Transaminases synthesis strategies

General synthesis strategies for transaminase-catalyzed reactions. (a) Asymmetric synthesis with transaminase, (b) Kinetic resolution with transaminase, (c) Dynamic kinetic resolution with transaminase, (d) One-pot two-step deracemization with transaminase. 

Some nonproteinogenic amino acids, produced enzymatically, are shown in Table 29.4 for example, L-homophenylalanine, a key intermediate of levetiracetam and brivaracetam applicable as antiepileptic drugs, or D-fluoroalanine, a key intermediate of antibiotics inactivating the bacterial D-alanine transaminase. In Table 29.4 a selection of proteinogenic and nonproteinogenic amino acids, the used biocatalysts, synthesis strategies, and the substrates used are listed. 

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