Nuclear factor-kappaB

Hoffmann A, Baltimore D (2006). Circuitry of nuclear factor kappaB signaling. Immunol Rev 210 171-186. 

Kraus J, Bomer C, Giannini E, HoUt V (2003) The role of nuclear factor kappaB in tumor necrosis factor-regulated transcription of the human mu-opioid receptor gene. Mol Pharmacol 64 876-884 Law PY, Loh HH, Wei LN (2004) Insights into the receptor transcription and signaling implications in opioid tolerance and dependence. [Review] [123 refs]. Neuropharmacology 47(Suppl 1) 300-311... 

Wetzel MA, Steele AD, Eisenstein TK, Adler MW, Henderson EE, Rogers TJ (2000) Mu-opioid induction of monocyte chemoattractant protein-1, RANTES, and IFN-gamma-inducible protein-10 expression in human peripheral blood mononuclear cells. J Immunol 165 6519-6524 Widmer U, Manogue KR, Cerami A, Sherry B (1993) Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines. J Immunol 150 4996-5012 Ye RD (2001) Regulation of nuclear factor kappaB activation by G-protein-coupled receptors. [Review] [136 refs]. J Leukoc Biol 70 839-848... 

Kraus J, Bomer C, Giannini E, HoUt V (2003) The role of nuclear factor kappaB in tumor necrosis factor-regulated transcription of the human mu-opioid receptor gene. Mol Pharmacol 64 876-884... 

Han HS, Karabiyikoglu M, Kelly S, Sobel RA, Yenari MA. Mild hypothermia inhibits nuclear factor-kappab translocation in experimental stroke. J Cereb Blood Flow Metab 2003 23 589-598. 

Han JH, Choi SJ, Kurihara N, Koide M, Oba Y, Roodman GD. Macrophage inflammatory protein-lalpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand. Blood 2001 97(11) 3349—3353. 

Kim, G.Y., Kim, J.H., Ahn, S.C. et al. 2004. Lycopene suppresses the lipopolysaccharide-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor-kappaB. Immunology 113 203-211. 

Wang SY, Feng R, Lu Y, Bowman L and Ding M. 2005. Inhibitory effect on activator protein-1, nuclear factor-kappab, and cell transformation by extracts of strawberries (fragaria X ananassa duch.). J Agric... 

Hofbauer LC, Heufelder AE (2000) Clinical review 114 hot topic. The role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in the pathogenesis and treatment of metabolic bone diseases. J Clin Endocrinol Metab 85 2355-2363... 

Cheung J, Mak YT, Papaioannou S, Evans BA, Fogelman I, Hampson G (2003) Interleukin-6 (IL-6), IL-1, receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin production by human osteoblastic cells comparison of the effects of 17-beta oestradiol and raloxifene. J Endocrinol 177 423-433... 

Takami M, Takahashi N, Udagawa N, Miyaura C, Suda K, Woo JT, Martin TJ, Nagai K, Suda T (2000) Intracellular calcium and protein kinase C mediate expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in osteoblasts. Endocrinology 141 4711 -4719... 

Lin, Y.L. and Lin, J.K., (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB, Mol Pharmacol, 52, 465, 1997. 

Haeberle, H.A., et al., Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways, J. Infect. Dis. 186, 9, 1199, 2002. 

Caspar-Bauguil, S., Tkaczuk, J., Haure, M.J., Durand, M., Alcouffe, J., Thomsen, M., Salvayre, R., and Benoist, H., 1999, Mildly oxidized low-density lipoproteins decrease early production ofinterleukin 2 and nuclear factor kappaB binding to DNA in activated T-lymphocytes, Biocfem. J. 337 269-274. 

Li, D., Saldeen, T., Mehta, J.L., 1999, gamma-tocopherol decreases ox-LDL-mediated activation of nuclear factor-kappaB and apoptosis in human coronary artery endothelial cells. Biochem. Biophys. Res. Commun. 259 157-161. 

Ohlsson, B.C., Englund, M.C., Karlsson, A.L., Knutsen, E., Erixon, C, Skribeck, H., Liu, Y., Bondjers, G., and Wiklund, O., 1996, Oxidized low density lipoprotein inhibits hpopolysaccharide-induced binding of nuclear factor-kappaB to DNA and the subsequent expression of tumor necrosis factor-alpha and interleukin-1 beta in macrophages, J. Clin. Invest. 98 78-89. 

Gamard, C.J.L., Dbaibo, G.S., Liu, B., Obeid, L.M. and Hannun, Y.A., 1997, Selective involvement of ceramide in cytoMne-induced apoptosis. Ceramide irrhibits phorbol ester activation of nuclear factor kappaB. J. Biol Chem., 272 16474-16481. 

C. Van Waes, Nuclear factor-kappaB in development, prevention, and therapy of cancer, Clin. Cancer Res., 2007, 13(4), 1076. 

H.A. Haeberle, F. Nesti, H.J. Dieterich, Z. Gatalica, R.P. Garofalo, Perflubron reduces lung inflammation in respiratory syncytial virus infection by inhibiting chemokine expression and nuclear factor-kappaB activation, Am. J. Respir. Crit. Care Med. 165 (2002) 1433-1438. 

Afaq F, Adhami VM, Ahmad N, Mukhtar H. 2003a. Inhibition of ultraviolet B-mediated activation of nuclear factor kappaB in normal human epidermal keratino-cytes by green tea constituent (—)-epigallocatechin-3-gallate. Oncogene 22 1035-1044. 

C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol 557 221-229. 

Sun C, Hu Y, Liu X, Wu T, Wang Y, He W, Wei W. 2006. Resveratrol downregulates the constitutional activation of nuclear factor-kappaB in multiple myeloma cells, leading to suppression of proliferation and invasion, arrest of cell cycle, and induction of apoptosis. Cancer Genet Cytogenet 165 9-19. 

Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE, Price JE. 2005. Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res 11 7490-7498. 

Bhattacharyya S, Mandal D, Sen GS, Pal S, Banerjee S, Lahiry L, Finke JH, Tannenbaum CS, Das T, Sa G. 2007. Tumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death Protection by curcumin. Cancer Res 67 362-370. 

Fernandez-Martinez AB, Collado B, Bajo AM, Sanchez-Chapado M, Prieto JC, Carmena MJ. 2007. Vasoactive intestinal peptide induces cyclooxygenase-2 expression through nuclear factor-kappaB in human prostate cell lines Differential time-dependent responses in cancer progression. Mol Cell Endocrinol 270 8-16. 

Kamat AM, Sethi G, Aggarwal BB. 2007. Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells. Mol Cancer Ther 6 1022-1030. 

Khanbolooki S, Nawrocki ST, Arumugam T, Andtbacka R, Pino MS, Kurzrock R, Logsdon CD, Abbruzzese JL, McConkey DJ. 2006. Nuclear factor-kappaB maintains TRAIL resistance in human pancreatic cancer cells. Mol Cancer Ther 5 2251— 2260. 

Li L, Aggarwal BB, Shishodia S, Abbruzzese J, Kurzrock R. 2004. Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer 101 2351-2362. 

Lin YG, Kunnumakkara AB, Nair A, Merritt WM, Han LY, Armaiz-Pena GN, Kamat AA, Spannuth WA, Gershenson DM, Lutgendorf SK, Aggarwal BB, Sood AK. 2007. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway. Clin Cancer Res 13 3423-3430. 

Siwak DR, Shishodia S, Aggarwal BB, Kurzrock R. 2005. Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer 104 879-890. 

Thomas RK, Sos ML, Zander T, Mani O, Popov A, Berenbrinker D, Smola-Hess S, Schultze JL, Wolf J. 2005. Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. Clin Cancer Res 11 8186-8194. 

Andreadi CK, Howells LM, Atherfold PA, Manson MM. 2006. Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols. Mol Pharmacol 69 1033-1040. 

Pan MH, Lin-Shiau SY, Ho CT, Lin JH, Lin JK. 2000. Suppression of lipopolysacchar-ide-induced nuclear factor-kappaB activity by theaflavin-3,3 -digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages. Biochem Pharmacol 59 357-367. 

Levites Y, Youdim MB, Maor G, Mandel S. 2002b. Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures. Biochem Pharmacol 63 21-29. 

NF-icB, Nuclear factor-kappaB GFAP, glial fibrillary acidic protein /3-APP, /3-amyloid precursor protein TGF-/33, transforming growth factor-/33 Cdk4, cyclin-dependent kinase and p53, a tumor-suppressor gene. 

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