Contact dermatitis metronidazole

Femandez-Jorge B, Goday J, Buja N, Fer-nandez-Torres R, Rodriguez-Lojo R, Fonseca E. Concomitant allergic contact dermatitis from diphenhydramine and metronidazole. Contact Dermatitis 2008 59 115-6. 

C. Vincenzi, P. Lucente, C. Ricci and A. Tosti, Facial contact dermatitis due to metronidazole. Contact Dermatitis, 1997, 36, 116-117. 

Fernandez-Jorge +, Contact Dermatitis 59(2), I 15 (with metronidazole)... 

Ortiz PG, Hansen SH, Shah VP, Menne T, Benfeldt E. The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method. Contact Dermatitis. 2008 59 23-30. 

The authors concluded that the patient had had allergic contact dermatitis due to both metronidazole and diphenhydramine. 

Skin Contact dermatitis, a rare manifestation of topical metronidazole, has been reported in two nurses [29 ]. 

Madsen JT, Lorentzen HF, Paulsen E. Contact sensitization to metronidazole from possible occupational exposure. Contact Dermatitis 2009 60(2) 117-8. 

Metronidazole is a contact sensitising agent and it has resulted in contact dermatitis in patients and in those occupationally exposed to it. It has also resulted in serum sickness and fixed drug eruptions. 

J. T. Madsen, J. Thormann, S. Kerre, K. E. Andersen and A. Goossens, Allergic contact dermatitis to topical metronidazole - 3 cases. Contact Dermatitis, 2001, 56, 364-366. 

Miconazole was originally marketed only for topical use in a 2% cream, lotion and powder. Allergic contact dermatitis to miconazole has recently been described. De Greef et al. (16 ) noted aggravation in 8 of 108 patients treated with the 2% cream, of whom one had a positive patch test to 2% miconazole. Van Ketel(17 -) described patch tests in one patient with a clinical reaction to the cream after 6 weeks use, with a positive patch test to 2% miconazole in vaseline and negative tests to the related imidazole derivatives mebendazole, tinidazole and metronidazole. 

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