Catalysis high throughput

Zech, T, Schunk, S., Klein, J., Demuth, D., The integrated materials chip for high-throughput experimentation in catalysis research, in Proceedings of the 6th International Conference on Microreaction Technology, IMRET 6, pp. 32-36 (11-14 March 2002), AIChE Pub. No. 164, New Orleans. 

Corma A, Serra JM, SemaP, MolinerM. 2005. Integrating the high-throughput characterization into combinatorial heterogeneous catalysis unsupervised constmction of quantitative stracture/property relationship models. J Catal 232 335-341. 

High throughput screening is one of the hot topics in heterogeneous catalysis. Advanced experimental techniques have been developed to screen and develop solid catalysts for gas-phase systems. However, for catalytic three-phase systems, rapid screening has got much less attention [1-6]. Three-phase catalysis is applied in numerous industrial processes, from synthesis of fine chemicals to refining of crade oil. 

A. Hagemeyer, P. Strasser and A. F. Volpe, Jr, (Eds), High-throughput screening in chemical catalysis (Wiley-VCH, Weinheim, 2004). 

Kubanek, P., Busch, O., Thomson, S. et al. (2004) Imaging reflection IR spectroscopy as a tool to achieve higher integration for high-throughput experimentation in catalysis research. J. Comb. Chem., 6, 420. 

Johann, T., Brenner, A., Schwickardi, M. et al. (2003) Listening to catalysis - a real time parallel method for high throughput product analysis. Catal. Today, 81, 449. 

The best combination turned out to be L5 /A9 (ee = 90% at room temperature and 99% at —78 °C with benzaldehydes and ee = 92-99% with other aldehydes).87 Further improvements were reported later.89 Although only a few dozen reactions were monitored by a JASCO-CD-995 instrument, the CD-based assay is amenable to high-throughput screening of enantioselective catalysts. The chemistry itself lends itself ideally to combinatorial asymmetric metal catalysis, since the principle of asymmetric activation is turning out to be very powerful.89... 

Most of the techniques discussed above are typically used ex situ for catalyst characterization before and after reaction. This is normally the easiest way to carry out the experiments, and is often sufficient to acquire the required information. However, it is known that the reaction environment plays an important role in determining the structure and properties of working catalysts. Consequently, it is desirable to also try to perform catalytic studies under realistic conditions, either in situ [113,114,157, 191-193] or in the so-called operando mode, with simultaneous kinetics measurements [194-196], In addition, advances in high-throughput (also known as combinatorial) catalysis call for the fast and simultaneous analysis of a large number of catalytic samples [197,198], This represents a new direction for further research. 

J.C. Vedrine, E.G. Derouane, in Combinatorial Catalysis and High Throughput Catalyst Design and Testing, E.G. Derouane, F. Lemos, A. Corma, F.R. Ribeiro (Eds.), Kluwer Academic Publishers, 2000, p. 125. 

High-Throughput Experimentation and Combinatorial Approaches in Catalysis... 

HIGH-THROUGHPUT EXPERIMENTATION AND COMBINATORIAL CATALYSIS — DEFINITION AND SCOPE... 

Table 11.3 Differences in the High-Throughput Experimentation for Molecular Entities and Inorganic Solids Applied for Catalysis...

Refinery Catalysis Applications in High-Throughput Experimentation... 

---