The Strategy of Organic Synthesis

The mechanism for this reaction is thought to involve initial chlorination of the hydroxy group to form an alkyl hypochlorite intermediate. An E2 elimination of HC1 from this intermediate produces the ketone  

The development of environmentally safe reagents that can be used to replace more toxic materials in organic reactions is an area that deserves and is receiving considerable research attention, especially in industrial laboratories. All chemists need to be conscious of the effect on the environment of each reaction that they run. 

A common problem that an organic chemist faces in the laboratory is the lack of availability of a compound. Perhaps the compound is needed to test as a new pharmaceutical or to test a postulated reaction mechanism. If the compound is not available from a chemical supply house, the chemist is faced with the task of synthesizing it. The first step is to check the chemical literature to determine whether anyone else has ever prepared that compound. If the compound has never been prepared or if the reported preparation is difficult or of low yield, the chemist must design a new synthesis of the compound. How does an organic chemist approach such a problem  

Some examples will help clarify this process. Suppose the target is benzyl cyclopentyl ether  

CHAPTER 10 SYNTHETIC USES OF SUBSTITUTION AND ELIMINATION REACTIONS 

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The nature of an unsaturated compound is modified by formation of a tt bond with a transition metal. Since catalytic processes in organic synthesis are often associated with conversion of unsaturated substrates, alteration of the character of free unsaturated compounds by binding to a transition metal affords a quite useful means in designing the strategy of organic synthesis. For example, the usually electron-rich and nucleophilic properties of unsaturated compounds such as alkenes are modified by formation of a tt bond with an electrophiUc metal center such as Pd(ll). 

A resource that you can use to teach yourself the strategies of organic synthesis and green chemistry not fonnd in other texts... 

Since simplest AN can be easily synthesized and can exhibit various reactivity, these compounds have attracted attention as the starting reagents for the design of important building blocks in modem strategies of organic synthesis (see,... 

The first volumes of Strategies and Tactics in Organic Synthesis served this concept well, allowing readers to get a glimpse of the story behind the story. Research is not just a matter of results, but a process through which results are obtained. In the world of organic synthesis in particular, it involves the use of tools and concepts from all branches of chemistry, as well as the incorporation of principles from the humanities, arts and philosophy. Most importantly, it involves people. 

These developments, such as bifunctionalized catalyst and multi-step reaction process using a combination of supported reagents, are very interesting as a new strategy of organic synthesis. They will contribute, as powerful tools, to the development of combinatorial and green chemistry. 

Andraos, J. (2012) The Algebra of Organic Synthesis green metrics, design strategy, route selection, and optimization, CRC Press-Taylor Francis Boca Raton. 

The selective constmction of all-carbon quaternary centers is a unique challenge within the realm of organic synthesis that has received significant attention in recent years. Many of the synthetic strategies for chiral oxindole synthesis described within this chapter rely on racemic 3-alkyl or 3-aryl oxindole precursors that are available through a manifold of well established synthetic protocols. Although the synthesis of C3 monosubstituted oxindoles will not be treated in detail within this... 

The science of organic synthesis revolves around the development of newer strategies and methodologies which are more efficient, greener, practical, and safe. Despite the fact that there has been dramatic success in the past few decades in the area of development of newer and environmentally friendly methods, one is not able to synthesize everything that is needed. In fact, in the literature there are more unconquered complex targets than already synthesized targets. There are several complex bioactive and most wanted natural products that are either conquered but not with optimum efficiency or that have never been synthesized. ... 

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