Metronidazol

Extraintestiaal (eg, hepatic) amebiasis is treated with metronidazole and can be followed by iodoquiaol or a combination of dehydroemetiae or emetine hydrochloride with chloroquiae phosphate. Iodoquiaol is the dmg of choice for asymptomatic amebiasis, whereas ddoxanide furoate (9, Furamide) has been used successftiUy to treat symptomatic and asymptomatic intestinal amebic cyst carriers. [Pg.261]

The infection can be cured most readily with tetracycline (7), oxytetracycline (3), or chlorotetracycline (20). Metronidazole (1) and iodoquinol (2) are also effective. Additional effective dmgs include paromomycin (8), tinidazole (11), sulfadiazine (25), and carbarsone [121 -59-4] (31, -ureidobenzenearsonic acid, CyH AsN204, Ameban). [Pg.264]

Imidazole and imidazoline derivatives have provided some useful antimicrobial compounds (Fig. 7). Metronidazole [433-48-1]... [Pg.133]

Metronidazole — see also Imidazole, 1-(2-hydroxy-ethyl)-2-methyl-5-nitro-antiprotozoal activity, 1, 180 veterinary use, 1, 208 mode of action, 1, 208 Metyrapol metabolism, 1, 234 Metyrapone... [Pg.703]

Methyl silicate, 93 a-Methylstyrene, 93 Methyl-tert-butyl ether, 90 Methyl thiocyanate, 93 Methylthiouracil, 93 Methyltrichlorosilane, 94 Methyl vinyl ketone, 94 Methylal, 89 Metolachlor, 94 Metolcarb, 94 Metorex (Pty) Ltd., 199 Metribuzin, 94 Metronidazole, 94 Mevinphos, 94 Mexacarbate, 94... [Pg.340]

Some of the 7-alkylamiiio- and arylamino-substituted derivatives of l-ethyl-l,4-dihydro-6-iiitro-4-oxo-l,8-iiaphthyridiiie-3-ethylcarboxylate showed nearly the same antibacterial activity as metronidazole against Trichomonas vaginalis (77MI2 79YZ155). [Pg.339]

Alkylation of the 5(4)-nitro compound with methyl sulfate in nonpolar solvents affords dimetridazole (91), ° an antitrichomonal agent used in veterinary practice. Alkylation with chlorohydrin leads to metronidazole (92), a drug that has found widespread use in the treatment of vaginal trichomoniasis. Finally, alkylation by means of iv-(2-chloroethyl)morpholine affords nitrimida-zine (93),... [Pg.240]

Ethylene chlorohydrin (2-chloroethanol) Cloperastine Defosfamide Metronidazole Oxypendyl Ethylenediamine Clonidine HCI Edetate disodium Indanazoline Lofexidine HCI Naphazoline Oxymetazoline HCI Penicillin G Benzathine Tetrahydrozoline HCI Tolazoline Tolonidine nitrate Xylometazoline HCI Ethylene dibromide... [Pg.1633]

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