Novel Strategies in Aldolase-catalyzed Synthesis of Iminosugars

Novel Strategies in Aldolase-catalyzed Synthesis of Iminosugars 

In this sense, enzymatic catalysis is especially attractive for syntheses demanding highly regio- and stereoselectivity. Particularly dihydroxyacetone phosphate (DHAP) dependent aldolases are among the most suitable biocatalyst for imino-sugar synthesis due to their high stereoselectivity and chiral induction capacity [10, 12, 13]. The aldol addition of DHAP (1) to a synthetic equivalent of an 

Modem Biocaudys Stereoselective and Environmentady Friendly Reactions. Edited by Wolf-Dieter Fessner and Thorleif Anfhonsen Copyright 2009 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 978-3-527-320714 

Here we account on our research about a novel chemo-enzymatic approach to the synthesis of iminosugars from N-protected-aminoaldehydes as donor substrates and aldolases as biocatalysts for the key aldol addihon reaction. 

DHAP-Aldolase-mediated Synthesis of Iminosugars from N-Cbz-amino Aldehydes 

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I 19 Novel Strategies in Aldolase-catalyzed Synthesis of Iminosugars O OH O... 

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