Alpha-methyl-DOPA

Thyroid supplement Blood pressure medications Beta blockers Thiazide diuretics Alpha methyl DOPA Appetite suppressants Phentermine Sibutramine Other Alcohol Caffeine Cocaine Nicotine... 

P. Juvancz, The sleep of artificially reared newborn rats, effect of alpha-methyl-dopa treatment on paradoxical sleep and on adult behaviour, Acta Physiol. Acad. Sci. Hung., 57(1) (1981) 87-98. 

Carlsson A, Dahlstroem A, Fuxe K, Hillarp NA (1965) Failure of reserpine to deplete noradrenaline neurons of alpha-methylnoradrenaline formed from alpha-methyl dopa. Acta Pharmacol Toxicol (Copenh) 22 270-276. 

Harrison, W. H., Gray, R. H., and Solomon, L. M., Incorporation of L-dopa, L-alpha-methyl-dopa and DL-isoproterenol into guinea-pig hair, Acta Derm. Venereal, 54, 249, 1974. 

Acebutolol Alpha-methyl-dopa Captopril Carbimazole Chlorpromazine Dihydralazine Fludarabine Hydralazine Infliximab Interferons-alpha Iproniazid Isoniazid Nomifensine Penicillamine D-Penicillamine Practolol Procainamide Propylthiouracil rlL-2 Simvastatin Tienilic acid Tryptophan contaminants Zimeldine Lupus syndrome Autoimmune haemolytic anaemia Pemphigus ANCA-associated vasculitis Lupus syndrome Autoimmune hepatitis Autoimmune haemolytic anaemia Lupus syndrome, ANCA-associated vasculitis Lupus syndrome Wide range of autoimmune diseases Autoimmune hepatitis Lupus syndrome Autoimmune haemolytic anaemia Myasthenia, dermatomyositis Anti-GBM (Goodpasture) disease Oculocutaneomucous syndrome Lupus syndrome ANCA-associated vasculitis Autoimmune thyroiditis Lupus syndrome Autoimmune hepatitis Eosinophilia myalgia syndrome (see section 9.3.5) Guillain-Barre syndrome... 

Vertical dashed lines indicate blood pressure readings taken while patient was standing in erect position. Alpha-methyl-dopa did not control blood pressure in this patient, but did not produce postural hypotension seen with guanethidine... 

The higher narcotic potency in vivo of the S(-f )-isomer of hexobarbital was shown to be related to higher CNS levels than for the R( —) form, this seems to be due to an improved crossing of the blood-brain barrier (BBB). In a distribution study of (-1-)- and (— )-alpha-methyl-DOPA in the rat after intravenous injection, the (— )-isomer attained higher concentrations than the (-f)-form in most organs, in accordance with the fact that of the two isomers, only the (-) isomer has hypotensive activity. 

Alpha-methyl- DOPA (Aldomet) Decarboxylated to a-methyl dopamine then (3-hydroxylated to a-methyinorepinephrine, a potent a2 receptor agonist. Results in 4 mpathetic outflow from CNS. preganglionic sympathetic output, rapidly 4 blood pressure -but sympathetic system can respond with cardiac stimulation. Sedation, mild orthostatic hypotension, dry mouth, fever, nasal stuffiness, Coombs positive RBCs, salt and water retention, rebound hypertension. 

Mones RJ. Evaluation of alpha methyl dopa and alpha methyl dopa hydrazine with L-dopa therapy. N Y State JMed (1974) 74, 47-51. 

Lo Buglio AF, Jandl JH (1967) The nature of the alpha-methyl-dopa red-cell antibody. N Engl J Med 276 658... 

The rate of pregnancy-blocking is also reduced when the strange male belongs to an inbreeding strain or on administration of alpha-methyl dopa suggesting that dopaminergic nervous system are involved in the Bruce effect (338). 

Sahu, S.C., and C.J. Dominic Effect of alpha-Methyl Dopa Administration on the Pheromonal Block to Implantation in Mice. Curr. Sci. 52, 179-181 (1983). 

Fellinger, K., Grabner, G. and Krygicz, H., Voriaufiger Bericht iiber die klinische Wirksamkeit von /-Alpha-Methyl-Dopa (Aldomet) in der Behandlung der Hypertonie. Wien, Z. inn. Med. 42, 12, 527 (1961). 

The catecholamine-synthesizing enzymes are not only able to synthesize dopamine and norepinephrine from a physiologically occurring substrate such as L-dopa, but also from exogenous substrates such as alpha-methyldopa, which is converted to alpha-methyldopamine and in turn to alpha-methylnorepinephrine. Alpha-methyldopamine and alpha-methyl-norepinephrine are called false transmitters and, in general (except for alpha-methylnorepinephrine), are weaker agonists. Alpha-methyldopa is used in the management of hypertension. 

Methyldopa (l -pathway directly parallels the synthesis of norepinephrine from dopa illustrated in Figure 6-5. Alpha-methylnorepinephrine is stored in adrenergic nerve vesicles, where it stoichiometrically replaces norepinephrine, and is released by nerve stimulation to interact with postsynaptic adrenoceptors. Flowever, this replacement of norepinephrine by a false transmitter in peripheral neurons is not responsible for methyldopa s antihypertensive effect, because the a-methylnorepinephrine released is an effective agonist at the cx adrenoceptors that mediate peripheral sympathetic constriction of arterioles and venules. In fact, methyldopa s antihypertensive action appears to be due to stimulation of central a adrenoceptors by a-methylnorepinephrine or a-methyldopamine. 

---