Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Mouse micronucleus

Physicochemical properties requked include melting/boiling point, vapor pressure, solubiUty, and flammabiUty/explosion characteristics. The toxicological studies include acute toxicity tests, oral, inhalation, and dermal skin and eye kritation skin sensiti2ation subacute toxicity, oral, inhalation, and dermal and mutagenicity tests. In vitro reverse mutation assay (Ames test) on Salmonella typhimurium and/or E.scherichia coli and mammalian cytogenic test. In vivo mouse micronucleus test. [Pg.301]

In vitro metaphase analysis (or mouse micronucleus test)... [Pg.321]

Toxicological properties Acute toxicity (by two routes of admission) Skin irritation Eye irritation Skin sensitization 28 days subacute toxicity Ames test In vitro metaphase analysis (or mouse micronucleus test)... [Pg.328]

The mouse micronucleus test (which detects chromosome breakage or chromosome loss from mitotic abnormalities in bone marrow erythrocytes) (MacGregor et al. 1979). [Pg.1011]

Benzyl chloride caused genetic mutations and chromosome-damaging effects in a wide variety of in vitro assays it was not mutagenic in vivo in the mouse micronucleus assay. ... [Pg.81]

MEKP was not mutagenic in bacterial assays, but it did induce sister chromatid exchanges and chromosomal aberrations in Chinese hamster ovary cells it was also negative in the in vivo mouse micronucleus assay. ... [Pg.479]

TETA was mutagenic in bacterial assays and was positive in sister chromatid exchanges and unscheduled DNA synthesis tests in vitro It was not clastogenic in the mouse micronucleus test in vivo after oral or intraperitoneal administration. [Pg.709]

Mutagenesis Human peripheral blood lymphocytes were exposed to zalcitabine, and at 1.5 mcg/mL or more, dose-related increases in chromosomal aberrations were seen. Oral doses of zalcitabine at 2500 and 4500 mg/kg were clastogenic in the mouse micronucleus assay. [Pg.1864]

In mammalian assays, glycidol has been tested in human lymphocytes and Chinese hamster cells in vitro for induction of chromosomal aberrations and sister chromatid exchanges. It was also tested in vivo in the mouse micronucleus assay. All test results were positive, as were those of gene mutation assays using Chinese hamster V79 cells and mouse lymphoma L5178Y cells. An in-vivo assay to detect chromosomal aberrations in mouse bone-marrow cells gave negative results. [Pg.478]

Sheldon, T. (1989b) An evaluation of caprolactam and benzoin in the mouse micronucleus test. Mutat. Res., 224, 351-355... [Pg.399]

Adler, I.-D., Kliesch, U., van Hiunmelen, P. Kirsch-Volders. M. (1991) Mouse micronucleus tests with known and suspect spindle poisons results from two laboratories. Mutagenesis, 6,47-53... [Pg.711]

A mixture of cis- and Zra .s-l,3-dichloropropcnc has given contradictory results in the mouse micronucleus assay. In the most recent study, it was positive in female (but not in male) NMRI mice. On the other hand, it did not induce mieronuclei in the bone marrow, spleen or liver of partially hepatectomized rats, nor did it cause unscheduled DNA synthesis in rat hepatocytes in vivo. [Pg.942]

Cytogenetic damage Mouse Micronucleus test Chromosomal fragments in erythrocyte stem cells <1 mo M M M M... [Pg.83]

In vivo genotoxicity studies or clastogenicity studies are not mentioned in the EMEA guidance, and PS ODNs have been routinely tested in the mouse micronucleus assay. Again, even when exposure to the bone marrow is well documented, the assays are routinely negative. Other assays like unscheduled... [Pg.549]

Isis Compound Number Salmonella E. coli Cytogenetics (Chromosomal Aberation) Mouse Lymphoma Mammalian Mutagenesis CHO/HGPRT Mammalian Mutagenesis Rat Hepatocyte UDS Mouse Micronucleus... [Pg.550]

Genetic toxicity Ames/ in vitro chromosomal abberations human lymphocyte (CAHL)/ mouse micronucleus (MM) Toxicity single dose—chimpanzee, rat/ repeat dose— chimpanzee, rat/ mouse2 Fertility mouse2... [Pg.595]

Prenatal and postnatal development none Genetic toxicology0 Ames test, human lymphocyte chromosomal aberration assay, CHO/HGPRT gene mutation assay, mouse micronucleus assay Carcinogenicity none... [Pg.932]

Not genotoxic (Ames, human lymphocyte peripheral blood lymphocyte chromosome aberration test, in vivo mouse micronucleus test)... [Pg.1048]

Fertility and early embryonic development rats Developmental rats, rabbits Prenatal and postnatal development rats Genetic toxicology in vitro bacterial and CFIO cell assays, mouse micronucleus assay Carcinogenicity proliferation in vitro and in vivo Tissue cross-reactivity human tissues Other safety studies in a variety of species Single dose none... [Pg.1056]

Developmental cynomolgus monkeys Prenatal and postnatal development cynomolgus monkeys Genetic toxicology Ames test, chromosome aberration assay in human peripheral lymphocytes, in vivo mouse micronucleus Carcinogenicity none... [Pg.1061]

Genetic toxicology Ames test, in vivo mouse micronucleus... [Pg.1061]

Developmental rhesus monkeys Prenatal and postnatal development none Genetic toxicology Ames test, chromosomal aberrations in human lymphocyte assay, mouse micronucleus test Carcinogenicity none Single dose none Repeat dose rats... [Pg.1068]

Genetic toxicology Ames, mouse micronucleus, human lymphocyte... [Pg.1070]

Meshram, G.P., Rao, K.M. (1988). Cytogenetic activity of methyl isocyanate in vivo in the mouse micronucleus test. Toxicol. Lett. 42 65-71. [Pg.310]

Propofol Tests for mutagenicity included the Ames mutation test, gene mutation/gene conversion using Saccharomyces cerevisiae, in vitro cytogenetic studies in Chinese hamsters, and a mouse micronucleus test. None of these have shown mutagenic potential. [Pg.133]

No evidence of genotoxicity was observed in vitro with or without metabolic activation in the following assays microbial mutagen tests using mutant strains of Salmonella typhimurium or Escherichia coli, Chinese hamster ovary forward mutation assay, unscheduled DNA synthesis in rat primary hepatocytes, chromosome aberrations in Chinese hamster ovary cells, and spindle inhibition in human lymphocytes. In addition, there was no evidence of genotoxicity in vivo in a mouse micronucleus test there was equivocal evidence of mutagenicity in a mouse domi nant lethal test. [Pg.219]

Mutagenic in bacterial mutation assay (Ames), in vitro cytogenetics assay, and mouse micronucleus test. [Pg.537]

See other pages where Mouse micronucleus is mentioned: [Pg.486]    [Pg.55]    [Pg.69]    [Pg.93]    [Pg.94]    [Pg.519]    [Pg.635]    [Pg.240]    [Pg.549]    [Pg.554]    [Pg.662]    [Pg.946]    [Pg.965]    [Pg.1062]    [Pg.32]    [Pg.1661]    [Pg.107]    [Pg.136]    [Pg.501]   
See also in sourсe #XX -- [ Pg.558 ]



SEARCH



Micronucleus

Mouse bone marrow micronucleus test

Mouse micronucleus test

© 2024 chempedia.info