Proteins inducible

Interferon alfacon-1 (Inferax ), interferon alfa-2b (IntronA ), and interferon alfa-2a (Roferon -A) are applied in the treatment of chronic hepatitis B and C and some malignancies, especially hairy cell leukemia. IFN-a proteins induce the expression of antiviral, antiproliferative and immunomodulatory genes. 

Walkup, L.K. Kogoma, T. (1989). E. coli proteins inducible by oxidative stress mediated by the superoxide radical. J. Bacteriol. 171, 1476-1484. 

It is becoming clear that the MgATP hydrolysis is not required to induce protein-protein electron transfer, but its role in nitrogenase function is still undefined. The most likely hypothesis at the moment is that its hydrolysis, on the Fe protein, induces important changes in the MoFe protein, presumably by altering the conformation of the enzyme complex. Nevertheless, the nature of the changes in the MoFe protein remain obscure. 

King, G.J. Hussey, C.E., Jr Turner, V.A. (1986). A protein induced by NaCl in suspension cultures of Nicotiana tabacum accumulates in whole plant roots. Plant Molecular Biology, 7, 441-9. 

HIV-infected glia secrete inflammatory factors that can indirectly contribute to excitotoxicity (Giulian et al. 1996). The HIV envelope protein induces the secretion... 

Koka P, He K, Zack JA, Kitchen S, Peacock W, Fried 1, Tran T, Yashar SS, MerrUl JE (1995) Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor alpha, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain. J Exp Med 182 941-951... 

Kaplan, H.J. Diamond, J.G. and Brown, S.A. (1979). Vitrectomy in experimental uveitis, II. Method in eyes with protein-induced uveitis. Arch. Ophthalmol. 97, 336-339. 

Weissman D, Rabin RL, Arthos J, et al. Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature 1997 389(6654) 981-985. 

Huang L, Bosch I, Hofmann W, Sodroski J, Pardee AB. Tat protein induces human immunodeficiency vims type 1 (HIV-1) coreceptors and promotes infection with both macrophage-tropic and T-lymphotropic HIV-1 strains. J Virol 1998 72(ll) 8952-8960. 

Ikeda H, Yamaguchi M, Sugai S, Aze Y, Narumiya S, Kakizuka A. Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo. Nat Genet 1996 13 196-202. 

The detection of metal-binding proteins, especially of Cd- and Hg-binding metallothioneins or of the merR protein, induced numerous studies of model compounds of Cd and Hg with more or less simple sulfur- and selenium-containing ligands. 

In the future, this test may be replaced by the proteins induced by vitamin K antagonists absence (PIVKA) concentrations in serum. PIVKAs are coagulation factor precursors, normally not detectable in blood but released into the... 

Engineering of a monomeric green-to-red photoactivatable fluorescent protein induced by blue light. Nat. Biotechnol. 24, 461-5. 

Ataman-Onal Y, Munier S, Ganee A et al (2006) Surfactant-free anionic PLA nanoparticles coated with HIV-1 p24 protein induced enhanced cellular and humoral immune responses in various animal models. J Control Release 112 175-185... 

Efremova NV, Sheth SR, Leckband DE (2001) Protein-induced changes in poly(ethylene glycol) brushes molecular weight and temperature dependence. Langmuir 17 7628-7636... 

Calcium couples muscle membrane excitation to filament contraction. Important work has focused on the proteins present in the T-tubule/SR junction. One protein, an integral component of the T-tubular membrane, is a form of L-type, dihydropyridine-sensitive, voltage-dependent calcium channel. Another, the ryanodine receptor (RyR), is a large protein associated with the SR membrane in the triad that may couple the conformational changes in the Ca2+ channel protein induced by T-tubular depolarization to the Ca2+ release from the SR (Fig. 43-6). 

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