Metronidazol vaginal gel

Ferris DG, Litaker MS, Woodward L, Mathis D, Hendrich J Treatment ofbacterial vaginosis A comparison of oral metronidazole, metronidazole vaginal gel and clindamycin vaginal cream. J Fam Pract 1995 41 443-449. 

DuBouchet, L., et al. 1998. A pilot study of metronidazole vaginal gel versus oral metronidazole for the treatment of Trichomonas vaginalis vaginitis. Sex Transm Dis 25 176. 

Wain AM. Metronidazole vaginal gel 0.75% (MetroGel-Vaginal) a brief review. Infect Dis Obstet Gynecol 1998 6(l) 3-7. 

Metronidazole Tablet Cores (400 mg) Metronidazole Tablets (200 mg) Metronidazole Tablets (500 mg) Metronidazole Vaginal Gel (1.2%) Miconazole Cream (2%)... 

Anukam KC, Osazuwa E, Osemene Gl, Ehigiagbe F, Bruce AW, Reid G. Clinical study comparing probiotic Lactobacillus GR-1 and RC-14 with metronidazole vaginal gel to treat symptomatic bacterial vaginosis. Microbes and Infection. 2006 8(12) 2772—2776. 

Simbar. M.. Azarbad. Z.. Mojab, E., Alavi Majd, H. 2008. A comparative study of the therapeutic effects of the Zataria multi ora vaginal cream and metronidazole vaginal gel on bacterial vaginosis. Phvtomedicine 15(12) 1025-1031. 

Metronidazole is indicated for treatment of anaerobic or mixed intra-abdominal infections, vaginitis (trichomonas infection, bacterial vaginosis), C difficile colitis, and brain abscess. The typical dosage is 500 mg three times daily orally or intravenously (30 mg/kg/d). Vaginitis may respond to a single 2-g dose. A vaginal gel is available for topical use. 

Metronidazole has been formulated as a vaginal gel (0.75%) for the treatment of bacterial vaginosis. A single daily 5-day regimen has been approved by the FDA and has been shown to be as effective as oral metronidazole (1). 

Treatment failures owing to metronidazole-resistant strains of T. vaginalis are increasingly common. Most cases can be treated successfully by giving a second 2-g dose to both patient and sexual partner. In addition to oral therapy, the use of a topical gel containing 0.75% metronidazole or a 500- to 1000-mg vaginal suppository may be beneficial in refractory cases. 

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