Automated synthesis strategies

This strategy using rapid automated synthesis of libraries of peptides and fluorescent screening of reactivity has allowed Miller to identify specific peptide-catalysts for specific applications such as the KR of an intermediate en route to an aziridomi-tosane [165,169], the KR of certain fert-alcohols [166], the regioselective acylation of carbohydrates [168], and finally the KR of AT-acylated fert-amino alcohols with s values from 19 to >50 (Scheme 21) [166],... 

Solution-phase combinatorial synthesis provides a homogeneous reaction medium and overcomes the drawbacks of a solid-phase strategy. An easy and reliable purification method is required in solution-phase combinatorial (parallel) synthesis to facihtate automation. The throughput in solution-phase automated synthesis is directly related to the facility of performing a purification process (work-up), compound separation, etc.15... 

IV. Design of an Automated Solid-Phase Oligosaccharide Synthesis Strategy. 43... 

For the automated synthesis of CS hexasaccharides, Peter Seeberger s group designed a photolabile nitrobenzyl ether-based linker to the Merrifield resin (Scheme 10.15) [31]. Their advanced strategy also differs by the use of monosaccharide donors for the... 

In the parallel synthesis strategy (Figure 3a), all 27 compounds are synthesized in parallel in separate reaction vessels, and this is not any different from traditional organic chemistry synthesis of compounds one at a time, except that in most cases synthesis is automated. This strategy requires performing 27 x 3 = 81 reaction steps in order to obtain 27 compounds. Compounds are synthesized either by solution-phase or solid-phase chemistry in relatively large quan-... 

The most important strategy for the linear synthesis of oligonucleotides has been developed by M. Caruthers. Nowadays, the phosphite triester method is widely used in the automated synthesis of oligonucleotides on silica. The principle is shown in Scheme 25.1. 

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