Interferon signalling

Originally discovered as DNA-binding proteins that mediate interferon signaling, recent data demonstrated that STAT1 can also exert constitutive functions in the nucleus, which do not require STAT activation with tyrosine phosphorylation. Cells lacking STAT1 are... 

Dumoutier L, Tounsi A, Michiels T, Sommereyns C, Kotenko SV, Renauld JC (2004) Role of the interleukin (lL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of lL-29/interferon-lambda 1 similarities with type I interferon signaling. J Biol Chem 279 ... 

Takaoka A, Yanai H (2006) Interferon signalling network in innate defence. CeU Microbiol 8 ... 

Types I and type II Interferon Signaling IFNa/p IFNy... 

Vileek, J., Aguet, M., and Reis, L. F. L. (1998). In Cytokine Knockouts (ed S. K. Durum and K. Muegge), Knockouts of interferons, interferon receptors and interferon signaling components, pp. 207-225. Humana Press, Totowa, NJ. 

There may be a host of secondary transcriptional regulators, such as the IltPs, the interferon regulatory factors that could specify interferon signalling. 

HGPRT cells + reporter gene) defective for interferon signaling... 

Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 267 1347-1349. 

GH stimulation. This led to the discovery that an intracellular signaling protein and transcription factor, termed STAT5b, is present in its nuclear, tyrosine phosphorylated form at a substantially higher level in male rat liver than in female rat liver 3, STATs are latent cytoplasmic transcription factors that are activated by tyrosine phosphorylation induced by a variety of cytokines and growth factors, and were first discovered as signal mediators that carry transcription signals into the nucleus in the interferon signaling pathway ". ... 

Darnell JE Jr, Kerr IM, Stark GR (1994) Jak-Stat pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264 1415-1421 David M (1995) Transcription factors in interferon signaling. Pharmacol Ther 65 149-161 Davignon J-L, Castanie P, Yorke JA, Gautier N, Clement D, Davrinche C (1996) Anti-human cytomegalovirus activity of cytokines produced by CD4+ T-cell clones specifically activated by lEl peptides in vitro. J Virol 70 2162-2169 Doherty P (1995) Immunity to viruses. The Immunologist 3 231-233... 

Leonard GT, Sen GC (1996) Effects of adenovirus El A protein on interferon-signaling. Virology 224 25-33... 

Wang S-Z, Roberts RM. The evolution of the gene product, a htde known protein implicated in stress responses and type I interferon signaling in vertebrates. BMC Evol Biol. 2005 v.5. doi 10.1186/1471-2148-5-13. 

Rachmilewitz, D Raz, E. Katakura, K. Lee, J. Methods using agents that increase the level of a Type I interferon and/or activate a Type I interferon signaling pathway for treating gastrointestinal inflammation. PCX Int. Appl. WO 2006091591, 2006 Chem. Abstr. 2006,145, 285155. 

Dermatomyositis occurred in a 57-year-old patient who took interferon beta for multiple sclerosis [56 ]. Immunohistochemical staining of skin biopsies for myxovirus-resistance protein A (a surrogate marker of cutaneous type I interferon signalling) showed increased staining that correlated temporally with interferon beta treatment and subsequent disease activity. In vitro treatment with interferon beta of peripheral blood mononuclear cells isolated from this patient showed enhanced type I interferon signaling, assessed by interferon-induced gene expression profiles. 

Somani A-K, Swick AR, Cooper KD, McCormick TS. Severe dermatomyositis triggered by interferon beta-la therapy and associated with enhanced type i interferon signaling. Arch Dermatol 2008 144 (10) 1341-9. 

Retinoids and interferon signalling pathways and their cross-talk... 

Cross-talk between retinoid and interferon signalling pathways... 

Leung S, Qureshi SA, Kerr IM, Darnell JE, Stark GR (1995) Role of STAT2 in the a interferon signalling... 

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