Tolonidine Nitrate

Chemical Name N-(2-Chloro-4-methylphenvl)-4,5-dihvdro-1 H-imidazol-2-amine Common Name — 

2-Chloro-4-methylaniline Methyl iodide Nitric acid 

It was identified to be 2-(2 -chloro-4 -methylphenyl)-amino-1,3-diazacyclopentene-(2) of the formula 

The nitrate of the base, obtained by acidifying a solution of the free base with nitric acid, had a melting point of 162°C to 164°C and was soluble in water and methanol. 

Hauptmann, K.H. and Stable, H. U.S. Patent 3,236,857 February 22, 1966 and U.S. Patent 3,454,701 July 8, 1969 both assigned to Boehringer Ingelheim GmbH (Germany) 

2-Chloro-4-methy (aniline Methyl iodide Nitric acid 

Obtained in known fashion from 2-chloro-4-methylanilineandammonium thiocyanate and 20 cc of methyl iodide were dissolved in 200 cc of methanol, and the solution was refluxed for two hours. Thereafter, the solvent was evaporated in vacuo, leaving 73.2 g of the iso-thiouronium hydroiodide of the formula 

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Phethenylate sodium Ammonium chloride Cyclofenil Methionine Ammonium sulfate Aminobenzoic acid Fibrinolysin Ammonium sulfamate Cyclamate calcium Ammonium thiocyanate Acetazolamide Clonidine HCl Tolonidine nitrate 2oxazo lamina d-Amphetamine Tanphetamin Ampicillin Mezlocillin Talampicillin... 

Ethylene chlorohydrin (2-chloroethanol) Cloperastine Defosfamide Metronidazole Oxypendyl Ethylenediamine Clonidine HCI Edetate disodium Indanazoline Lofexidine HCI Naphazoline Oxymetazoline HCI Penicillin G Benzathine Tetrahydrozoline HCI Tolazoline Tolonidine nitrate Xylometazoline HCI Ethylene dibromide... 

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