Diversity-oriented synthesis design strategies

Figure 4.1. Planning strategies and end goals involved in target-oriented synthesis, focused library synthesis (combinatorial synthesis), and diversity-oriented synthesis. The first two approaches use retrosynthetic analysis to design the synthesis of target compounds. Diversity-oriented synthesis uses forward synthetic analysis to produce libraries that occupy diffuse regions of chemical space.

The efficiency of total synthesis should then benefit to the growing research efforts in chemical biology and drug discovery in the future, in connection with recently designed strategies like diversity-oriented synthesis (DOS) and function-oriented synthesis (FOS). 

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