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Signal-recognition particle

The signal recognition particle (SRP) is a cytosolic ribonucleoprotein complex which binds to signal sequences of nascent membrane and secretory proteins emerging from ribosomes. The SRP consists of a 7S RNA and at least six polypeptide subunits (relative molecular masses 9, 14, 19, 54, 68, and 72 kD). It induces an elongation arrest until the nascent chain/ ribosome/SRP complex reaches the translocon at the endoplasmic reticulum (ER) membrane. [Pg.1132]

Krieg, U.C., Walter, P., and Johnson, A.E. (1986) Photocross-linking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle. Proc. Natl. Acad. Sci. USA 83, 8604-8608. [Pg.1085]

Subunits of signal recognition particles and their receptors... [Pg.63]

Matoba, S., and Ogrydziak, D. (1998). Another factor besides hydrophobicity can affect signal peptide interaction with signal recognition particle. J. Biol. Chem. 273, 18841—... [Pg.337]

Qi, H.-Y., and Bernstein, H. (1999). SecAis required for the insertion of inner membrane proteins targeted by the Eschericha coli signal recognition particle. J. Biol. Chem. 274, 8993-8997. [Pg.340]

Plumper E, Bradley PJ, Johnson PJ (2000) Competition and protease sensitivity assays provide evidence for the existence of a hydrogenosomal protein import machinery in Trichomonas vaginalis. Mol Biochem Parasitol 106 11-20 Pool MR (2005) Signal recognition particles in chloroplasts, bacteria, yeast and mammals (review). Mol Membr Biol 22 3-15... [Pg.70]

In eukaryotic cells, one class of signal sequences is recognized by the signal recognition particle (SRP), which binds the signal sequence as soon as it appears on the ribosome and transfers the entire ribosome and incomplete polypeptide to the ER. Polypeptides with these signal sequences are moved into the ER lumen as they are synthesized once in the lumen they may be modified and moved to the Golgi complex, then sorted and sent to lysosomes, the plasma membrane, or transport vesicles. [Pg.1077]

Sickle cell disease 16, 359, 360 Side chains packing 75 Siderophilins 840 Siderophore(s) 838, 838s chelate effect 310 receptors 839 Sieve plates 30 Signal peptidase 522, 620 Signal recognition particle (SRP) 520 Signal sequences 519 Signaling 1... [Pg.933]

The Alu sequence has strong homology with the 7S RNA (Table 5-4) that is part of the signal recognition particle involved in transport of newly synthesized peptide chains across the membranes of the ER (Chapter 10). Alu sequences are transcribed into hnRNA, the precursors to mRNA. Some Alu sequences are present in intervening sequences (introns)... [Pg.1538]

How are the possible choices for newly formed proteins made Much seems to depend upon the amino acid sequences at the ends of the polypeptide chains. As they emerge from a ribosome, some N-terminal signal sequences bind to recognition proteins. One such protein labels the ends of proteins destined for secretion into the vesicles of the ER. This protein ensures that the protein end binds to the signal recognition particle (SRP), enters a translocon pore, and undergoes cotranslational passage into the periplasmic space in bacteria or the ER in eukaryotes. Cotranslational modification reactions also occur both in the... [Pg.1721]

Shine-Dalgamo sequence Signal recognition particle proteasome... [Pg.1739]

Siegel, V., and P. Walter, Each of the activities of signal recognition particle (SRP) is contained within a distinct domain. Cell 52 39-49, 1988. [Pg.766]

NMR nuclear magnetic resonance SRP signal recognition particle... [Pg.868]

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Signal recognition particle RNA

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