Diversity-oriented synthesis synthetic strategy

Figure 6.28 Some different scaffolds prepared through diversity oriented synthesis (DOS). (Taylor, S. J. et al. Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates. Angew. Chem. Int. Ed. Engl. 2004, 43, 1681-1685.) ...

Figure 4.1. Planning strategies and end goals involved in target-oriented synthesis, focused library synthesis (combinatorial synthesis), and diversity-oriented synthesis. The first two approaches use retrosynthetic analysis to design the synthesis of target compounds. Diversity-oriented synthesis uses forward synthetic analysis to produce libraries that occupy diffuse regions of chemical space.

Schreiber and coworkers recently described a synthetic strategy using o elements, functionality that encodes skeletal information that can be transformed into products with different skeletons. The diversity-oriented synthetic approach, aimed at understanding the function of proteins has taken root in a number of laboratories around the world. DOS develops on what combinatorial chemistry initially sought to achieve. As previously indicated, DOS as a combinatorial approach to parallel synthesis expands the array diversity by increasing the number of stereoisomers per array and varying the number of core scaffolds per array. 

---