Metronidazole nervous system

Neurologic effects Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, have been reported in patients treated with nitroimidazole drugs including tinidazole and metronidazole. The appearance of abnormal neurologic signs demands the prompt discontinuation of tinidazole therapy. Administer tinidazole with caution to patients with central nervous system diseases. 

Nervous system. Tardive dyskinesias occur with neuroleptics polyneuritis with metronidazole optic neuritis with ethambutol. 

Central nervous system symptoms can occur with standard doses of metronidazole, but they are mainly seen with high doses and especially when such doses are given for a long time. Under the latter conditions, there was a 25% incidence of such sjmptoms as headaches, dizziness, tremor, ataxia, and confusion. 

Kusumi RK, Plouffe JF, and Wyatt RH (1980) Central nervous system toxicity associated with metronidazole therapy. Annals of Internal Medicine 93 59-60. 

Nervous system Three cases of cerebellar toxicity associated with metronidazole have been reported. 

R. S. Alvarez, D. A. Richardson, A. E. Bent and D. R. Ostergard, Central nervous system toxicity related to prolonged metronidazole therapy. Am. 

A. Kuriyama, J. L. Jackson, A. Doi and T. Kamiya, Metronidazole-induced central nervous system toxicity a systematic review, Clin. Neuropharmacol., 2011, 34, 241-247. 

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