Mebendazole Metronidazole

ABSTRACT. The bioavailahility of pharraaca which dissolve in water only with difficulty is very limited. The cyclodextrins /CDs/, and primarily A-Ct) and CD, were successfully applied to increase the dissolution characteristics and hence the bioavailahility of drugs furosemide, hydrochlorothiazide, mebendazole, metronidazole, spironolactone, tofisopam, vinpocetine base, etc. Prom these pharraaca, products were made by mixing, kneading, grinding, freeze-drying, spray-embedding and precipitation. 

Dracunculus medinensis (guinea worm) Metronidazole Thiabendazole or mebendazole... 

Guinea worm /rJcdiYJcnsJS metronidazole, mebendazole Rapid symptom relief... 

In a randomized trial in 100 Iranian children, mebendazole (200 mg tds for 5 days, n — 50) was compared with metronidazole (5 mg/kg tds for 7 days, n = 50) in giardiasis (32). The two drugs were equally effective (over 85% cure rates). There were no adverse effects of mebendazole, whereas nausea, anorexia, and metallic taste were respectively observed in 4.9, 6, and 24% of those taking metronidazole. 

Sadjjadi SM, Alborzi AW, Mostovfi H. Comparative clinical trial of mebendazole and metronidazole in giardiasis of children. J Trop Pediatr 2001 47(3) 176-8. 

The imidazoles comprise a large and diverse group of compounds with properties encompassing antibacterial (metronidazole), antiprotozoal (metronidazole), antifungal (clotrimazole, miconazole, ketoconazole, econazole) and anthelmintic (mebendazole) activity see Table 10.4. 

Metronidazole has been shown to be of great value in the management of anaerobic bacterial infections [20,27,75,76]. The role of this drug in the prophylaxis and treatment of various anaerobic bacterial infections, which may develop following appendectomy, elective colonic surgery, colo-rectal surgery and hysterectomy [20,77,78]. Mebendazole is equally useful in cases of endocarditis, osteomyelitis, lung abscess, empyema, peritonitis, septicemia and pelvic infections [79]. 

Metronidazole (Flagyl) is used for both bacterial (commonly for dental infections) and some protozoan infections, such as amoebic dysentery. Benzimidazoles, such as mebendazole (Pripsen), are an important group of anthelmintics. The most common anti-fungal agents are triazoles such as fluconazole (Diflucan). 

Mebendazole binds to tubulins to alter the transport functions of microtubules Metronidazole is activated in the parasite to a cytotoxic product Salicylhydroxamic acid is an inhibitor of glycerol-3-phosphate oxidase Sulfonamides inhibit 7,8-dihydropteroate synthase Which one of the following enzymes is not unique to parasites ... 

A case control study was conducted in an attempt to identify risk factors associated with an outbreak of Stevens-Johnson syndrome/toxie epidermal neeroly sis that occurred amongst Filipino workers in Taiwan. The risk of developing this serious condition was significantly higher in workers who had taken both metronidazole and mebendazole sometime in the preceding 6 weeks (odds ratio of 9.5). In addition, there was an increase in risk with higher doses of metronidazole. ... 

The information is limited to this report, which does not establish an interaction. However, Stevens-Johnson syndrome/toxic epidermal necrolysis is a serious condition, and therefore, the manufacturer of mebendazole states that the concurrent use of mebendazole and metronidazole should be avoided. Caution would certainly seem appropriate if both drugs are considered essential. 

Miconazole was originally marketed only for topical use in a 2% cream, lotion and powder. Allergic contact dermatitis to miconazole has recently been described. De Greef et al. (16 ) noted aggravation in 8 of 108 patients treated with the 2% cream, of whom one had a positive patch test to 2% miconazole. Van Ketel(17 -) described patch tests in one patient with a clinical reaction to the cream after 6 weeks use, with a positive patch test to 2% miconazole in vaseline and negative tests to the related imidazole derivatives mebendazole, tinidazole and metronidazole. 

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