Dermatomyositis association

Polymyositis and Dermatomyositis Syndromes Polymyositis and Dermatomyositis Associated with Malignancy Inclusion Body Myositis (IBM)... 

Douglas WW, Tazelaar HD, Hartman TE, et al. Pol3miyositis-dermatomyositis-associated interstitial lung disease. Am J Respir Crit Care Med 2001 164 1182-1185. 

Selva-O Callaghan A, Labrador-Honillo M, Munoz-GaU X, et al. Polymyositis/ dermatomyositis-associated lung disease analysis of a series of 81 patients. Lupus 2005 14 534-542. 

Fall N, Bove KE, Stringer K, et al. Association between lack of angiogenic response in muscle tissue and high expression of angiostatic ELR-negative CXC chemokines in patients with juvenile dermatomyositis possible link to vasculopa-thy. Arthritis Rheum 2005 52(10) 3175-3180. 

One of the primary reasons ultraviolet radiation is of interest in the context of autoimmune diseases is because of induction of photosensitive cutaneous lesions (cutaneous lupus erythematosus)82 and dermatomyositis.83 A recent global evaluation of the frequency of dermatomyositis and associated autoantibodies in referral centers around the world showed a positive correlation with the intensity of ultraviolet irradiation at those locations.84... 

Positive association with frequency of dermatomyositis in one study inverse association with risk of diabetes and MS. Inhibition of disease in rodent models of multiple sclerosis, type 1 diabetes and inflammatory bowel disease but acceleration... 

Hepatotoxicity Penicillamine has been associated with a mild elevation of hepatic enzymes that usually returns to normal even with continuation of the drug. Autoimmune syndromes Autoimmune syndromes that may be caused by penicillamine include polymyositis, diffuse alveolitis and dermatomyositis, Goodpasture s syndrome, myasthenic syndrome, pemphigus, and obliterative bronchiolitis. 

The autoimmune rheumatic diseases consists of Rheumatoid Arthritis (RA), Spondylarthritis (SpA), Systemic Lupus Erythematosus (SLE), Polymyositis, Dermatomyositis, Polymyalgia Rheumatica, Acute Temporal Arteritis, Giant Cell Arteritis, Behcet s Disease, Sjorgren s Syndrome, Felty s Syndrome and Mixed Connective Tissue Disease (MCTD). Spondylarthritis (SpA) can be subdivided in Reactive Arthritis (ReA), Ankylosing Spondylitis (AS), Psoriatic Arthritis (PsA), Arthritis associated with the inflammatory bowel diseases are Crohn s disease and Ulcerative Colitis (IBD), Undifferentiated SpA (UspA) and Sacro-ilitis, Juvenile SpA and Acute Anterior Uveitis (AAU). 

The term classical PNS is reserved for the PNS in which the association with cancer is common and includes encephalomyelitis, limbic encephalitis, paraneoplastic cerebellar degeneration, and paraneoplastic opsoclonus myoclonus (OM), as well as sensory neuronopathy (SN), chronic gastrointestinal pseudo-obstruction, Lambert Eaton myasthenic syndrome (LEMS), and dermatomyositis [14]. This chapter does not include dermatomyositis. 

Similar serum enzyme elevations are found in polymyositis (A3, B4a, B20, D2, D17, E5, H7, KIO, M15, M18, Pl, P4, P5, P7, R15, S15, S26, T8, W12, W19), a nonspecific inflammatory myopathy sometimes associated with neoplastic disease but in general related to the collagen diseases and likewise responsive to corticosteroid therapy. The condition occurs at all ages in both sexes, may be acute or insidious with perhaps a normal erythrocyte sedimentation rate, may or may not be painful, or may be accompanied by an erythematous rash (dermatomyositis). Characteristically the earliest appearance of weakness is in the muscles of the pelvic... 

Vela-Casasempere P, Borras-Blasco J, Navarro-Ruiz A. Alfuzosin-associated dermatomyositis. Br J Rheumatol 1998 37(10) 1135-6. 

Arumalon (Rumalon) (SEDA-14, 440) is a glycosamino-glycan-peptide complex, a chondroprotective agent containing a watery extract of cartilage and an extract of the red bone marrow of calves. Parenteral use has been associated with local reactions at the site of the injection and with allergic symptoms (such as fever, malaise, sjmp-toms of pronounced inflammation, nephrotic syndrome). Polymyositis and fatal dermatomyositis are also alleged to be associated with it. 

Kamel OW, van de Rijn M, LeBrun DP, Weiss LM, Warnke RA, Dorfman RE. Lymphoid neoplasms in patients with rheumatoid arthritis and dermatomyositis frequency of Epstein-Barr virus and other features associated with immunosuppression. Hum Pathol 1994 25(7) 638 3. 

According to Verity et al.,43 the described pathologic changes in skin, fascia, and muscle, along with the defined clinical syndrome of EMS, allow for an accurate differentiation from related syndromes, including eosinophilia polymyositis, scleroderma, idiopathic polymyositic/dermatomyositis, polyarteritis nodosa, and toxic oil syndrome.43 A few reports have considered the comparison of the histopathologic features of Shulman s syndrome (diffuse fasciitis with eosinophilia) and the fasciitis associated with EMS.43... 

Acebutolol Alpha-methyl-dopa Captopril Carbimazole Chlorpromazine Dihydralazine Fludarabine Hydralazine Infliximab Interferons-alpha Iproniazid Isoniazid Nomifensine Penicillamine D-Penicillamine Practolol Procainamide Propylthiouracil rlL-2 Simvastatin Tienilic acid Tryptophan contaminants Zimeldine Lupus syndrome Autoimmune haemolytic anaemia Pemphigus ANCA-associated vasculitis Lupus syndrome Autoimmune hepatitis Autoimmune haemolytic anaemia Lupus syndrome, ANCA-associated vasculitis Lupus syndrome Wide range of autoimmune diseases Autoimmune hepatitis Lupus syndrome Autoimmune haemolytic anaemia Myasthenia, dermatomyositis Anti-GBM (Goodpasture) disease Oculocutaneomucous syndrome Lupus syndrome ANCA-associated vasculitis Autoimmune thyroiditis Lupus syndrome Autoimmune hepatitis Eosinophilia myalgia syndrome (see section 9.3.5) Guillain-Barre syndrome... 

Myositis, autoimmune. Rare systemic inflammatory myopathies, including primary polymyositis, primary dermatomyositis, myositis associated with malignancy, childhood dermatomyositis, and myositis with multisystem autoimmune disease (e.g. mixed connective tissue disease, systemic sclerosis). Autoantibodies against aminoacyl-tRNA synthetases (e.g. anti-Jo-1), signal recognition particle (e.g. anti-SRP54), nuclear helicase (anti-Mi-2), tRNA and tRNA-protein complexes (e.g. anti-Mas), and translation factor (anti-KJ) have been described as myositis specific. 

Manlhiot C, Tyrrell PN, Liang L, Atkinson AR, Lau W, Feldman BM. Safety of intravenous immunoglobulin in the treatment of juvenile dermatomyositis adverse reactions are associated with immunoglobulin A content. Pediatrics 2008 121(3) e626-30. 

Somani A-K, Swick AR, Cooper KD, McCormick TS. Severe dermatomyositis triggered by interferon beta-la therapy and associated with enhanced type i interferon signaling. Arch Dermatol 2008 144 (10) 1341-9. 

Arakawa H, Yamada H, Kurihara Y, et al. Nonspecific interstitial pneumonia associated with polymyositis and dermatomyositis serial high-resolution CT findings and functional correlation. Chest 2003 123 1096-1103. 

Figure 11 (A) and (B) Acute phase of diffuse alveolar damage pattern in a patient with dermatomyositis. The lung shows interstitial and intra-alveolar edema associated with fibrinous exsudate and hyaline membranes (arrow). A, HES 40x. Inset Alveolar duct is filled with loose fibro-inflammatory plug extending within adjacent airspaces. B, HES 40x.

Ideura G, Hanaoka M, Koizumi T, et al. Interstitial lung disease associated with amyopathic dermatomyositis review of 18 cases. Respir Med 2007 101 1406-1411. 

Suda T, Fujisawa T, Enomoto N, et al. Interstitial lung diseases associated with amyopathic dermatomyositis. Eur Respir J 2006 28 1005-1012. 

Frazier AR, Miller RD. Interstitial pneumonitis in association with polymyositis and dermatomyositis. Chest 1974 65 403-407. 

Yamasaki Y, Yamada H, Nozaki T, et al. Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis/dermatomyositis. Arthritis Rheum 2006 54 2004-2009. 

Horiki T, Ichikawa Y, Moriuchi J, et al. HLA class II haplotypes associated with pulmonary interstitial lesions of polymyositis/dermatomyositis in Japanese patients. Tissue Antigens 2002 59 25-30. 

Yamadori I, Fujita J, Kajitani H, et al. Lymphocyte subsets in lung tissues of interstitial pneumonia associated with untreated polymyositis/dermatomyositis. Rheumatol Int 2001 21 89-93. 

Miyazaki E, Ando M, Muramatsu T, et al. Early assessment of rapidly progressive interstitial pneumonia associated with amyopathic dermatomyositis. Clin Rheumatol 2007 26 436 39. 

Akira M, Hara H, Sakatani M. Interstitial lung disease in association with polymyositis-dermatomyositis long-term follow-up CT evaluation in seven patients. Radiology 1999 210 333-338. 

Takada K, Kishi J, Miyasaka N. Step-up versus primary intensive approach to the treatment of interstitial pneumonia associated with dermatomyositis/polymyositis a retrospective study. Mod Rheumatol 2007 17 123-130. 

---