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Cardiac stem cells

Adult tissue-specific stem cells are present in other self-renewable organs, including the liver, pancreas, skeletal muscle, and skin. The heart, which until very recently was considered a terminally differentiated, postmitotic organ with a finite store of myocytes established at birth, may now be added to this list. It has recently been observed that hematopoietic stem cells (HSCs) can transdifferentiate into car-diomyocytes [33, 34] and that stem cells reside in the heart [35]. These resident cardiac stem cells (CSCs)... [Pg.95]

Adult bone marrow-derived stem cells are presently the cell types most widely utilized in cardiac stem cell therapy. A heterogeneous subset, termed autologous bone marrow-derived mononuclear cells (ABMMNCs), is composed of small amounts of stromal or MSCs, HPCs, EPCs, and more committed cell lineages, such as natural killer lymphocytes, T lymphocytes, B lymphocytes, and others [2]. [Pg.97]

Clinical Trials of Cardiac Stem Cell Therapy... [Pg.112]

With regard to left ventricular function, cardiac stem cell therapy is well tolerated overall. No proar-rhythmic effects have been observed to date with ABMMNC therapy, although other deleterious effects are possible. Early concerns about abnormal transdifferentiation and tumorigenesis have subsided, but the potential for accelerated atherogen-esis remains, given the limited clinical experience... [Pg.121]

Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara FI, Rota M, Musso E, Urbanek K, Leri A, Kajstura J, Nadal-Ginard D, Anversa P. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003 114 763-776. [Pg.123]

Urbanek K, Quaini F, Tasca G, Torella D, Castaldo C, Nadal-Ginard D, Leri A, Kajstura J, Quaini E, Anversa P. Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci USA 2003 100 10440-10445. [Pg.123]

Messina E, De Angelis L, Frati G, Morrone S, Chimenti S, Fiordaliso F, Salio M, Battaglia M, Latronico MV, Coletta M, Vivarelli E, Frati L, Cossu G, Giacomello A. Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res 2004 95 911-921. [Pg.124]

Piero Anversa, Jan Kajstura, Annarosa Leri, Roberto Bolh. Life and death of cardiac stem cells a paradigm shift in cardiac biology. Circulation 2006 113 1451-1463. [Pg.128]

Beltrami AR Barlucchi L, Torella D, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration, Cell 2003 I I4(6) 763 776. [Pg.448]

Saha, M., and Ferro, A. 2006. Cardiac stem cell therapy present and future. Br. J. Clin. Pharmacol. [Pg.264]

It is now suggested that the adult heart may not be a terminally differentiated organ because it contains stem cells supporting its regeneration. Adult cardiac stem cells are multipotent, giving rise to endothelial cells, smooth muscle cells and functional cardiomyocytes. The existence of these cells opens new opportunities for myocardial repair.259 See chapter 6. [Pg.64]

A.P. Beltrami, L. Barlucchi, D. Torella, M. Baker, F. Limana, S. Chimenti, H. Kasahara, M. Rota, E. Musso, K. Urbanek, A. Leri, J. Kajstura, B. Nadal-Ginard and P. Anversa, Adult cardiac stem cells are multipotent and support myocardial regeneration, Cell 114(6), 763-776 (2003). [Pg.76]

Guo et al. designed a novel self-assembling peptide (RGDSP) nanofiber as cell carrier to deliver BM-derived cardiac stem cells (CSCs) to repair infarct myocardium [146]. In vitro studies showed that the RGDSP scaffolds supported... [Pg.42]

D Amario D, Cabral-Da-Silva MC, Zheng H, Fiorini C, Goichberg P, Steadman E, Feneira-Martins J, Sanada F, Piccoli M, Cappetta D, D Alessandro DA, Michler RE, Hosoda T, Anastasia L, Rota M, Leri A, Anversa P, Kajstura J. Insulin-like growth factm-l tecepUn- identifies a pool of human cardiac stem cells with superior therapeutic potential for myocardial regeneration. Circ Res. 2011 108 1467-81. [Pg.681]

Since the initial public discussion of CiPA in July 2013, there has been a concerted international effort to define, standardize, and validate the human ion channel assays, define the metrics of the in sUico model, test and validate [human cardiac stem cell-derived cardiomyocyte-based] approaches, and define and test Phase 1 ECO biomarkers. Significant sdentific progress has been made and the CiPA effort is on track to complete the necessary work by the end of 2017. The CiPA Steering Committee is providing the ICH S7B/E14... [Pg.331]

The second approach involves the injection of isolated exogenous cells. For example, pluripotent stem cells have been injected into the circulatory system or directly into the heart. Furthermore, embryonic stem cells, skeletal myoblasts, skeletal muscle-derived multimyogenic stem cells, unselected bone marrow stem ceUs, mesenchymal stem cells, endothelial precursor cells, " and adult cardiac stem cells have been shown to differentiate into cardiac phenotypes. Though improved cardiac function has been reported, the underlying mechanism is not clear and the survival rates of the cells tend to be extremely low. This is probably due to the lack of local support for the cells to grow and establish themselves. [Pg.3448]

H.-D. Guo, H.-J. Wang, Y.-Z. Tan, J.-H. Wu, Transplantation of marrow-derived cardiac stem cells carried in fibrin improves cardiac function after myocardial infarction. Tissue Eng. Part A 17 (2011) 45-58, http //dx.doi.org/10.1089/ten.TEA.2010.0124. [Pg.461]

Gurusamy, N., Ray, D., Lekli, 1., and Das, D.K. 2010. Red wine antioxidant resveratrol-modified cardiac stem cells regenerate infarcted myocardium. J CellMolMed. 74 2235-9. [Pg.517]

G. Roberto, L. Mario, B. Lucio, et al., Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields, Cardiovascular Research 2009, vol. 82, pp. 411-420. [Pg.809]

Human cardiac stem cells. Proc. Natl. Acad. Sci. U.S.A., 104,14068-14073. [Pg.697]

Torella, D., Ellison, G. M., Mendez-Ferrer, S., Ibanez, B., and Nadal-Ginard, B. 2006. Resident human cardiac stem cells Role in cardiac cellular homeostasis and potential for myocardial regeneration. Nat. Clin. Pract. Cardiovasc. Med., 3(Suppl 1), S8-S13. [Pg.702]

Garbern JC, Lee RT (2013) Cardiac stem cell therapy and the promise of heart regeneration. CeU Stem Cell 12 689-698... [Pg.60]


See other pages where Cardiac stem cells is mentioned: [Pg.103]    [Pg.112]    [Pg.124]    [Pg.66]    [Pg.148]    [Pg.44]    [Pg.151]    [Pg.1751]    [Pg.157]    [Pg.365]    [Pg.684]    [Pg.684]    [Pg.292]   
See also in sourсe #XX -- [ Pg.44 ]




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