Problem-Solving Strategy Organic Synthesis

Mechanism 8-11 Olefin Metathesis 376 Problem-Solving Strategy Organic Synthesis 376 Summary Reactions of Alkenes 378 EssentialTerms 383 Study Problems 386... 

We now find ourselves familiar with methods of constructing a carbon skeleton for an organic molecule, how to introduce and transform functional groups, and how to achieve the required selectivity. One could almost expect the rich arsenal of contemporary methods to enable the chemist to solve practically any problem of synthetic chemistry. Yet it is not quite so simple. It is imperative to be skillful in planning a synthesis, to be able not only to master its tactics, but its overall strategy as well. 

Although these utilitarian reasons are often cited for a synthesis, the challenging problems usually encountered in a total synthesis provide many opportunities to find new reactions, processes, or strategies which may be of value to other organic chemists. Corey and Wipke stated a few of the u.seful applications that may be found in a retrosynthetic analysis-synthesis problem.Many of the.se may be useful in solving problems for another target or in applications to a completely different area of organic chemistry. 

Purpose. You will carry out the multistep synthesis of the epoch-making antibacterial drug, sulfanilamide.You wiU learn the techniques for handling moisture sensitive materials and investigate the strategies involved in solving a synthetic organic problem. 

The synthesis of aromatics and heteroaromatics is an important endeavor which, as for any class of organic materials, thrives on innovative strategies and economical methods to solve demanding problems in the construction of polysubstituted systems and complex molecules including natural products. From an indust perspective, tbe task is amply recognized from the ct that > 80% of today s commercial pharmaceuticals and agrochemicals embody aromatic or heteroaromatic components [7]. Aside from electrophilic substimtion, numerous methods, based on aromatics as well as non-... 

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