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Strategy synthesis

In order to begin practicing synthesis problems, it is essential to master aU of the individual reactions covered thus far. We will begin with one-step synthesis problems and then progress to cover multistep problems. [Pg.438]

Until now, we have covered substitution reactions (S jl and Sn2), elimination reactions (El and E2), and addition reactions of alkenes. Let s quickly review what these reactions can accomplish. Substitution reactions convert one group into another  [Pg.438]

Elimination reactions can be used to convert alkyl halides or alcohols into alkenes  [Pg.438]

Addition reactions are characterized by two groups adding across a double bond  [Pg.438]

It is essential to familiarize yourself with the reagents employed for each type of addition reaction covered in this chapter. [Pg.438]

In this section, we wUl discuss some strategies for the toughest problems you can expect to see— synthesis problems. Let s begin with a quick review of the reactions we have seen earlier in this chapter. We have seen how to install many different groups on a benzene ring  [Pg.106]

Carefully look at the chart above and make sure that you know the reagents that yon would use to achieve each of these transformations. If you are not familiar with the reagents, then you will be totally unable to do synthesis problems. [Pg.106]

It would be nice if all synthesis problems were just one-step problems, like this one  [Pg.106]

Usually, however, synthesis problems require a few steps, where you must install two or more groups on a ring, like this  [Pg.106]

When deahng with snch problems, there are many considerations to keep in mind  [Pg.106]

Since the first applications in the mid-1990s comhinatorial catalysis has heen developed into a standard tool for catalyst development. Whereas before the year 2000 only limited publications dealt with high-throughput preparation and testing of catalysts the number of publications strongly increased since then and reached a level of about 150 publications per year, about 30% of them are dealing with preparation of catalysts. [Pg.219]

This review puts its focus on high-throughput preparation of heterogeneous catalysts, that is, solid-state materials that are apphed in fixed-bed reactors for gas-phase reactions and in trickle-bed or stirred-tank reactors for liquid or gas-hquid reactions, respectively. Other fields of catalysis are not discussed since very different catalytic systems are used. We refer to the following reviews for homogeneous catalysis (2, 3), where combinatorial catalysis deals mainly with variation of ligands and for electrochemical catalysis [4,5], where catalysts are prepared as arrays of thin films in electrochemical cells. [Pg.219]

The often used synonym combinatorial catalysis instead of high-throughput catalysis implies that all possible combinations of all parameters that can affect catalyst performance (precursor compounds, chemical composition, synthesis protocol, calcination,. ..) will be screened to find the best suited catalyst for the reaction. Although such strategies are used in combinatorial chemistry, it is almost impossible to adapt them to heterogeneous catalysis. [Pg.219]

Let us assume that about 50 elements from the periodic table can be part of solid catalysts. Then, 1225 combinations are possible for binary compositions, 19 600 for ternary, 230 000 for quaternary and about 10 compositions can be created for a catalyst containing 10 elements according to the formula below [6, 7]. [Pg.219]

True combinatorial strategies mean that all combinations of relevant parameters are screened. Even if fast stage I screening methods are applied the number of parameters has to be restricted to keep the number of experiments within practical limits. [Pg.220]


Developing a suitable synthesis strategy for a target compound by searching for synthesis precursors, starting materials and synthesis reactions... [Pg.542]

A significant development ia trifluoromethylpyridine synthesis strategy is the use of fluoriaated aUphatic feedstocks for the ring-constmction sequence. Examples iaclude the manufacture of the herbicide dithiopyr, utilising ethyl 4,4,4-trifluoroacetoacetate [372-31-6] CF2COCH2COOC2H (436,437). 2,3-Dichloro-5-trifluoromethylpyridine [69045-84-7], a precursor to several crop-protection chemicals (see Table 15), can be prepared by conversion of l,l,l-trichloro-2,2,2-trifluoroethane [354-58-5], CF CCl, to 2,2-dichloro-3,3,3-trifluoropropionaldehyde [82107-24-2], CF2CCI2CHO, followed by cycUzation with acrylonitrile [107-13-1] (415). [Pg.338]

Extension of the Phosphorane Route. Ample evidence of the versatihty of the phosphorane synthesis strategy is provided by the proliferation of penems that followed. Nucleophilic displacement of the acetate function of the acetoxy-azetidinone (51, R = OCOCH ) [28562-53-0] (86) provided azetidinones where R = SCOCH, SCSSC2H, and SCSOC2H, which on elaboration gave the penems (52, R = CH ) (87), (52, R = SC2H ) (88), (52, R = 0C2H ) (89). Similar treatment of 3-substituted (or disubstituted) acetoxyazetidinones allowed the synthesis of a number of 2-substituted- 6-alkyl-and 6,6-dialkylpenems (90). [Pg.9]

The details of Sheehan s convergent penicillin synthesis strategy are presented in Schemes 3-5. [Pg.45]

The essential features of the Masamune-Sharpless hexose synthesis strategy are outlined in a general way in Scheme 4. The strategy is based on the reiterative- application of a two-carbon extension cycle. One cycle comprises the following four key transformations (I) homologation of an aldehyde to an allylic alcohol (II) Sharpless asymmetric epoxidation of the allylic alcohol ... [Pg.298]

Au-W clusters. Successful cluster synthesis strategies are available. ... [Pg.533]

A dendrimer-based approach for the design of globular protein mimics using glutamic (Glu) and aspartic (Asp) acids as building blocks has been developed [151]. The preassembled Glu/Asp dendrones were attached to a 1,3-bifunctional adamantyl based on a convergent dendrimer synthesis strategy (see Fig. 28). [Pg.241]

Scheme 4.7 An example diversity-oriented synthesis strategy (taken from reference [48]). Scheme 4.7 An example diversity-oriented synthesis strategy (taken from reference [48]).
An example diversity-oriented synthesis strategy as shown in Scheme 4.14 illustrates how complex targets can be quickly synthesized from smaller molecules via combinations of... [Pg.132]

Finally, the coupling of SLCA, further evaluation criteria and multi-objective optimisation are demonstrated with the help of a second case study dealing with the improvement of synthesis strategies for ionic liquids (see Section 7.5). [Pg.249]

Cost factor. The calculation of CE is similar to current approaches of LCC analyses, again tailored to the evaluation of chemical synthesis strategies. CE includes (i) the costs of the supply of reactants, solvents and auxiliaries (ii) costs resulting from synthesis, (iii) workup, (iv) application and (v) disposal. Again, this effort is related to the molarity (or mass) of the product. [Pg.264]

Synthesis Strategy of the Solvent-Free Controlled Thermolysis... [Pg.367]

Synthesis Strategy The Sintering-Controlled Synthesis (SCS) Approach... [Pg.384]


See other pages where Strategy synthesis is mentioned: [Pg.576]    [Pg.576]    [Pg.278]    [Pg.327]    [Pg.339]    [Pg.444]    [Pg.448]    [Pg.28]    [Pg.282]    [Pg.299]    [Pg.1316]    [Pg.67]    [Pg.519]    [Pg.531]    [Pg.542]    [Pg.532]    [Pg.120]    [Pg.39]    [Pg.414]    [Pg.71]    [Pg.266]    [Pg.235]    [Pg.254]    [Pg.269]    [Pg.294]    [Pg.301]    [Pg.328]    [Pg.341]    [Pg.348]    [Pg.361]    [Pg.367]    [Pg.374]    [Pg.401]    [Pg.413]    [Pg.427]    [Pg.437]    [Pg.309]    [Pg.138]   
See also in sourсe #XX -- [ Pg.54 ]

See also in sourсe #XX -- [ Pg.46 ]




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A Non-Incremental Synthesis Strategy

Alternative Strategies for Synthesis of Compounds Based on C-Alkynyl Furan Derivatives

An Incremental Synthesis Strategy

Automated Solid-Phase Oligosaccharide Synthesis Strategy

Automated oligosaccharide synthesis solution-phase strategy

Automated synthesis strategies

Block syntheses glycosylation strategies

Catalytic Iron-mediated Synthesis through -H Activation Strategies

Chain synthesis strategy

Chemoenzymatic synthesis strategy

Conventional Hard Template Synthesis Strategy

DIVERSITY-ORIENTED SYNTHESIS OF PRIVILEGED HETEROCYCLES USING DIVERGENT STRATEGY

Desymmetrization and Enzymatic Strategies for Chiral Propargyl Alcohol Synthesis

Diversity-oriented Synthesis of Chromophores by Combinatorial Strategies and Multi-component Reactions

Diversity-oriented synthesis design strategies

Diversity-oriented synthesis synthetic strategies

Electrophilic aromatic synthesis strategies

Flame synthesis strategy

Glycochemical Synthesis: Strategies and Applications, First Edition

Glycosylation Strategies in Block Syntheses

Hierarchically synthesis strategies

Hydrothermal Synthesis Strategies

Hydroxy Functional Group Alcohols Properties, Preparation, and Strategy of Synthesis

Introduction to Strategies for Organic Synthesis, First Edition. Laurie S. Starkey

LINKER STRATEGIES IN MODERN SOLID-PHASE ORGANIC SYNTHESIS

Macrolactonization strategy macrolactone synthesis

Macrolide synthesis: synthetic strategy

Mesoporous materials synthesis strategies

Metathesis in Natural Product Synthesis: Strategies, Substrates and Catalysts. Edited by Janine Cossy

Modem Supramolecular Chemistry: Strategies for Macrocycle Synthesis

Modern organic synthesis synthetic strategy

Nanocrystal synthesis strategies

New Strategies in the Synthesis of Grafted Supports

New strategy for synthesis

New strategy in organic synthesis

Novel Strategies in Aldolase-catalyzed Synthesis of Iminosugars

Oligonucleotide synthesis, combinatorial strategies

Oligosaccharide syntheses armed-disarmed strategy

Oligosaccharide synthesis strategy

Organic synthesis strategy

Organic synthesis, enantioselective strategy

Orthogonal Strategy in Oligosaccharide Synthesis

Overview of Synthesis Strategies

Peptide synthesis, combinatorial strategies

Principles, Concepts, and Strategies of Stereoselective Synthesis

Problem-Solving Strategy Multistep Synthesis

Problem-Solving Strategy Organic Synthesis

Protecting Group Strategies in Carbohydrate Synthesis

REACTION MECHANISM AND THE STRATEGY OF SYNTHESIS

Reaction synthesis strategy

Retrosynthetic synthesis strategy

Ring Construction Strategies in Synthesis Database

Scaffold Diversity Synthesis with Branching Cascades Strategy

Self-Assembly and Noncovalent Strategy for the Synthesis of Soft-Materials

Seven-membered rings, synthesis cycloaddition strategies

Solid phase peptide synthesis basic strategies

Solid phase synthesis strategy for

Solid-Phase Organic Synthesis: Concepts, Strategies, and Applications. First Edition

Split synthesis strategy

Stepwise Logic Algorithm Synthesis Strategies

Steroid synthesis annulation strategy

Strategies and Synthesis

Strategies for Aromatic Synthesis Order of Group Substitution

Strategies for Azo Dye and Pigment Synthesis

Strategies for Enantioselective Synthesis

Strategies for One-Pot Synthesis of Oligosaccharides

Strategies for Organic Drug Synthesis and Design, Second Edition. By Daniel Lednicer

Strategies for Parallel Synthesis

Strategies for Seven-Membered Ring Synthesis

Strategies for the Rational Synthesis of Carbon Nanotubes

Strategies for the Scalable Synthesis of Quantum Dots and Related Nanodimensional Materials

Strategies of Enzymatic Synthesis

Strategy X Use of Aliphatic Nitro Compounds in Synthesis

Strategy XI Radical Reactions in Synthesis

Strategy XI Radical Reactions in Synthesis FGA and its Reverse

Strategy XIII Introduction to Ring Synthesis Saturated Heterocycles

Strategy XIV Rearrangements in Synthesis

Strategy XV The Use of Ketenes in Synthesis

Strategy XVI Pericyclic Reactions in Synthesis Special Methods for Five-Membered Rings

Strategy XVI Pericyclic Rearrangements in Synthesis Special Methods for Five-Membered Rings

Strategy and Design in Synthesis

Strategy biopolymer synthesis

Strategy design in the synthesis of atypical peptides

Strategy estrone synthesis

Strategy for Controlled Chemoenzymatic Synthesis

Strategy for synthesis

Strategy in convergent synthesis

Strategy of Synthesis

Strategy of peptide synthesis

Strategy polynucleotide synthesis

Strategy polypeptide synthesis

Strategy polysaccharide synthesis

Strategy prostaglandin synthesis

Strategy synthesis with glycosyl phosphates

Synthesis Strategies Involving Epoxides

Synthesis Strategies with Transaminases

Synthesis Synthetic strategies

Synthesis chiral template strategy

Synthesis design, general strategy

Synthesis intramolecular strategy

Synthesis of liquid crystals—strategies and methods

Synthesis search strategy

Synthesis umpolung strategy

Synthetic Strategy for Macrolide Synthesis

Tetrahydropyrans synthesis cyclization strategies

The Strategy of Organic Synthesis

The Strategy of Peptide Synthesis

Total synthesis strategy

Transaminases synthesis strategies

Zeolite synthesis strategies

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