Metronidazole topical preparations

Topical preparations for the treatment of rosacea include metronidazole 0.75% or 1% cream, 0.75% gel, or lotion. None of these preparations is FDA-approved for ophthalmic use, but they have been beneficial fiar some patients. 

Dose. Established anaerobic infection is treated with metronidazole by mouth 400 mg 8-hourly by rectum 1 g 8-hourly for 3 days followed by 1 g 12-hourly or by i.v. infusion 500 mg 8-hourly. A topical gel preparation is useful for reducing the odour associated with anaerobic infection of fungating tumours. 

Metronidazole is available as oral, topical, and parenteral preparations. 

Tirnaksiz F, Kayi A, (Jelebi N, Adi en E, and Erel A. (2012). Preparation and evaluation of topical microemulsion system containing metronidazole for remission in rosacea. Chemical and Pharmaceutical Bulletin(Tokyo), 60, 583-592. 

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