Rodent model

To study the effect of an increased gene dosage of GR, Reichardt et al. (2000) and van den Brandt et al. (2007) generated rodent models of GR overexpression. These approaches confirmed that GR controls neuronal and immune functions in a dosage-dependent manner. These results highlight the importance of tight control of GR expression in target tissues and may explain... 

Fuxe K, Andersson K, Nilsen OG, et al Toluene and telencephalic dopamine selective reduction of amine mrnover in discrete DA nerve terminal systems of the anterior caudate nucleus by low concentrations of toluene. Toxicol Lett 12 115—123,1982 Cause EM, Mendez V, Geller I Exploratory smdies of a rodent model for inhalant abuse. Neurobehav Toxicol Teratol 7 143—148, 1985 Gentry JR, Hill C, Malcolm R New anticonvulsants a review of applications for the management of substance abuse disorders. Ann Clin Psychiatry 14 233—245, 2002 Gerasimov MR, Ferrieri RA, Schiffer WK, et al Smdy of brain uptake and biodistribution of [llCjtoluene in non-human primates and mice. Life Sci 70 2811 — 2828, 2002... 

Veronesi, B. (1992). Validation of a rodent model of OPfDN. In B. Ballantyne and T.C. Marrs, Clinical and Experimental Toxicology of Organophosphates and Carbamates, Oxford, U.K. Butterworth-Heinemann, 114—125. 

Keswani SC, Jack C et al (2006) Establishment of a rodent model of HIV-associated sensory neuropathy. J Neurosci 26(40) 10299-10304... 

Wallace VC, Blackbeard J et al (2007a) Pharmacological, behavioural and mechanistic analysis of HIV-1 gpl20 induced painful neuropathy. Pain 133(l-3) 47-63 Wallace VC, Blackbeard J et al (2007b) Characterization of rodent models of HIV-gpl20 and anti-retroviral-associated neuropathic pain. Brain 130(Pt 10) 2688-2702 Wechsler AF, Ho DD (1989) Bilateral Bell s palsy at the time of HIV seroconversion. Neurology 39(5) 747-748... 

Valentin G, Haas P, Gilmour D (2007) The chemokine SDFla coordinates tissue migration through the spatially restricted activation of Cxcr7 and Cxcr4b. Curr Biol 17 1026-1031 Wallace VC, Blackboard J, Segerdahl AR, Hasnie F, Pheby T, McMahon SB, Rice AS (2007) Characterization of rodent models of HlV-gpl20 and anti-retroviral-associated neuropathic pain. Brain 130(Pt 10) 2688-2702... 

Studies have demonstrated that treatment with soy or phytoestrogen enriched diets is effective in conserving bone in rodent models of osteoporosis (Anderson and Gamer, 1998 Ishimi et al, 2000 Draper et al, 1997). The mechanism of action of phytoestrogens on bone health is unclear but several mechanisms including inhibition of bone resorption and stimulation of bone formation maybe involved (Fanti etal, 1998 Ishimi e/a/., 1999 Picherit eta/., 2000). Limited data from studies in postmenopausal women have indicated that phytoestrogen supplements have a small, beneficial effect on bone loss in the lumbar spine (Alekel et al, 2000 Potter et al, 1998 Somekawa et al, 2001). 

The most convincing data have been obtained from rodent models of cancers that revealed protective effects of curcumin against cancers of aU sites. Curcumin is able to inhibit all steps of cancer processes, initiation, progression, and promotion. These observations, combined with the apparent lack of toxicity of curcumin for doses up to 8 g/day for 3 mo suggest potential uses of curcumin as an anti-carcinogenic chemoprotective agent. ... 

Bristol-Myers Squibb has recently disclosed two different series of carbamate-based FAAH inhibitors. The first of these is a series of 4,5-diaryl-imidazoles in which 30 compounds are specifically claimed, an example being compound (57). This compound is reported to have an IC50 value of < 10 nM. In addition, (57) was also active in vivo in rodent models of chemo-induced, thermal and neuropathic pain [72]. The second series of compounds is based on oxime carbamoyl FAAH inhibitors such as (58). Compound (58) is reported to have an IC50 value of < 10 nM and activity in rodent models of inflammatory pain, thermal pain and inflammatory oedema [73]. 

Taylor GN, Jones CW, Gardner PA, et al. 1981. Two new rodent models for actinide toxicity studies. Radiat Res 86 115-122. 

Many of the studies on the neurological effects of oral exposure to organophosphate ester hydraulic fluids in animals have employed chickens as models instead of the more commonly used rodent models. For reasons that are not well understood, organophosphate-induced delayed neuropathy can be induced in chickens and cats, but not in mice or rats (Abou-Donia and Lapadula 1990). 

Pawlyk, A. C., Jha, S. K., Brennan, F. X., Morrison, A. R. Ross, R. J. (2005). A rodent model of sleep disturbances in posttraumatic stress disorder the role of context after fear conditioning. Biol. Psychiatry 57, 268-77. 

Orexins in sleep and wakefulness rodent models of narcolepsy-cataplexy... 

Mieda, M. Yanagisawa, M. (2006). Rodent models of narcolepsy-cataplexy. In The Orexin/Hypocretin System Physiology and Pathophysiology, ed. S. Nishino T. Sakurai, Totowa, NJ Humana Press, pp. 255-66. 

Finkelman, F.D., Shea-Donohue, T., Goldhill, J., Sullivan, C.A., Morris, S.C., Madden, K.B., Cause, W.C. and Urban, J.F. (1997) Cytokine regulation of host defense against parasitic gastrointestinal helminths lessons from studies with rodent models. Annual Review of Immunology 15, 505-533. 

Fiorucci S, Distrutti E, Mencarelli A, Barban-ti M, Palazzini E, Morelli A Inhibition of intestinal bacterial translocation with rifaximin modulates lamina propria monocytic cells reactivity and protects against inflammation in a rodent model of colitis. Digestion 2002 66 246-256. 

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