Sucralfate Metronidazole

Because oral triple therapy to eradicate H. pylori using sucralfate instead of bismuth has yielded inconsistent results, a 5-day study was undertaken in 14 healthy subjects to investigate whether sucralfate interacts with metronidazole. It was found that sucralfate 2 g twice daily had no effect on the pharmacokinetics of a single 400-mg dose of metronidazole. Sucralfate would therefore not be expected to alter the effects of metronidazole. 

Amaral Moraes ME, De Almeida Pierossi M, Moraes MO, Bezerra FF, Ferreira De Silva CM, Dias HB, Muscara MN, De Nucci G, Pedrazzoli J. Short-term sucralfate administration does not alter the absorption of metronidazole inhealdiy male volunteers. IntJ Clin Pharmacol Ther (1996) 34, 433-7. 

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