Alcohol avoidance metronidazole

Flagyl tablets contain metronidazole. All patients taking metronidazole are advised to avoid alcohol as the combination of alcohol and metronidazole may lead to a disulfiram-like reaction. 

Displacement of GABA from its receptors by ciprofloxacin results in increased levels of the neu-roexcitatory transmitter and acute CNS toxicity. The neuroexcitation can range from irritability, confusion, and agitation to seizures and toxic psychosis. Ciprofloxacin has no interaction with alcohol. A disulfiramlike reaction (flushing, nausea, vomiting, and profuse sweating) is associated with alcohol and metronidazole. Avoid alcohol and metronidazole coadministration. 

A reasonably well studied interaction, but it remains a controversial issue. The incidence is variously reported as between 0 and 100%, with more recent reports disputing its existence. Nevertheless because of the uncertainty, all patients given metronidazole should be warned about what may happen if they drink alcohol. The manufacturer recommends avoidance of alcohol when metronidazole is taken, and for at least 48 hours after it has been stopped.However, the authors of one report suggest a cautious trial of alcohol in patients that are starting and will be taking metronidazole on a chronic basis. 

When metronidazole is prescribed, the nurse warns the patient to avoid the use of alcoholic beverages because a severe reaction may occur. 

Metronidazole is contraindicated in patients with known hypersensitivity. Metronidazole is contraindicated during the first trimester of pregnancy (Category B). Metronidazole is given during the second and third trimesters of pregnancy. Metronidazole is used cautiously in patients with blood dyscrasias, seizure disorders, and severe hepatic impairment. The patient must avoid alcohol while taking metronidazole... 

Educate patients on specific adverse drug effects, particularly with metronidazole (avoidance of alcohol) and bismuth (change in stool color). 

Counsel women taking metronidazole regarding potential for nausea, vomiting, and abdominal pain. Counsel patients to avoid alcohol or alcohol-containing substances during therapy with metronidazole owing to the risk of disulfuram-like reactions. 

Counsel women taking metronidazole to avoid drinking alcohol or using alcohol-containing substances during therapy. 

Patients taking metronidazole should be instructed to avoid alcohol ingestion during therapy and for 1 to 2 days after completion of therapy because of a possible disulfiram-like effect. 

Q52 A patient v/ho is taking metronidazole tablets should be advised to take tablets v/ith or after food and to avoid alcoholic drink. When alcohol is consumed v/ith metronidazole, the patient may present v/ith acute psychoses or confusion. 

Fosamprenavir PI2 1400 mg bid or 700 mg bid with ritonavir 100 bid or 1400 mg daily with ritonavir 100-200 mg daily. Adjust dose in hepatic insufficiency Separate dosing from antacids by 2 h. Avoid concurrent high-fat meals Diarrhea, nausea, vomiting, hypertriglyceridemia, rash, headache, perioral paresthesias, t liver enzymes See footnote 4 for contraindicated medications. Do not administer with lopinavir/ritonavir or in severe hepatic insufficiency. Also avoid cimetidine, disulfiram, metronidazole, vitamin E, ritonavir oral solution, and alcohol when using the oral solution... 

Adverse effects include nausea, diarrhea, stomatitis, and peripheral neuropathy with prolonged use. Metronidazole has a disulfiram-like effect, and patients should be instructed to avoid alcohol. Although teratogenic in some animals, metronidazole has not been associated with this effect in humans. Other properties of metronidazole are discussed in Chapter 52. 

Alcohol should be avoided during furazolidone and metronidazole therapy. Toxic psychosis has been seen in patients under treatment with furazolidone. Metronidazole should be used with caution when coadministering with warfarin, phenytoin, lithium, omeprazole, and phenobarbital. The coadministration of pentamidine with drugs toxic to the kidney should be avoided. 

METRONIDAZOLE ALCOHOL Disulfiram-like reaction Metronidazole inhibits aldehyde dehydrogenase Avoid co-ingestion... 

ALCOHOL METRONIDAZOLE Disulfiram-like reaction. Unsteadiness, and incoordination caused by metronidazole may be aggravated by alcohol Metronidazole inhibits aldehyde dehydrogenase. Additive side-effects Avoid co-ingestion... 

Avoid all alcohol-containing products while taking metronidazole... 

When explaining possible medication and/or food interactions, for example the importance of avoiding alcohol with certain drugs such metronidazole or cheese with monoamine oxidase inhibitors (MAOIs). 

Metronidazole (Flagyl) Amebiasis Gl Nausea, anorexia. Avoid alcohol alcohol 9, 24, 54-59... 

---