Organic synthesis strategy

To fully use the advantages afforded by multicomponent reaction systems in solid-phase organic synthesis, strategies in which each component is immobilized on the resin must be devised. In this way, individual components can be explored in terms of diversity without the restrictions imposed by immobilization. We have described solid-phase Mannich reactions1 of a resin-bound alkyne (see chapter 5), and we show here that the diversity of products using this chemistry can be enhanced when a different component of the reaction system is immobilized. Specifically, a secondary amine, piperazine, is bound to a resin and then treated with... 

L. P. Wyatt and S. Warren, Organic Synthesis Strategy and Control, Wiley, Chichester, 2007. 

With this in mind we introduce a new organic synthesis strategy which we refer to as genealogically directed synthesis (GDS). Simply stated the central theme of this strategy utilizes mimicry of seven key phenomena/architectural criteria invoked by Nature to initiate and sustain life. These criteria deal with the flow and transfer of molecular level information through a chemical hierarchy, be it abiotic or biological. 

Organic Synthesis Strategy and Control, Written by Paul Wyatt and Stuart Warren Copyright 2007 John Wiley Sons, Ltd... 

Organic synthesis strategy and control / Paul Wyatt and Stuart Warren, p. cm. 

Organic Chemistry, Longman, 5th edn, 1989, 6.6-6.7 gives many practical examples of the nucleophilic aromatic substitution. P. Wyatt and S. Warren, Organic Synthesis Strategy and Control, Wiley, Chichester, 2007, chapter 9. 

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