considerably more toxic (94,95). Some of the other toxic responses caused by lindane in laboratory animals include hepato- and nephotoxicity, reproductive and embryotoxicity, mutagenicity in some short-term in vitro bioassays, and carcinogenicity (80). The mechanism of the lindane-induced response is not known. Only minimal data are available on the mammalian toxicides of hexachlorocyclopentadiene. 

Silver-brazed joints are used when temperature or the combination of temperature and pressure is beyond the range of soldered joints. They are also more reliable in the event of plant fires and are more resistant to vibration. If they are used for fluids that are flammable, toxic, or damaging to human tissue, appropriate safeguarding is required by the code. There are OSHA regulations governing the use of silver brazing alloys containing cadmium and other toxic materials. 

Other chlorinated solvents such as tetrachloroethylene or chloroform may be used in place of carbon tetrachloride. Caution The reaction of sulfur trioxide with chlorinated solvents has been reported to give phosgene and other toxic products. Adequate venting of all by-product gases is essential. 

Thermal processes are typically used for highly toxic waste or highly concentrated organic wastes. If the waste contains PCB, dioxins, or other toxic substances, incineration should be chosen in order to assure destruction. If the wastes contain greater than 1000 parts per million of halogens (chlorinated materials), it would probably be desirable to select incineration of these wastes, after consideration of other options. In any case, a material may be incinerated or used as a fuel if the heat content is greater than 8500 BTUs per pound or, if between 2500 and 8500, it may be incinerated with auxiliary fuel. The waste components of concern are halogens, alkali metals and heavy metals. 

Unrestricted use of reclaimed wastewater for drinking water, however, requires careful examination. While practically a complete barrier to viruses, bacteria, and other toxic entities that must be kept out of a potable supply, RO membranes could pose serious problems should any defect develop in their separation mechanism. Given the purity and clarity of RO-treated wastewaters, however, it might be advantageous to use RO and then subject the product to well-established disinfection procedures. 

Environmental impacts. Discharges to atmosphere (particulates and other toxic or noxious emissions), surface waters (scrubbing water), and land (furnace residues) may require extensive treatment to assure protection of the environment. 

Antibiosis Inhibition or lysis of an organism mediated by metabolic products of the antagonist these products include lytic agents, enzymes, volatile compounds, and other toxic substances. 

Heavy metals the total of chromium, lead, copper and other toxic metals expressed in mg/l. 

Neuropathic pain is initiated or caused by a primary lesion in the peripheral or central nervous system. The causative agent may be trauma, nerve-invading cancer, herpes zoster, HIV, stroke, diabetes, alcohol or other toxic substances. Neuropathic pain is refractory to most analgesic drugs. Altered sodium channel activity is characteristics of neuropathic pain states. 

Persistent activation of PPARa can induce the development of hepatocellular carcinoma in susceptible rodent species by a nongenotoxic mechanism, i.e., one that does not involve direct DNA damage by peroxisome proliferator chemicals or their metabolites. This hepatocarcinogenic response is abolished in mice deficient in PPARa, underscoring the central role of PPARa, as opposed to that of two other mammalian PPAR forms (PPARy and PPAR5), in peroxisome proliferator chemical-induced hepatocarcinogenesis. Other toxic responses, such as kidney and testicular toxicities caused by exposure to certain phthalate... 

A susceptible population will exhibit a different or enhanced response to methyl parathion than will most persons exposed to the same level of methyl parathion in the environment. Reasons may include genetic makeup, age, health and nutritional status, and exposure to other toxic substances (e g., cigarette smoke). These parameters result in reduced detoxification or excretion of methyl parathion, or compromised fimction of organs affected by methyl parathion. Populations who are at greater risk due to their imusually high exposure to methyl parathion are discussed in Section 6.7 Populations With Potentially High Exposures. 

Figure 3-5 graphically depicts the information that currently exists on the health effects of methyl parathion in humans and animals by various routes of exposure. The available literature reviewed concerning the health effects of methyl parathion in humans described case reports of longer-term studies of pesticide workers and case reports of accidental or intentional ingestion of methyl parathion. The occupational exposure is believed to be via the dermal and inhalation routes. The information on human exposure is limited in that the possibility of concurrent exposure to other pesticides or other toxic substances cannot be quantified. 

Since in vivo tests in exposed human populations would involve concomitant exposure to other toxicants, it would be difficult to assess the genotoxic potential of methyl parathion alone. Therefore, additional well-designed in vitro studies using human cell lines are needed to determine the effects of methyl parathion on various genotoxic parameters (e.g., sister chromatid exchange, chromosomal aberrations, unscheduled DNA synthesis). 

Male rats given a single oral dose of 200 mg/kg of endosulfan had myocardial hemorrhages (Terziev et al. 1974). It is not clear whether this effect was due to a direct effect of endosulfan on the heart or secondary to other toxicity such as damage occurring in response to effects of endosulfan on neural control of the heart. 

Apart from the action upon Na+ channels, p,p -DDT and its metabolites can have certain other toxic effects. It has been reported that p,p -DDT can inhibit certain ATPases (see EHC 83). In fish, the inhibition of ATPases can affect osmoregulation. 

The gas is also toxic as exemplified by Table 4.24. Furthermore, the increased respiratory rate may cause increased amounts of other toxic gases, e.g. carbon monoxide in fires, to be inhaled. 

Although Gambierdiscus toxicus was the first dinofiagellate species to be involved in the genesis of ciguateric toxins, other toxic dinofiagellates have been... 

Palytoxin is probably one of the most potent toxins known to humans. Intravenous LD q values in the sue species that have been studied are consistently less than 0.5 ig/kg. In addition, palytoxin possesses a speed of action and other pharmacologic properties that are markedly different from those exhibited by other toxic materials. For example, when injected iv or sc, palytoxin is extremely toxic yet when given po or ir, it is relatively non-toxic. It is also very interesting that the doses of palytoxin required to kill are somewhat different in anesthetized vs. unanesthetized animals. 

Although there is much controversy over using animals in tests such as these, the information is an essential part of the legal testing required when new chemicals are introduced onto the market in significant quantities. These and other toxicity test results are used to help develop Material Safety Data Sheets, establish Occupational Exposure Limits and guidelines for use of appropriate safety equipment. 

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