Drug interactions metronidazole with alcohol

The following drug interactions were reported for metronidazole, a chemically related nitroimidazole. Therefore, these drug interactions may occur with tinidazole. Drugs that may affect tinidazole include cholestyramine, CYP3A4 inducers and inhibitors and oxytetracycline. Drugs that may be affected by tinidazole include alcohols, anticoagulants, cyclosporine, tacrolimus, disulfiram, fluorouracil, hydantoins, and lithium. 

When explaining possible medication and/or food interactions, for example the importance of avoiding alcohol with certain drugs such metronidazole or cheese with monoamine oxidase inhibitors (MAOIs). 

Drugs that may interact with disulfiram include alcohol, benzodiazepines, caffeine, chlorzoxazone, cocaine, hydantoins, isoniazid, metronidazole, theophylline, tricyclic antidepressants, and warfarin. 

An interaction has also been reported in association with metabolic acidosis in an intoxicated man 4 hours after he was given intravenous metronidazole as prophylaxis following injury. A fatality occurred in a frail 31-year old woman, which was attributed to cardiac arrhythmia caused by acetaldehyde toxicity resulting from the alcohol/metronidazole interaction, linked to autonomic distress caused by a physical assault. Alcohol is also said to taste unpleasant or to be less pleasurable while taking metronidazole. Some drug abusers apparently exploit the reaction for kicks . ... 

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