Angiogenic potential

The corneal pocket assay and the window preparations are designed to measure vessel formation after addition of stimulators. These assays can for instance be used for the study of angiogenic potential of human tumours. These models are also suitable for pre-clinical testing of angiogenesis inhibitors. 

Comparison of clinical studies using bone marrow and blood-derived cells after acute myocordian infarction to prevent the development of heart failure. Currently, bone marrow-derived stem cells show greater potential to treat early-stage disease, primarily owing to their angiogenic potential, leading to improved left ventricle protection and ultimately to better preserved function. 

In acute or chronic ischemia patients, angiogenic potential of transplanted cells is of the greatest importance. The patients with chronic nonviable scar and myocardial dysfunction are more likely to benefit from the cells that, either directly or indirectly (via paracrine effect) (47), improve the contractility of the treated myocardium (9). Autologous skeletal myoblasts have been successfully expanded in vitro and implanted in the myocardia of animals. Although they do not contract synchronously with the rest of the myocardium and do not integrate into it, they have been shown to improve contractility... 

Procedure. The assay was originally described by Passaniti (Pas-saniti et al., 1992) who studied the angiogenesis induced by bFGF and heparin. This method has been extensively used to study the angiogenic potential of Kaposi s Sarcoma cell (KS) supernatants and HIV Tat protein (Albini et al., 1994) and to test numerous an-tiangiogenic compounds (TIMP-2, IFNs, Somatostatin. ..) (Albini et al., 1994, 1999 Benelli et al., 1997 lurlaro et al., 1998). 

Albini, A., Fontanini, G., Masiello, L., Tacchetti, C., Bigini, D., Luzzi, P., Noonan, D. M. and Stetler-Stevenson, W, G. (1994). Angiogenic potential in vivo by Kaposi sarcoma cell-free supernatants and HIVl-tat product inhibition of KS-like lesions by TlMP-2. AIDS 8,1237-1244. 

Xiong, H.Q., J.L. Abbruzzese, E. Lin, L. Wang, L. Zheng, and K. Xie. NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells. Int J Cancer 108 181-8, 2004. 

K. W. Kim, W.B. Kim, S. Hong, Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials, Biochem. Biophys. Res. Commun. 2004, 315, 964-970. 

Albini A, Fontanini G, Masiello L, Tacchetti C, Bigini D, Luzzi P, Noonan DM, Stetler-Stevenson WG Angiogenic potential in vivo by Kaposi s sarcoma cell-free supernatants and HIV-1 tat product Inhibition of KS-like lesions by tissue inhibitor of metalloproteinase-2. Aids 1994 8 1237-1244. 

Jiang, C., Agarwal, R., and Lu, J., Anti-angiogenic potential of a cancer chemopreventive flavonoid antioxidant, silymarin inhibition of key attributes of vascular endothelial cells and angiogenic cytokine secretion by cancer epithelial cells. Biochemical Biophysical Rese. Commun., 276, 371-378, 2000. 

Miyazawa, T. et al.. Anti-angiogenic potential of tocotrienol in vitro. Biochemistry (Moscow), 69 (1), 67-69,2004. 

Fernandez A, Udagawa T, Schwesinger C, Beecken W, Achilles-Gerte E, McDonnell T, D Amato R. Angiogenic potential of prostate carcinoma cells overexpressing bcl-2. JNatl Cancer Inst 2001 93 208-213. 

Urokinase plasminogen Decrease angiogenic potential MDA-MB-231 cell line ZR-75-1 cell line 136... 

Members of the CXC chemokine family play disparate roles in the regulation of angiogenesis (an overview of chemokines is provided in Chap. 1). CXC chemokines are characteristically heparin-binding proteins. On a structural level, they have four highly conserved cysteine amino acid residues, the first two cysteines separated by one nonconserved amino acid residue—hence the name CXC (45-57). Although the CXC motif distinguishes this family from other chemokine families, a second structural domain within this family dictates their angiogenic potential. The NH2 terminus of the majority of the CXC chemokines contains three amino acid residues (Glu-Leu-Arg the ELR motif), which precedes the... 

Panneerselvan A, Nguyen LTH, Su Y, Eong Teo W, Liao S, Ramakrishna S, et al. Cell viability and angiogenic potential of a bioartificial adipose substitute. J Tissue Eng Regen Med June 2015 9(6) 702-13. 

Santos, M.I., Tuzlakoglu, K., Fuchs, S., Gomes, M.E., Peters, K., Unger, R.E., Piskin, E., Reis, R.L., Kirkpatrick, C.J., 2008. Endothelial cell colonization and angiogenic potential of combined nano- and micro-fibrous scaffolds for bone tissue engineering. Biomateiials 29, 4306-4313. 

Santos, M. 1., etai.. Endothelial Cell Colonization and Angiogenic Potential of Combined Nano-and Micro-fibrous Scaffolds for Bone Tissue engineering. Biomaterials, 2008,29(32), 4306-4313. 

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