Chromosome aberration tests

In vitro mammalian chromosome aberration test OECD,US... [Pg.79]

In vitro mammalian cell test (chromosome aberration test or mouse lymphoma assay)... [Pg.4]

In vitro chromosome aberration test In vitro gene mutation assay Acute oral toxicity Acute inhalation or dermal toxicity... [Pg.13]

Ishidate, M., Jr. (1988a). Data Book of Chromosomal Aberration Tests in vitro, Elsevier, Amsterdam. [Pg.230]

In Vitro Mammalian Chromosomal Aberration Test (Updated Guideline, adopted 21 July 1997)... [Pg.21]

Mammalian spermatogonial chromosomal aberration test (August 1998)... [Pg.26]

B.IO Mutagenicity - In Vitro Mammalian Chromosome Aberration Test (20(X))... [Pg.42]

Mammalian bone marrow chromosomal aberration test... [Pg.146]

B.ll Mutagenicity - In vivo mammalian bone-marrow chromosome aberration test B.12 Mutagenicity mammalian erythrocyte micronucleus test B.20 Sex-Unked recessive lethal test in Drosophila melanogaster B.22 Rodent dominant lethal test... [Pg.146]

The in vivo mammalian spematogonial chromosome aberration test OECD TG 483 US-EPA OPPTS 870.5380 EU Annex V B.23... [Pg.149]

Positive results in the mammalian in vivo bone marrow chromosome aberration test indicate that a substance induces stmctural chromosome aberrations in the bone marrow of the species tested. An increase in polyploidy (a multiple of the haploid chromosome number (n) other than the diploid number, i.e., 3n, 4n and so on) may indicate that a substance has the potential to induce numerical aberrations (change in the number of chromosomes from the normal number characteristic of the animals utilized). [Pg.160]

Positive results in the in vivo mammalian spermatogonial chromosome aberration test indicate that a substance induces structural chromosome aberrations in the germ cells of the species tested. This test measures chromosome events in spermatogonial germ cells and is, therefore, expected to be predictive of induction of inheritable mutations in germ cells. [Pg.160]

Positive results from the in vitro chromosome aberration test indicate that the test substance induces structural chromosome aberrations in culmred mammalian somatic cells. More details about this endpoint are provided under the in vivo tests. [Pg.162]

Itoh, S., Nakayama, S. and Shimada, H. (2002) In vitro photochemical clasto-genicity of quinolone antibacterial agents studied by a chromosomal aberration test with light irradiation. Mutation Research, 517, 113-121. [Pg.493]

Ishidate, M., Jr Sofimi, T. (1985) The in vitro chromosomal aberration test using Chinese hamster lung (CHL) fibroblast cells in cnlture. In Ashby, J., de Serres, EJ., Draper, M., Ishidate, M., Jr, Margolin, B.H., Matter, B.E. Shelby, M.D., eds, Progress in Mutation Research, Volume 5, Evaluation of Short-Term Tests for Carcinogens. Report of the International Programme on Chemical Safety s Collaborative Study on in vitro assays, Amsterdam, Elsevier Science, pp. 427M32... [Pg.311]

Matsuoka A, Hayashi M, Ishidate M Jr. 1979. Chromosomal aberration tests on 29 chemicals combined with S9 mix in vitro. Mutation Research 66 277-290. [Pg.201]

Ishidate, M.J. Sofuni, T. (1985) The in vitro chromosomal aberration test using Chinese hamster lung (CHL) fibroblast cells in culture. Prog. Mutat. Res., 5, 427-432... [Pg.98]

Ishidate, M.J.. Sofuni, T. Yoshikawa, K. (1981) Chromosomal aberration tests in vitro as a primary screening tool for environmental mutagens and/or carcinogens. Gann Monogr. Cancer Res., 27, 95-108... [Pg.98]

Ishidate, M., ed. (1988) Revised Edition Data Book of Chromosomal Aberration Test In Vitro, Amsterdam, Elsevier, p. 340... [Pg.1102]

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