Dizziness metronidazole

Various studies demonstrate the successful use of tinida-zole for metronidazole-resistant trichomoniasis.19 Possible side effects include a metallic taste, dizziness, loss of coordination, seizures, severe diarrhea, darkened urine, nausea, vomiting, and a swollen or discolored tongue. 

Oxidation of acetaldehyde is inhibited by disulfiram, a drug that has been used to deter drinking by alcohol-dependent patients undergoing treatment. When ethanol is consumed in the presence of disulfiram, acetaldehyde accumulates and causes an unpleasant reaction of facial flushing, nausea, vomiting, dizziness, and headache. Several other drugs (eg, metronidazole, cefotetan, trimethoprim) inhibit ALDH and can cause a disulfiram-like reaction if combined with ethanol. 

Carnidazole is an imidazole derivative, less potent than most other similar compounds (1). In early studies, its adverse effects were mild nausea and vomiting, abdominal discomfort, dry mouth, dizziness, headache, and tiredness were reported (SEDA-6,264). Metronidazole-Uke adverse effects should be anticipated. 

The efficacy of triple therapy with bismuth plus amoxicillin and metronidazole has been assessed in an open trial in 26 children with duodenal ulcers associated with H. pylori (15). Helicobacter pylori was eradicated in 25 children and the ulcer was healed in 24. During a mean follow-up of nearly 2 years, the annual ulcer relapse rate was 9% (compared with 56% in historical controls, in whom the infection was not eradicated). Adverse events were reported by 13% of the children, and included diarrhea, dizziness, nausea, and vomiting. 

Central nervous system symptoms can occur with standard doses of metronidazole, but they are mainly seen with high doses and especially when such doses are given for a long time. Under the latter conditions, there was a 25% incidence of such sjmptoms as headaches, dizziness, tremor, ataxia, and confusion. 

Toxicity Adverse effects include gastrointestinal irritation, headache, and dark coloration of urine. More serious toxicity includes leukopenia, dizziness, and ataxia. Drag interactions with metronidazole include a disulfiram-like reaction with ethanol and potentiation of coumarin anticoagulant effects. Although it is not contraindicated in pregnancy, the drug should be used with caution. 

A woman taking carbamazepine 1 g daily started taking co-trimoxazole twice daily and metronidazole 250 mg three times daily for diverticulitis. After 2 days the co-trimoxazole was stopped, she was changed to intravenous metronidazole 500 mg three times daily, and cefazolin 500 mg every 8 hours. After 2 days she complained of diplopia, dizziness and nausea, and her serum carbamazepine levels were found to have risen from 9 to 14.3 micrograms/mL. A month later (presumably after the metronidazole had been withdrawn) her serum carbamazepine levels had fallen to 7.1 micrograms/mL. The reasons for this reaction are not understood. This appears to be the first and only report of an interaction between car-... 

Comparative studies Oral moxifloxacin for 2 weeks has been compared with levofloxacin -I- metronidazole in 460 women with uncomplicated pelvic inflammatory disease [41 ]. Clinical and bacteriological efficacies were comparable nausea (19% and 23%) and dizziness (16% and 15%) in the moxifloxacin and comparator groups were the most common adverse events. One moxifloxacin-treated subject developed Stevens—Johnson syndrome. 

Metronidazole is reduced xmder anaerobic conditions to a compound that prevents DNA synthesis. Adverse effects associated with metronidazole include nausea, diarrhoea, weight loss, abdominal pain, vomiting, headache, dizziness and metallic taste in the moutii. 

A 69-year-old woman presented with sudden onset of left facial drop, dizziness, slurred speech and impaired balance [35 ]. History included paroxysmal atrial fibrillation and a sigmoid diverticular abscess treated with ciprofloxacin and metronidazole. Cranial CT angiography and MRI showed no signs of ischaemia or haemorrhage but demonstrated symmetrically distributed lesions in the cerebellar dentate nuclei. A diagnosis of metronidazole-induced encephalopatiiy was suspected and the drug withdrawn. Patient made uneventful recovery. 

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