Nuclear factor kappaB regulation

Kamat AM, Sethi G, Aggarwal BB. 2007. Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells. Mol Cancer Ther 6 1022-1030. [Pg.390]

Pandey MK, Sung B, Kunnumakkaia AB, Sethi G, Chaturvedi MM, Aggarwal BB (2008) Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis. Cancer Res... [Pg.4499]

Bhardwaj, A, Sethi, G., Vadhan-Raj, S., Bueso-Ramos, C., Takada, Y., etal 2007. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood, 709 2293-2302. [Pg.514]

Kraus J, Bomer C, Giannini E, HoUt V (2003) The role of nuclear factor kappaB in tumor necrosis factor-regulated transcription of the human mu-opioid receptor gene. Mol Pharmacol 64 876-884 Law PY, Loh HH, Wei LN (2004) Insights into the receptor transcription and signaling implications in opioid tolerance and dependence. [Review] [123 refs]. Neuropharmacology 47(Suppl 1) 300-311... [Pg.334]

Wetzel MA, Steele AD, Eisenstein TK, Adler MW, Henderson EE, Rogers TJ (2000) Mu-opioid induction of monocyte chemoattractant protein-1, RANTES, and IFN-gamma-inducible protein-10 expression in human peripheral blood mononuclear cells. J Immunol 165 6519-6524 Widmer U, Manogue KR, Cerami A, Sherry B (1993) Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines. J Immunol 150 4996-5012 Ye RD (2001) Regulation of nuclear factor kappaB activation by G-protein-coupled receptors. [Review] [136 refs]. J Leukoc Biol 70 839-848... [Pg.336]

Kraus J, Bomer C, Giannini E, HoUt V (2003) The role of nuclear factor kappaB in tumor necrosis factor-regulated transcription of the human mu-opioid receptor gene. Mol Pharmacol 64 876-884... [Pg.371]

Lin, Y.L. and Lin, J.K., (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB, Mol Pharmacol, 52, 465, 1997. [Pg.202]

C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol 557 221-229. [Pg.210]

Li L, Aggarwal BB, Shishodia S, Abbruzzese J, Kurzrock R. 2004. Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer 101 2351-2362. [Pg.392]

Siwak DR, Shishodia S, Aggarwal BB, Kurzrock R. 2005. Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer 104 879-890. [Pg.396]

Pan MH, Lin-Shiau SY, Ho CT, Lin JH, Lin JK. 2000. Suppression of lipopolysacchar-ide-induced nuclear factor-kappaB activity by theaflavin-3,3 -digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages. Biochem Pharmacol 59 357-367. [Pg.449]

Kubota T, Kushikata T, Fang J, Krueger JM. Nuclear factor-kappaB inhibitor peptide inhibits spontaneous and interleukin-1 beta-induced sleep. Am J Physiol Regul Integr Comp Physiol 2000 279 R404-R413. [Pg.530]

Madrigal JL, Moro MA, Lizasoain I, Lorenzo P, Castrillo A et td (2001) Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor kappaB-mediated mechanisms. J Neurochem 76 532-538... [Pg.314]

Since an extreme pro-oxidant status of a cell can lead to a progressive loss of cellular function and eventual death, cells have developed mechanisms to detect changes in the redox status of cells. These switches are used to regulate and turn on the antioxidant machinery of the cell. These signals are largely mediated by redox-sensitive transcription factors. Although a large number of very extensively studied transcription factors are now know to respond to redox status, nuclear factor-kappaB (NF-kB) deserves special mention. NF-kB usually resides in the... [Pg.1907]

S. Hoshi, M. Goto, N. Koyama, K. Nomoto, and H. Tanaka, Regulation of vascular smooth muscle cell proliferation by nuclear factor-kappaB and its inhibitor, I-kappaB, J Biol Chem 275, 883-889 (2000). [Pg.161]

Kang, JS., Yoon, Y.D., Han, M.H., Han, S.B., Lee, K., Lee, K.H., Park, S.K., and Kim, H.M., Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway implications of AkT., extracellular signal-regulated kinasE., and nuclear factor-kappaB/Rel signaling pathways. Mol Pharmacol, 69 (2006) 941-949. [Pg.515]

Chen, F., Castranova, V., and Shi, X., New insights into the role of nuclear factor-kappaB in cell growth regulation, Am. J. Pathol, 159, 387-397, 2001. [Pg.68]

Kang, J.L., Lee, K., and Castranova, V., Nitric oxide up-regulates DNA-binding activity of nuclear factor-kappaB in macrophages stimulated with silica and inflammatory stimulants. Mol Cell. Biochem., 215,1-9,2000. [Pg.70]

Chen CC, Chow MP, Huang WC, Lin YC, Chang YJ (2004a) Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (lCAM-1) in respiratory epithehal cells through activator protein-1 and nuclear factor-kappaB structure-activity relationships. Mol Pharmacol... [Pg.104]

Bava SV, Puliappadamba VT, Deepti A, Nair A, Karunagaran D, Ante RJ (2005) Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization. J Biol Chem 280 6301-6308... [Pg.2235]

Anand P, Kunnumakkara AB, Harikumar KB, Ahn KS, Badmaev V, Aggarwal BB (2008) Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiales apoptosis. Cancer Res 68 8861-8870... [Pg.3065]

Sun, C., Hu, Y., Liu, X., Wu, T., Wang, Y., He, W., and Wei, W. 2006. Resveratrol down-regulates the constitutional activation of nuclear factor-kappaB in multiple myeloma cells, leading to suppression of proliferation and invasion, arrest of cell cycle, and induction of apoptosis. Cancer Genet Cytogenet, 765 9-19. [Pg.522]

Bernier, R, Barbeau, B, Tremblay, MJ and Olivier, M (1998) The lipophosphoglycan of Leishmania donovani up-regulates HIV-1 transcription in T cells through the nuclear factor-kappaB elements. J Immunol 160 2881-2888. [Pg.1984]

Nunokawa, Y., Oikawa, S., and Tanaka, S. (1996). Human inducible nitric oxide synthase gene is transcriptionally regulated by nuclear factor-kappaB dependent mechanism. Biochem. Biophys. Res. Commun. 223, 347-352. [Pg.184]

Briassouli, R, Chan, R, Savage, K., Reis-Filho, J.S., and Linardopoulos, S. (2007). Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha. Cancer Res. 67, 1689-1695. [Pg.323]

Stehlik C, deMartin R, Kumabashiri I, Schmid JA, Binder BR, Lipp J. Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J Exp Med 1998 188 211-216. [Pg.153]

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