Cellular cardiomyoplasty

Gold HK, Vacant JP, Oesterle SN. Percutaneous transvenous cellular cardiomyoplasty. A novel nonsurgical approach for myocardial cell transplantation. J Am Coll Card/o/2003 41 1964-1971. 

Chachques JC, Herreros J, Trainini J, Juffe A, Rendal E, Prosper F, Genovese J. Autologous human serum for cell culture avoids the implantation of cardioverter-defibrillators in cellular cardiomyoplasty. Int J Cardiol 2004 95 Suppl LS29-33. 

Chachques JC, Shafy A, Duarte F et al. From dynamic to cellular cardiomyoplasty. J Cardiac Surg 2002 17 194-200. 

In summary, this is a dynamic time in a new field treatment strategies are being developed and modified almost daily new cell types are being reported novel delivery strategies are emerging and slowly, we are dissecting the components of cellular cardiomyoplasty. 

Experimental studies comparing different cell types in cellular cardiomyoplasty. Skeletal myoblasts have a higher myogenic potential, whereas bone marrow-derived stem cells seem to be more capable of inducing angiogenesis. Several cell types lead to functional improvement. One study suggests synergistic effects of different cell types in combined treatment. 

Although a few direct clinical comparisons have been made, several recent preclinical studies have been performed to compare the beneficial effects of different cell types for cellular cardiomyoplasty (Table I). According to these, skeletal muscle-derived cell transplantation may be more effective than the transplantation of adult cardiomyocytes, dermal or cardiac fibroblasts, or BM-MNC in the subacute or chronic Ml setting (27-29). This could reflect the greater survival of myoblasts than of cardiocytes and/or an active impact of myoblasts on cardiac systolic function as compared with a... 

Chiu RC, Zibaitis A, Kao RL. Cellular cardiomyoplasty myocardial regeneration with satellite cell implantation. Ann Thorac Surg 1995 60 12-18. 

Hutcheson KA, Atkins BZ, Hueman MT, Hopkins MB, Glower DD, Taylor DA. Comparison of benefits on myocardial performance of cellular cardiomyoplasty with skeletal myoblasts and fibroblasts. Cell Transpl 2000 9 359-368. 

Thompson CA. Transvascular cellular cardiomyoplasty. Int J Cardiol 2004 95(suppl l) S47-49. 

Chachques JC, Acar C, Herreros J, et al. Cellular cardiomyoplasty clinical application. Ann Thorac Surg 2004 77(3) I 121-1 130. 

Guhathakurta, S., Subramanyan, U. R., Balasundari, R., Das, C. K., Madhusankar, N., and Cherian, K. M. 2009. Stem cell experiments and initial clinical trial of cellular cardiomyoplasty. Asian Cardiovasc ThoracAnn, 17, 581-6. 

Wang, F. and Guan, J. 2010a. Cellular cardiomyoplasty and cardiac tissue engineering for myocardial therapy. Adv Drug Deliv Rev 62 784-97. 

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