DIVERSITY-ORIENTED SYNTHESIS OF PRIVILEGED HETEROCYCLES USING DIVERGENT STRATEGY

DIVERSITY-ORIENTED SYNTHESIS OF PRIVILEGED HETEROCYCLES USING DIVERGENT STRATEGY 

Natural products have been created by various organisms as secondary metabolites and the organisms with these cytotoxic chemical weapons can siuvive in the biochemical warfare over billion years. The organisms we observe today are the survival of the fittest, and natural products isolated from these organisms can have such a diverse biological activity, especially excellent cytotoxicity that is the reason why most of anticancer agents and antibiotics have originated from natural products. However, natural products were not as effective as in other therapeutic areas such as type 2 diabetes, depression, osteoporosis  

Solid-Phase Organic Synthesis Concepts, Strategies, and Applications, First Edition. Edited by Patrick H. Toy and Yulin Lam. 

2 DIVERGENT SYNTHESIS OF NATURAL PRODUCT-LIKE POLYHETEROCYCLES USING A CYCLIC IMINIUM AS A SINGLE KEY INTERMEDIATE 

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