Bone marrow—derived stem cells

Tao, H. and Ma, D. D. Evidence for transdifferentiation of human bone marrow-derived stem cells recent progress and controversies. Pathology 35 6-13,2003. 

In the attempt to explain the events observed, it was supposed that the reason for above has been the exhaustion of proliferative potential of hemopoietic stem cells, so called the Hayflick s limit, observed previously for the cells, proliferating in vitro (Hayflick and Moorhead, 1961 Hayflick, 1965). However, approximately at the same time it was shown, that due to successive transfers of bone marrow stem cells to lethally irradiated young recipients (mice) the proper life span of bone marrow derived stem cells exceeds at least 3 to 4 times the maximal life span of their hosts. It seems that extinction of these... 

Grove J. E., Bruscia E., Krause D. S. (2004). Plasticity of bone marrow-derived stem cells, Stem Cells, 22, 487-500. 

Krause, D.S., Theise, N.D., Collector, M.I., et al (2001) Multi organ, multi lineage engraftment by a single bone marrow-derived stem cell. Cell 105, 369 377. 

Stem Cell Types and Characteristics Adult Bone Marrow-Derived Stem Cells... 

Adult bone marrow-derived stem cells are presently the cell types most widely utilized in cardiac stem cell therapy. A heterogeneous subset, termed autologous bone marrow-derived mononuclear cells (ABMMNCs), is composed of small amounts of stromal or MSCs, HPCs, EPCs, and more committed cell lineages, such as natural killer lymphocytes, T lymphocytes, B lymphocytes, and others [2]. 

Clinical research with bone marrow-derived stem cells has focused on the period immediately after an AMI and on the chronic phase of ischemic heart disease. In these clinical scenarios, therapy has been targeted to viable myocardium with or without systolic heart failure. On the other hand, skeletal myoblast therapy has been used to treat ischemic heart failure involving nonviable myocardium or scar... 

For angiogenesis and vasculogenesis, the following cells can be proposed ECs, bone marrow-derived stem cells, and circulating blood-derived progenitor cells, For myogenesis, skeletal myoblasts, smooth muscle cells, or fetal and neonatal cardiomyocytes can be used, The relative contribution of various sources of precursor cells in postnatal muscles and the factors that may enhance stem cell participation in the formation of new skeletal and cardiac muscle in vivo have... 

Experimental studies comparing different cell types in cellular cardiomyoplasty. Skeletal myoblasts have a higher myogenic potential, whereas bone marrow-derived stem cells seem to be more capable of inducing angiogenesis. Several cell types lead to functional improvement. One study suggests synergistic effects of different cell types in combined treatment. 

Comparison of clinical studies using bone marrow and blood-derived cells after acute myocordian infarction to prevent the development of heart failure. Currently, bone marrow-derived stem cells show greater potential to treat early-stage disease, primarily owing to their angiogenic potential, leading to improved left ventricle protection and ultimately to better preserved function. 

Janssens SDC, Bogaert J, Theunissen K, et al. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction double-blind, randomised controlled trial. Lancet 2006 367 1 13-121. 

Recently, it has been suggested that adult bone marrow-derived stem cells can cross boundaries and give rise to a broader... 

Gailicchio, V. S Casale, G. R, and Watts, T, (1987b). Inhibition of human bone marrow-derived stem cell colony formation (CFU-E, BFU-E, and CFU-GM) following in vitro exposure to organophosphaies. FLxp. Hematol. 15, 1099-1102. 

Multipotent Adult Progenitor Cells (MAPCs) MAPCs are bone marrow-derived stem cells with an extensive in vitro expansion ability, more than 80 population doublings, as well as a capacity to differentiate in vivo and in vitro into tissue cells of all three germinal layers ectoderm, mesoderm, and endoderm. These cells have been isolated from three different species, including mouse, rat, and human [27]. 

Khang, G., Shimizu, T . Manuals for Differentiation of Bone Marrow-Derived Stem Cell to Specific Cell Types. World Scientific, Singapore (2014)... 

Kogler G et al (2004) A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med 200 123 135 Kopen GC et al (1999) Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA 96 10711-10716 Kops GJ et al (1999) Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398 630-634 Krause DS et al (2001) Multi-organ, multi-lineage engraft-ment by a single bone marrow-derived stem cell. Cell 105 369-377... 

Figure 6.8 Representative silk fibroin 3D structures of (a) square lattice and (b) circular web (c) magnified image of direct write silk fiber, (d) 3D silk scaffold cultured with human bone marrow derived stem cells in...

Tumorigenicity In a case report, donor bone marrow-derived stem cells produced an oral squamous cell carcinoma composed of donor cells 2 years after transplant [178 ]. 

Hu YX, Luo Y, Tan YM, Shi JM, Sheng LX, Fu HR, et al. Donor bone marrow-derived stem cells contribute to oral squamous ceU carcinoma transformation in a recipient after hematopoietic stem ceU transplantation. Stem Cells Dev January 20, 2012 21(2) 177-80. http //dx.doi. org/10.1089/scd.2011.0308. Epub 2011 Oct 18. 

Juopperi, T. A., Schuler, W., Yuan, X. et al. 2007. Isolation of bone marrow-derived stem cells using density-gradient separation. Exp Hematol. 35 335-41. 

Baffour, R., Pakala, R., HeUinga, D. et al. 2006. Bone marrow-derived stem cell interactions with adult cardiomyocytes and skeletal myoblasts in vitro. Cardiovasc Revasc Med 7(4) 222-30. 

Dreyfus, P.A., Chretien, R, Chazaud, B. et al. 2004. Adult bone marrow-derived stem cells in muscle connective tissue and satellite cell niches. Am JPathol 164(3) 773-79. 

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