Factors to Consider in Evaluation

Factors to consider in evaluating the selection between induced and forced draft include the following ... 

Migration experiments have shown that the hydrated cations not only carry with them the water in the inner coordination sphere, but also one or more shells of additional water molecules, for typical total values of 10-15. When the metal ion leaves the aqueous phase in the solvent extraction step, this ordered coordinated water returns to the bulk water structure, contributing an additional factor to consider in evaluating the thermodynamics of extraction. 

A primary factor to consider in evaluation is the age of the patient. Changes in the anatomy and physiology of skin and its appendages relate closely to patient age, and for women hormonal status also affects the evaluation. 

Scheme 3.27. Factors to consider in evaluating reactions of chiral organo-lithiums.

Many different methods have been used to evaluate the antioxidant capacities of isolated molecules, carotenoids, and other natural antioxidants and of foods and food extracts containing antioxidants. It is not the purpose of this chaper to review all the methods, but some general points can be made. First, when using only one test to evaluate the antioxidant capacities of carotenoids, one should be very careful in the interpretation of obtained data. Indeed, different results can be obtained with different tests applied to the same molecules. At least two different methods should be used to evaluate the antioxidant activity of a molecule or a food extract. " Second, lipophilicity is an important factor to consider in testing the antioxidant activities... 

In the plant used for academic purposes [4], both the solvent and exhausted CO2 are wasted. In an industrial plant both streams should be recycled after purification, for obvious economic reasons. The precipitator size and plant-flow-rates are obtained by increasing 80-fold the relative quantities used in the pilot plant [4]. This scale factor was suggested by the company that supplied the drug. Two vessels, P, in parallel are needed while the former is running, the latter can be cleaned and the solid product can be recovered. Cleaning and product-recovery expenses are not directly evaluated in this example. In the pilot plant, the flow of THF-polymer-drug solution was 0.072 kg/h, and the CO2 flowed in the quantity of 1.08 kg/h (the ratio CO2 to solution equals 15). The precipitator was a 0.4-liter vessel. The actual precipitator scale-up is not considered here. The main factor to consider in scaling-up the precipitator is the nozzle scale-up. The nozzle-size, nozzle-shape, and number of nozzles per reactor volume, determine the precipitate size in a complex and still incompletely understood way [5-8], It is assumed that issues related to the injectors are already solved. 

While there are several factors to consider in the level of qualification conducted, including the type of vendor or supplier, the scope of work involved in the contract, and the amount of risk associated with the outcome of the project, the evaluation of each of these factors is manageable. The use of a decision matrix is probably the most effective tool in completing this evaluation. An example of a decision matrix is illustrated in Table 1. 

Important factors to consider when evaluating indirect effects include interspecies interactions (e.g., competition, disease), trophic-level relationships (e.g., predation), and resource utilization. Effects on higher (or lower) organizational levels depend on the severity of the effect, the number and life stage of organisms affected, the role of those organisms in the community or ecosystem, and ecological compensatory mechanisms. 

Environmental Factors. Clearly, discovery of an extraordinarily permeable and selective material that can survive only weeks or months in the required operating environment will be unacceptable. The present brief discussion suggests approaches to consider in evaluating environmental challenges to a candidate material. Such tests should be performed in parallel with detailed sorption and transport measurements soon after a candidate material is found to have desirable selectivity and permeability properties. 

In fine and specialty chemicals production the process cost is a less relevant aspect on the other hand, the time taken to realize the industrial production is typically the critical factor. This aspect, together with the limited resources dedicated for R D, determine the preference in companies for multipurpose catalysts with respect to optimized, but more specific, catalysts. This applies also to the process itself where simpler, not optimized, batch reactors are preferred to better, but less flexible, more complex operations. This is one of the key aspects to consider in evaluating the use of multiphase operations in the synthesis of this class of chemicals. 

Because of the many detrimental effects associated with chronic steroid therapy, dose minimization has been the goal of therapy. The availability of CSA, TAC, and mycophenolate mofetil has permitted complete withdrawal of corticosteroids in some patients. Steroid withdrawal protocols use either a rapid taper of steroids within days of the transplant or a slower taper, whereby patients are weaned gradually from steroids over months to years after transplant. Factors to consider when evaluating smdies of these alternative strategies in transplant patients include patient selection criteria, timing and rapidity of withdrawal, and duration of follow-up. 

It has been now recognised that die phenolic profile of the foods, along with high intakes of the monounsaturated fatty acids, as oleic acid mainly, confers its health-promoting properties to die Mediterranean diet. In fact, olive oil is the main source of unsaturated acids and polyphenols that constitute a complex mixture in olive fruits and in its derived products. In addition, in O. europaea fruits, phenolic profile and content are important factors to consider in order to evaluate virgin olive oil quality. To remain that they are also partly responsible for autoxidation stability and organoleptic characteristics of olive oil. 

Plaa. G. L and Vezina, M. (1990). Factors to consider in the design and evaluation of chemical interactions studies in laboratory animals. In Toxic Interactions (R. S. Goldstein, W. R. Hewitt, and J, B. Hook. Eds,), pp. 3-30, Academic Press, New York. 

Another important factor to consider in any quality control program is personnel. Procedures should be established to verify qualifications, provide and evaluate continuous training, and assess and document job performance. Education and training are essential to maintaining competency. Those individuals who perform the processes within research and development and those responsible for monitoring and control should be qualified, properly trained, and understand the accepted standards and guidelines. There must be a commitment on the part of employees to abide by them as well. 

TABLE 9 Factors to Consider in Selecting Usability-Evaluation Techniques... 

The level of environmental resistance required and equipment available may determine whether to evaluate primer/cover coat systems versus one coat adhesive systems. And last, but not least, cost of both the adhesive and the application process is an important factor to consider in any industrial application, rubber to metal bonding being no exception. 

Moreover, it is not sufficient to determine the hazard potential of a solvent based on toxicological effects alone. Other components to consider in evaluating potential hazard are vapor pressure, flammability, ventilation, handling procedures, volume, aud air concentration. Other factors that contribute to exposure through skin contact and absorption include handling procedures and the type of clothing worn. There are also safety considerations such as the potential for ignition, flammabflity, and explosion that contribute to the hazard potential. 

Irritable bowel syndrome There is a rationale for investigating the effect of probiotics in the treatment of this common disorder where intestinal motility and dysfunctions in the intestinal microflora are important factors to consider. In a recent study using L. plantarum 299v, a reduction of symptoms was reported. Enterococcus faecium preparations have also been evaluated for the treatment of patients with irritable bowel syndrome, and although patient-recorded symptoms did not show significant differences, the physician s subjective clinical evaluation revealed an improvement. 

Site Selection Factors that must be considered in evaluating potential sites for the disposal of hazardous waste are covered in state and federal regulations. In Cahfornia, landfills where hazardous wastes can be received are referred to as Class I disposal sites. To quahfy as a Class I site, it must be shown that ... 

According to the literature [77], a process is considered to be low hazard from the thermal standpoint if the normal operating temperature or temperature due to upset is 50°C or more lower than the ARC onset temperature, and the maximum process temperature is held for only a short period of time. However, other factors must be considered in evaluating the thermal hazard of a process such as total enthalpy of reaction or decomposition, potential for reactant accumulation, the boiling point of the reaction mass, and the rate of reaction. The testing must involve all appropriate materials including reactants, intermediates, and products. In some cases, though, the 50°C differential... 

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