Metallic taste metronidazole

Metronidazole maybe administered orally as a single 2-g dose or 500 mg twice daily for 7 days.17 Pregnant women should be prescribed the single dose of metronidazole. Cure rates are greater than 90% when metronidazole is administered as either a single 2-g dose or a 7-day regimen. Possible adverse effects include an unpleasant metallic taste, reversible neutropenia, urticaria, rash, flushing, dry mouth, darkened urine, and a disulfiram-like reaction. 

Various studies demonstrate the successful use of tinida-zole for metronidazole-resistant trichomoniasis.19 Possible side effects include a metallic taste, dizziness, loss of coordination, seizures, severe diarrhea, darkened urine, nausea, vomiting, and a swollen or discolored tongue. 

Metronidazole Nausea/vomiting Metallic taste Refrain from using alcoholic beverages potential for disulfiram-like reaction Substrate for CYP2C9 and inhibitor of CYP2C9, 3A3/4 and 3A5-7 potential interactions may include warfarin (enhanced prothrombin time) and lithium (increased concentrations)... 

Metronidazole (Flagyl, Antibiotic Tab 250, 375, 500 mg 250-750 mg tid X 7 days disutfiram-like reaction, metallic taste. 

There are a number of factors that limit the effectiveness of regimens designed to eradicate H. pylori. The first, antibiotic resistance, is seen with metronidazole and clarithromycin but has not been reported with bismuth, amoxicillin, or tetracycline. Second, mild adverse effects (eg, diarrhea, metallic taste, black stools) do occur in approximately 30% to 50% of patients. Therefore, shorter treatment periods in this group of patients may be better tolerated. 

Corticosteroids are commonly prescribed for moderate to severe Crohn s disease with short term efficacy probably related to their effect on inflammation. Anti-bacterials are commonly used as primary therapy in Crohn s disease. Common adverse effects of metronidazole are nausea and a metallic taste, hov ever peripheral neuropathy may result from long term use. Ciprofloxacin and similar antibacterials can be beneficial in those patients intolerant to mefi onidazole. 

Ranitidine 300 mg bd and omeprazole 20 mg bd have been compared as components of triple therapies (combining them with either amoxicillin plus clarithromycin or amoxicillin plus metronidazole) in 320 patients with H. pylori (5). Omeprazole and ranitidine combined with two antibiotics for 1 week were equally effective in eradicating H. pylori. This result questions the role of profound acid suppression in eradication. There was no difference in the reported adverse effects, which included nausea, vomiting, diarrhea, metallic taste, skin rashes, and headache. 

Anorexia, nausea, vomiting, abdominal pain, and diarrhea have all been reported in patients taking metronidazole (14). The use of a large single dose most commonly leads to these complaints. A metallic taste also seems to be quite common (14), as is the occurrence of a black tongue (SEDA-13, 832) (15). 

In a randomized trial in 100 Iranian children, mebendazole (200 mg tds for 5 days, n — 50) was compared with metronidazole (5 mg/kg tds for 7 days, n = 50) in giardiasis (32). The two drugs were equally effective (over 85% cure rates). There were no adverse effects of mebendazole, whereas nausea, anorexia, and metallic taste were respectively observed in 4.9, 6, and 24% of those taking metronidazole. 

Metronidazole is a well tolerated drug causing expulsion or lysis of the guinea worms. However, the patient may experience nausea, vomiting, weakness, insomnia, headache, dry mouth and metallic taste. 

Most patients receiving metronidazole for Crohn s disease tolerate the agent fairly well however, mild adverse effects occur frequently. They commonly include paresthesias and reversible peripheral neuropathy, metallic taste, urticaria, and glossitis. Other effects include a disulflram-like reaction if alcohol is ingested in conjunction. 

Metronidazole is reduced xmder anaerobic conditions to a compound that prevents DNA synthesis. Adverse effects associated with metronidazole include nausea, diarrhoea, weight loss, abdominal pain, vomiting, headache, dizziness and metallic taste in the moutii. 

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