Metronidazole chemistry

Some data on the application of nitroazole derivatives have been mentioned in reviews and monographs on the chemistry of nitroazoles [1], pyrazoles [2], furox-ans [3], benzimidazole [4], and benzotriazole [5, 6], etc. Special monographs and reviews have been devoted to biological and clinical application of different nitroimidazoles [7-23] and chemotherapy of metronidazole [24], Therefore, it is not given much attention to metronidazole here. 

Nitroazoles are compounds of very considerable commercial and chemotherapeutic importance. The introduction of metronidazole, dimetridazole, and their condensed analogs has stimulated much synthetic chemistry of nitroazoles resulting in the discovery of a number of compounds that are important for the treatment of different human and/or animal diseases. 

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