Mouse bone marrow micronucleus test

Kado NY, PA Kuzmicky, G Loarca-Pina, MM Mumtaz (1998) Genotoxicity testing of methyl tertiary-butyl ether (MTBE) in the Salmonella microsuspension assay and mouse bone marrow micronucleus test Mut Res 412 131-138. 

Westmoreland, C. and D.G.Gatehouse. 1991. Effects of aniline hydrochloride in the mouse bone marrow micronucleus test after oral administration. Carcinogenesis 12 1057-1059. 

There were no indications of genotoxic potential for 2,4-D acid, or any of its derivatives, in bacterial assays, in unscheduled DNA synthesis assay, or in mouse bone marrow micronucleus tests. ... 

Propargyl alcohol induced chromosomal aberrations in Chinese hamster ovary (CHO) cells in vitro with and without metabolic activation it was negative in the mouse bone marrow micronucleus test and in the Salmonella lm.zvam.Aiz.vi microsome assay." ... 

TCA was not mutagenic in bacterial assays." Neutralized TCA was not clastogenic in human lymphocytes in vitro or in the mouse bone marrow micronucleus test. ... 

Mackay JM, Fox V, Griffiths K, et al Trichloroacetic acid Investigation into the mechanism of chromosomal damage in the in vitro human lymphocyte cytogenetic assay and the mouse bone marrow micronucleus test. Carcinogenesis 16(5) 1127-1133, 1995... 

The stepwise procedure usually starts with the determination of the LD50, a short term repeated exposure test in rodents and the evaluation of genotoxicity by an in vitro bacterial test system (Ames-test) and for cytogenicity in mammalian cells. In case of indication for genotoxicity the results are verified in vivo usually by the mouse bone marrow micronucleus test. For further evaluation the compound additional tests including studies on toxicokinetics or the toxic mechanisms will follow. Such information provides information on the reactivity of the test compound, its... 

Kevekordes S, Gebel T, Pav K, Edenharder R, and Dunkelberg H (1996) Genotoxicity of selected pesticides in the mouse bone-marrow micronucleus test and in the sister-chromatid exchange test with human lymphocytes in vitro. Toxicological Letters 89(1) 35-42. 

Mouse bone marrow Micronucleus test - Gocke etal, 1981 Katzet al. 1981 ... 

Shimada H. Satake S, Itoh S, et al. 1990. Multiple-dosing effects of benzo[a]pyrene in the mouse bone marrow micronucleus test. Mutat Res 234(3-4) 179-181. 

Antimutagenic activity was observed in mice orally administered 20, 40, or 80 mg/kg of an aqueous extract of saffron three times in 5 days before administration of known mutagens (Premkumar et al. 2001, 2006). Antimutagenic effects of saffron were also observed in the mouse bone marrow micronucleus test with oral doses of 25, 50, and 100 mg/kg (Premkumar et al. 2003), and in the Ames test in Salmonella typhimurium strain TA98 (Abdullaev et al. 2003). 

Marzin, D., and D. Kirkland. 2004. 2-Hydroxy-l,4-naphthoquinone, the natural dye of henna, is non-genotoxic in the mouse bone marrow micronucleus test and does not produce oxidative DNA damage in Chinese hamster ovary cells. Mutat. Res. 560(l) 41-47. 

No mutagenic activity of aqueous or ethanolic extracts of evodia was observed in the Ames test for mutagenicity or in the mouse bone marrow micronudeus test. The Ames test examined effects in Salmonella typhimurium strains TA97, TA98, TAIOO, or TA102. In the mouse bone marrow micronucleus test, animals were administered up to 5 g/kg of the evodia extracts daily for 2 days (Yang 2008). 

Genotoxicity studies were conducted across all product classes and the test batteries used by companies were variable. Twelve of the 15 respondents who completed questionnaires with regard to their strategy for hormones, GFs and CSFs, indicated that that they usually conduct such studies when assessing the safety of these products. In seven of these 12 cases, the studies conducted were those recommended as the ICH test battery, i.e. an in vitro bacterial mutation test, an in vivo mouse bone marrow micronucleus test, and an in vitro chromosome aberration test, either in human peripheral lymphocytes or mammalian cell lines. For four out of these seven cases, these tests were conducted because of regulatory requests. 

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