Cancer progression

Koivunen J, Aaltonen V, Peltonen J (2006) Protein kinase C (PKC) family in cancer progression. Cancer Letts 235 1-10... 

In concordance with the central role of ubiquitin modification in multiple cellular functions perturbations of this system are associated with a variety of diseases. Defects in the control of cell cycle regulators by the ubiquitin proteasome system are connected to cancer progression and many E3 ligases were originally identified as oncogenes. 

Cancer is a major cause of premature death in modern society. In vitro and animal research indicates that tea, mainly green tea, may be effective against a wide variety of cancers. Activity has been observed in vitro at all three levels of cancer progression, namely initiation, promotion and transformation (Mitscher et al, 1997). 

Androgen independence is a common feature of prostate cancer progression. CXCR1 expression and the emergence of androgen independence were examined in prostate cancer specimens from patients undergoing hormonal treatment... 

Tomlins, S A, MA Rubin, and AM Chinnaiyan. 2006. Integrative biology of prostate cancer progression. Annu Rev Pathol Mech Dis 1 243-271. 

Bartkova, J., Lukas, J. and Bartek, J. (1997) Aberrations of the Gl- and Gl/ S-regulating genes in human cancer. Progress in Cell Cycle Research 3, 211-220. 

Sgroi DC et al. In vivo gene expression profile analysis of human breast cancer progression. Cancer Res 1999 59 5656-5661. 

Patel V, Hood BL, Mohnolo AA, et al. Proteomic analysis of laser-captured paraffin-embedded tissues a molecular portrait of head and neck cancer progression. Clin. Cancer Res. 2008 14 1002-1014. 

Howell A, Robertson JF, Quaresma AJ, Aschermannova A, Mauriac L, Kleeberg UR, Vergote I, Erikstein B, Webster A, Morris C (2002) Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J Clin Oncol 20 3396-3403... 

Osborne CK, Pippen J, Jones SE, Parker LM, Ellis M, Come S, Gertler SZ, May JT, Burton G, Dimery I, et al. (2002) Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy results of a North American trial. J Clin Oncol 20 3386-3395... 

Gotzmann J, Fischer AN, Zojer M, Mikula M, Proell V, Huber H et al (2006). A crucial function of PDGF in TGF-beta-mediated cancer progression of hepatocytes. Oncogene 25 3170-3185. 

Micromolar quantities of RNS are generated primarily by nitric oxide synthase 2 (NOS2), an enzyme that is up-regulated during colon-cancer progression. As discussed below, deoxycholate (DOC), a hydrophobic secondary bile acid, activates the redox-sensitive transcription factor NF-kB, resulting in increased levels of NOS2 and enhanced S-nitrosylation of proteins. Additional sources of bile-acid-induced ROS and RNS are also likely. ... 

Table 3.6 Observations indicating that development of apoptosis resistance often occurs early in cancer progression in the GI tract.

C. E. Glycoprotein glycosylation and cancer progression. Biochim Biophys Acta 1999, 1473, 21-34. 

Thomas ES, Gomez HL, Li RK, Chung H-C, Fein LE, Chan VF, Jassem J, Pivot XB, KJimovsky JV, de Mendoza FH, Xu B, Campone M, Lerzo GL, Peck RA, Mukhopadhyay P, Vahdat FT, Roche HH. (2007). Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment. J Clin Oncol 25 5210-5217. 

Yesner, R., and D. D. Van Hoff (1978). Pathologic diagnosis of lung cancer reappraisal and prospects. In Muggia, and M. Rozensweig, eds. Lung Cancer Progress in Therapeutics. Raven Press, New York. 

Paweletz CP, Liotta LA, Petricorn EE (2001) New technologies for biomarker analysis of prostate cancer progression laser capture microdissection and tissue proteomics. Urology 57 160-163... 

Holliday DL, Broiulette KT, Markert A et al (2009) Novel multicellular organotypic models of normal and malignant breast tools for dissecting the role of the microenvironment in breast cancer progression. Breast Cancer Res 11 R3... 

SM Smorenburg, CJ Van Noorden. The complex effects of heparins on cancer progression and metastasis in experimental studies. Pharmacol Rev 53 93—105, 2001. 

Abba MC, Drake JA, Hawkins KA, Hu Y, Sun H, Notcovich C, Gaddis S, Sahin A, Baggerly K, Aldaz CM (2004) Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression. Breast Cancer Res 6 R499-R513... 

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