Chemical substances inventory

Toxic Substances Control Act, Public Law No. 469, 94th U.S. Congress Chemical Substance Inventory, U.S. Environmental Protection Agency, Office of Toxic Substances, Wasliiagton, D.C., 1975. 

All the PMBs are Hsted on the U.S. EPA s Toxic Substances Control Act NonConfidential Chemical Substances Inventory (Table 8). In the early to mid-1980s, pseudocumene, mesitylene, hemimellitene, and trimethylbenzene were coveted by TSCA Section 8(a) Preliminary Assessment Information Rule (PAIR) reporting requirements (22) and by TSCA Section 8(d) for health and safety data (23). Mesitylene is the subject of a test rule subacute oral toxicity and subchtonic oral toxicity in tats were underway in 1994 (24). The Safe Drinking Water Act (SDWA) allows monitoring for pseudocumene and mesitylene at the discretion of the State (25). Of the PMBs, only pseudocumene is subject to SARA Tide III section 313 annual release reporting (26). 

Toxic Substances Control Act, Chemical Substances Inventory further information can be obtained from Industry Assistance Office, Pesticides and Toxic Substances, Environmental Protection Agency, Washington, D.C. 

Thiophene and 3-methylthiophene are Hsted on the TSCA chemical substances inventory. Thiophene is regulated as a hazardous material under OSHA and also regulated under the Clean Air Act, Section 110, 40 CFR 60.489, but there are no exposure limits or controls set for 3-methylthiophene. Both materials are regulated under sections 311/312 of the Superfund Amendments and Reauthorization Act, 1986 (SARA), as materials with an acute health and fire hazard, and under the Resource Conservation and Recovery Act, as ignitable hazardous wastes (DOOl). 

United States Environmental Protection Agency, What is the TSCA Chemical Substance Inventory http //www.epa.gov/opptintr/newchems/pubs/invntory.htm, 2006. 

First, of all, I would like to clarify the term "new chemicals." I am referring to the TSCA definition as those chemicals not listed on the TSCA Chemical Substance Inventory and maintained on a daily basis by the Office of Toxic Substances within EPA. This is a list of all commercial chemicals - some 55,000 in all - produced in or imported into the United States during the period of 1975 through 1979. My talk this afternoon will not cover the thousands of formula changes in mixtures of chemicals which occur almost daily as industry tries to meet changing market demands. 

The TSCA chemical substances inventory is a comprehensive list of the names of all existing chemical substances, and currently contains over 70,000 existing chemicals. Information in the inventory is updated every four years. A facility must submit a premanufacture notice (PMN) prior to manufacturing or importation for any chemical substances not on the list and not excluded by the TSCA. Examples of regulated chemicals include lubricants, paints, inks, fuels, plastics, and solvents. 

Many countries have adopted chemical substance inventories in order to monitor use and evaluate exposure potential and consequences. In the case of essential oils used in many fragrance applications, these oils must be on many of these lists, New essential oils used in fragrances are subject to premanufacturing or premarketing notification (PMN). PMN... 

Commercial production of PBBs dates from 1970. By 1974 ca. 11 million lbs of hexabromobiphenyl had been manufactured and marketed under the "Firemaster" trade name (BP-6 and FF-1). Production of some PBBs wets discontinued in the late 70s, but the 1980 decabromobiphenyl production in the U.S. was still reported as more than 10,000 lb. An unspecified quantity of the hexabromobiphenyl produced by a single manufacturer is listed in the Chemical Substances Inventory of 1979 (ref. 152, footnote, p. 170). 

In the United States, the Toxic Substances Control Act (TSCA) Chemical Substances Inventory (derived from the Initial Inventory of the TSCA Chemical Substance Inventory) is a listing of chemical substances manufactured, imported, or in commercial use in the United States.27 It is not a list of toxic chemicals, since toxicity is not a criterion for inclusion in the list. It was developed in response to Section 8 (d) of the TSCA, public law 94-469, and was prepared by the U.S. EPA. 

Section 8 regulates the division between new and existing substances, the latter initially being all chemicals on the market before December 1979 and listed (according to Section 8(b)) in the TSCA Chemical Substance Inventory . The approximately... 

TSCA classifies chemicals as either existing or new . Existing chemicals are listed in the TSCA Chemical Substances Inventory (the Inventory ). Both existing and new chemicals can be covered by TSCA requirements. 

Companies that manufacture or import more than 10 000 lb of certain chemicals that are included on the TSCA Chemical Substance Inventory (primarily organics) are required to report current data on the production volume, plant site, and site-limited status of these chemicals. Reporting under the lUR takes place at 4 year intervals, which began in 1986. Certain small businesses as defined by 40 CFR 710.29 are excluded. The next round of reports will be due in 2006. 

Substances not on the Inventory or are not otherwise excluded or exempt are considered new and are subject to a premanufacture notice (PMN). Examples of exclusions would include mixtures, substances subject to another statute, impurities, by-products and nonisolated intermediates. Additional exemptions also include test marketing products, low volume products, polymer exemptions, LoREX (low release and exposure exemption), and R D substances. By statute, chemical manufacturers must notify the Agency at least 90 days before manufacturing a chemical substance that is not listed on the TSCA Chemical Substance Inventory. However, TSCA does not empower the US EPA to require routine testing of new chemicals to permit a valid evaluation of the potential risks. This has been a limitation in the overall effectiveness of the PMN process. Erequently, very little data accompanies the PMN (50% of submissions present no safety data and 90% have only an LD50 and an Ames test) however, the EPA must decide within 90 days if the submitted chemical will pose a health or environmental hazard. 

A PMN must be made to the H A, under Section 5 of TSCA, 90 d before a new chemical substance is manufactured or imported into the USA. A new substance is one not on the Chemical Substances Inventory, which is the list of existing and previously-notified substances. A notification is also required for a new use of a listed substance which is subject to a Significant New Use Rule (SNUR). Notified substances are listed in the TSCA inventory only afto- being supplied and the mandatory Notice of Commencement of Manufacture or Import is filed with the EPA. Notified substances can be placed in the confidential section of the TSCA inventory, on justified request. Howev, potential suppliers can establish from the EPA whether the substance of concern is listed and hence is not notifiable by filing a bona fide intent to manufacture or import... 

For biotechnology, the most important provision of TSCA is the section 5(a) requirement that companies notify EPA at least 90 days before beginning to manufacture or import a "new chemical substance" for commercial purposes. This reporting requirement is known as premanufacture notification or PHN. Any substance that is not listed by name on EPA s Chemical Substances Inventory or that is not "naturally occurring" is defined as "new" and therefore subject to PMN requirements. 

A dagger(t) is found next to the CASRN in the printed TSCA Inventory to indicate that a definition exists for that chemical substance. These definitions appear in Appendix A of volume 1 of the 1985 Edition of the TSCA Chemical Substances Inventory. Persons using various online versions need to be certain that they obtain any definitions that may pertain to UVCB substances of interest before they make Inventory determinations. The definitions are usually found in fields separate from the main CA names, and so may be overlooked. UVCB Substances. 3.UVCB Substances, IID. 

If a category is regulated, the category and the name of the individual regulated chemical in that category must both be included. The name should be the name that appears in Volume 1 of the EPA Chemical Substance Inventory, or its supplements ... 

Fed. Reg. 33201 (Jime 27,1995) TSCA Chemical Substance Inventory Removal of 36 Incorrectly Reported Chemical Substances from the TSCA Inventory 60 FR 33201 Inv Removals 6-27-95... 

Identification of Microorganisms Currently Listed on the TSCA Chemical Substance Inventory (Aug. 31, 1994) Microorg Listing 8-31-94... 

Source EPA Toxic Substances Control Act Chemical Substances Inventory. 

The chemical substances in the Chemical Substances Inventory contain chemical compounds which are permitted for the use by industry. New compoimds not available on this list must undergo a process established by the Environmental Protection Agency, EPA. 

Hazardous and toxic substances can be defined as those chemicals present in the workplace that are capable of causing harm (see Figure 23.6). In this definition, the term chemicals includes dusts, mixtures, and common materials such as paints, fuels, and solvents. OSHA currently regulates exposure to approximately 400 substances. The OSHA Chemical Sampling Information file contains a listing for approximately 1,500 substances. The EPA s Toxic Substance Chemical Act Chemical Substances Inventory lists information on more than 62,000 chemicals or chemical substances. Some libraries maintain files of Material Safety Data Sheets (MSDSs) for more than 100,000 substances. It is not possible at this time to address or regulate the hazards associated with each of these chemicals that can potentially be found in the workplace. 

US EPA. 2013. What Is the TSCA Chemical Substance Inventory Web page - Last... 

US EPA. 2014. TSCA Chemical Substances Inventory. File last created 02/24/2014. 

The phenols selected for testing are a series of 34 four-position derivatives the majority of which are listed in the Toxic Substances Control Act Chemical Substance Inventory. They were purchased from commercial sources (Aldrich Chemical Co., Milwaukee, Wl, U.S.A. or Pfaltz and Bauer Inc., Waterbury, CT, U.S.A.) and not repurified. Stock solutions of the individual phenols were prepared in dimethylsulfoxide (DMSO) or DMSO and water mixtures at a number of concentrations 5, 10, 25, 50, or ICO g L L The volume of stock solution added to the culture medium was limited so that DMSO did not exceed a final concentration of 0.75%. This level has no effect on Tetrahymena growth (Schultz and Cajina-Quezada 1982). 

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