Bone-marrow cells

Another dideoxypyrimidine nucleoside active against human immunodeficiency vims is 3 -azido-2/3 -dideoxyuridine [84472-85-5] (AZDU or CS-87, 64) C H N O. Since its synthesis, (167) CS-87 has been identified as a promising antiHIV agent (168) and is currentiy undergoing phase I clinical trials in patients with AIDS and AIDS-related complex. It appears to be less potent than AZT against HIV in a peripheral blood mononuclear (PBM) cell screening system and in MT-4 cell lines. This lower activity in PBM cells appears to be related to a lower affinity of CS-87 for the enzyme responsible for its initial phosphorylation (169). However, CS-87 has significantly lower toxicity on bone marrow cells than AZT (170) and penetration of the CNS as a 5 -dihydropyridine derivative. 

British investigators (Haddow and Timmis 1951) synthesized and studied esters of the methanesulfonic acid. The most active derivative was the dimethylsulfonic ester of 1,4-butanedione, known as busulfan. Busulfan interacts with the thiol groups of proteins and amino acids some of its metabolites can alkylate the thiols of cysteine, peptides and proteins. Busulfan exerts selective cytotoxic activity in hematopoietic bone marrow cells and inhibits the formation of granulocytes and platelets. It slightly affects the lymphoid tissue. 

Glycyrrhiza uralensis X Bone marrow cell proliferating activity [59]... 

Krul CAM (2003a) Dichlorodioctylstannane [CAS 3542-36-7] Micronucleus test in rat bone marrow cells. Zeist, TNO Chemistry, Department of Biomolecular Science, 4 March (TNO Report No. V3404/14). 

Grover IS, Malhi PK. 1985. Genotoxic effects of some organophosphorus pesticides. I. Induction of micronuclei in bone marrow cells in rat. Mutat Res 155 131-134. 

RRE decoy CD34+ bone marrow cells Traps Rev and thus inhibits transactivation of HIV-1 gene expression Kohn et al. 1999... 

RevMlO CD34+ bone marrow cells Inhibits HIV-1 Rev-mediated transactivation of HIV-1 gene expression Podsakoff et al. 2005... 

Ribozyme CD34+ bone marrow cells Specifically cleaves viral RNA Amado et al. 2004... 

Matsumura G, Miyagawa-Tomita S, Shin Oka T, Ikada Y, and Kurosawa H. First evidence that bone marrow cells contribute to the construction of tissue-engineered vascular autografts in vivo. Circulation, 2003, 108, 1729-1734. 

Rat bone marrow cells Chromosomal aberrations B Dikshith and Datta 1978 Dikshith et al. 1978... 

Sano R, Tessitore A, Ingrassia A, d Azzo A (2005) Chemokine-induced recruitment of genetically modified bone marrow cells into the CNS of GMl-gangliosidosis mice corrects neuronal pathology. Blood 106 2259-2268... 

Gao and Yamaguchi, 1999b Mouse bone marrow cells cultured for 7 d with bone resorbing factors (PTH, PGE2, EPS) +/- genistein osteoclast formation assessed by TRAP enzyme Genistein (10 Yi0 M) inhibited osteoclast formation. Mechanism may involve cAMP signalling. 

Gao and Yamaguchi, 1999c Gao and Yamaguchi, 2000 Kajiya et al., 2000 Yamagishi et at., 2001 Bone marrow cells or isolated osteoclasts Suppression of osteoclast formation by genistein is partly due to Ca signalling mechanism and partly due to inhibition of tyrosine kinase activity. 

Rassi et al., 2002 Porcine bone marrow cells measure osteoclast formation (TRAP staining) and activity (pit assay) Daidzein, at the same concentration as estradiol, inhibits osteoclast formation and activity via caspase-3. 

Tobe et al., 1997 Pit assay with mouse bone marrow cells and dentine slices Daidzein (IQ-Yio-iom) stimulated pit formation while genistein had no effect at this concentration. 

Schoeters G, Van Den Heuvel R, Vanderborght O. 1985. The study of damage to bone marrow cells as a biological dosimeter after contamination with osteotropic a emitters. EUR 9250 51-61. 

Potteaux S, Combadiere C, Esposito B, et al. Chemokine receptor CCR1 disruption in bone marrow cells enhances atherosclerotic lesion development and inflammation in mice. Mol Med 2005 11 16-20. 

Oral doses of <5,000 mg/kg Reofos 50 or Reolube HYD46 to male and female Chinese hamsters did not induce significant increases in sister chromatid exchanges in bone marrow cells (Ciba-Geigy 1983b, 1984b). 

Recently, a lectin made from purified elderberry (Sambucus nigra) has been used in the fractionation of normal bone marrow cells. Fractionation minimizes the effects of radiation on normal tissue. This work has been carried out by Dr. Madeleine Mumcuoglu, who patented the elderberry flu formulas, as well as doctors Daphna Manor and Shimon Slavin. There is hope that elderberry contains properties that may have potential in improving the success of bone marrow transplants. 

Deknudt G, Gerber GB. 1979. Chromosomal aberrations in bone-marrow cells of mice given a normal or a calcium-deficient diet supplemented with various heavy metals. Mut Res 68 163-168. 

Tachi K, Nishimae S, Saito K. 1985. Cytogenic effects of lead acetate on rat bone marrow cells. Arch Environ Health 40 144-147. 

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