Monkey cynomolgus

Osborn BL, Olsen HS, NardeUi B, Murray JH, Zhou JX, Garcia A, Moody G, Zaritskaya LS, Sung C (2002) Pharmacokinetic and pharmacodynamic studies of a human serum albumin-interferon-alpha fusion protein in cynomolgus monkeys. J Pharmacol Exp Ther 303 540-548 Ozes ON, Reiter Z, Klein S, Blatt LM, Taylor MW (1992) A comparison of interferon-Conl with natural recombinant interferons-alpha antiviral, antiproliferative, and natural kiUer-inducing activities. J Interferon Res 12 55-59... 

In a second more extensive study, Capronor was implanted in rats and cynomolgus monkeys. Clinical chemistry observations, physical examinations, qualitative food consumption, urinalysis, and oph-... 

WAGNER J D, CEFALU W T, ANTHONY M S, LITWAK K N, ZHANG L and CLARKSON T B (1997) Dietary soy protein and estrogen replacement therapy improve cardiovascular risk factors and decrease aortic cholesteryl ester content in ovariectomized cynomolgus monkeys. ... 

Kosofsky, B.E. Molliver, M.E. Morrison, J.H. and Foote, S.L. The serotonin and norepinephrine innervation of primary visual cortex in the Cynomolgus monkey (Macaca fascicularis). J Comp Neurol 230 168-178, 1984. 

Foster WG. 1992. Reproductive toxicity of chronic lead exposure in the female Cynomolgus monkey. Rep Toxicol 6 123-131. 

Foster WG, McMahon A, Rice DC. 1996. Sperm chromatin structure is altered in cynomolgus monkeys with environmentally relevant blood lead levels. Toxicol Ind Health 12(5) 723-735. 

Foster WG, Singh A, McMahon A, et al. 1998. Chronic lead exposure effects in the cynomolgus monkey (macaca fascicularis) testis. Ultrastruct Pathol 22(1) 63-71. 

Goralczyk, R., S. Buser, J. Bausch, W. Bee, U. Zuhlke, and F.M. Barker. 1997. Occurrence of birefringent retinal inclusions in cynomolgus monkeys after high doses of canthaxanthin. Invest. Ophthalmol. Vis. Sci. 38 741-752. 

Phase I and Phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey and cynomolgus monkey, Drug Metab. Dispos. 1995, 23, 1231-1241. 

With so many other toxicants present in fire smoke there must be some which reduce the toxicity of HCN. Similar findings were also found for cynomolgus monkeys exposed to smoke containing HCN vs. HCN alone (14). 

Establishing what the lethal level of blood cyanide is for humans is a difficult task. Based on extensive inhalation studies of HCN in mice a level of 1 mg/L of blood was suggested (12). In rats, a level of 2 mg/L of blood was found to be lethal (15). In limited experiments with cynomolgus monkeys, an exposure concentration of 150 ppm for 30 min would result in 3 mg/L of blood cyanide and would be lethal for these primates. Thus we have a range of 1 to 3 mg/L in experimental animals. The lethal level, however, has been found to be somewhat dependent upon exposure concentration and duration of exposure (12). 

Initial safety tests were carried out in beagle dogs and subsequently in cynomolgus monkeys. Single bolus i.v. doses of up to 100 mg kg-1 were used and were found to exert no negative effect upon general condition, blood pressure, heart or cardiovascular parameters, respiration rate or body temperature. No safety tests evaluating potential product effects upon the central nervous system were undertaken, as the protein is considered unlikely to cross the blood-brain barrier. 

Intramuscular injection of 5 mg Pb+2/kg BW daily during pregnancy or lactation Cynomolgus monkey, Macaca fascicularis Abortions and death in pregnant monkeys cerebral pathology in newborns 19... 

Cynomolgus monkey, Macaca 0.75 mg/kg BW Single intravenous (iv) injection produced reduced appetite 7 days postexposure 13... 

Cynomolgus monkey 1.1 mg/kg BW Single iv injection resulted in tremors, hyperactivity, ataxia, stupor, unconsciousness 13... 

Purser, D.A. 1984. A bioassay model for testing the incapacitating effects of exposure to combustion product atmospheres using cynomolgus monkeys. Jour. Fire Sci. 2 20-36. 

Clarkson TB (1994) Estrogens, progestins, and coronary heart disease in cynomolgus monkeys. Fertil Steril 62(Suppl 2) 147S—15IS... 

Wagner JD, Clarkson TB, St Clair RW, Schwenke DC, Shively CA, Adams MR (1991) Estrogen and progesterone replacement therapy reduces low density lipoprotein accumulation in the coronary arteries of surgically postmenopausal cynomolgus monkeys. J Clin Invest 88 1995-2002... 

Hutto D. et al., B cell hyperplasia associated with immunosuppression in cynomolgus monkeys, Vet. Pathol., 40, 624, 2003. 

The mechanism of this effect was addressed in a study in which 2-5 days treatment of female cynomolgus monkeys with relacatib transiently caused a 2-3-fold increase in plasma levels of parathyroid hormone (PTH, a bone anabolic agent) post-dosing compared to vehicle-treated animals [24]. 

During cardiac sensitization tests, cynomolgus monkeys were exposed at 0, 3,000 (one monkey), 5,000 (two monkeys), or 10,000 ppm (two monkeys)... 

Four cynomolgus monkeys (gender not stated) were individually exposed via a face mask to a concentration at 60 ppm for 30 min (Purser 1984). Each animal was exposed on three occasions. The same animals were used for hypoxia and hypercapnia tests. HCN, supplied from a standard gas mixture, was diluted with air the concentration was... 

---