Lineage-committed cells

Chen S, et al. Dedifferentiation of lineage-committed cells by a small molecule. I. Am. Chem. Soc. 2004 126 410 11. 

Szabo SJ, Kim ST, Costa GL, et al. A novel transcription factor, T-bet, directs Thl lineage commitment. Cell. 2000 100 655-669. 

McBeath R, Pirone DM, Nelson CM, Bhadriraju K, Chen CS (2004) Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 6 483-95... 

Gross, R. E., Mehler, M. F., Mabie, P. C., Santschi, L., Ngo, P. and Kessler, J. A. Promotion of astroglial lineage commitment from mammalian subventricular zone progenitor cells by bone morphogenetic proteins. Neuron 17 1-20,1996. 

M. A. Cross and T. Enver, The lineage commitment of haemopoietic progenitor cells, Current Opinionin Genetics and Development , 609-613 (1997). 

Adult bone marrow-derived stem cells are presently the cell types most widely utilized in cardiac stem cell therapy. A heterogeneous subset, termed autologous bone marrow-derived mononuclear cells (ABMMNCs), is composed of small amounts of stromal or MSCs, HPCs, EPCs, and more committed cell lineages, such as natural killer lymphocytes, T lymphocytes, B lymphocytes, and others [2]. 

Metcalf, D., Lineage commitment and maturation in hematopoietic cells the case for extrinsic regulation. Blood, 1998. 92(2) 345-7 discussion 352. 

Interest in stem cells has heightened because of recent improvements in methods for propagation of human cells in culture and their promise for regenerative medicine. Cell culture techniques are pivotal for expansion of the limited numbers of cells present in vivo and in inducing lineage commitment of progeny cells. 

Chen S, Takanashi S, Zhang Q, Xiong W, Zhu S, Peters EC, Ding S, Schultz PG. Reversine increases the plasticity of lineage-committed mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 2007 104 10482-10487. 

To identify small molecules that induce reprogramming of lineage-committed myoblasts, a cell-based screen was designed based on the notion that lineage-reversed myoblasts would regain multipotency. Specihcally, dedifferentiated myoblasts... 

Metcalf D. (1991). Lineage commitment of hemopoietic progenitor cells in developing blast cell colonies influence of colony-stimulating factors. Proc Nat Acad Sci USA, 88, 1310-1314. 

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