Multipotent adult progenitor cell

Hsieh, J., Aimone, J. B., Kaspar, B. K., Kuwabara, T., Nakashima, K. and Gage, F. H. IGF-I instructs multipotent adult progenitor cells to become oligodendrocytes. J. Cell Biol. 164 111-122, 2004. 

The ability of adult stem cells to become something other than what they were destined to be is controversial. One team of scientists has reported that a particularly promising adult stem cell, isolated from bone marrow and called a multipotent adult progenitor cell (MAPC), appears able to develop into many different kinds of specialized cells in the laboratory. Other scientists have not been able to reproduce these results. Additionally, scientists have reported that stem cells found in fat can become muscle cells, nerve cells, or even pancreas cells able to make insulin, under the right laboratory conditions. 

Multipotent adult progenitor cell (MAPC)—Unspecialized cell found... 

Multipotent adult progenitor cells (MAPCs) isolated by fluorescent-activated cell sorting (FACS) from the bone marrow... 

Plasticity of HSCs. The hematopoietic tissues such as the bone marrow and peripheral blood have heterogeneous stem cell populations, including hematopoietic stem cells, mesenchymal stem cells, multipotent adult progenitor cells, and endothelial precursor cells. HSCs have been widely used to study the plasticity of adult stem cells [23]. Stem cell plasticity can be defined as a unique property of tissue-specific adult stem cells. Approximately more than 80% of studies reporting... 

Multipotent Adult Progenitor Cells (MAPCs) MAPCs are bone marrow-derived stem cells with an extensive in vitro expansion ability, more than 80 population doublings, as well as a capacity to differentiate in vivo and in vitro into tissue cells of all three germinal layers ectoderm, mesoderm, and endoderm. These cells have been isolated from three different species, including mouse, rat, and human [27]. 

Schwartz R E, Reyes M, Koodie L, et al. (2002). Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J. Clin. Invest. 109 1291-1302. 

Reyes M, Verfaillie C M (2001). Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells. Ann. NY Acad. Sci. 938 231-233, discussion 233-235. 

Keene C D, Ortiz-Gonzalez X R, Jiang Y (2003). Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos. Cell Transplant. 12 201-213. 

Jiang Y, Henderson D, Blackstad M, et al. (2003). Neuroectodermal differentiation from mouse multipotent adult progenitor cells. Proc. Natl. Acad. Sci. USA. 100(suppl 1) 11854-11860. 

Gevaert, K. Pinxteren, J. Demol, H. HugeHer, K. Staes, A. Van Damme, J. Martens, L. Vandekerckhove, J. Four stage liquid chromatographic selection of methionyl peptides for peptide-centric proteome analysis the proteome of human multipotent adult progenitor cells. J. Proteome Res. 2006, 5, 1415-1428. 

Ross, J.J. et aL, Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells./. Clin. Invest, 2006.116(12) 3139-49. 

Synthesis Synthetic methods Staining Applications Bacteria human adipose-derived stem cells multipotent adult progenitor cells parasite lips skin hairs keratin fibers ... 

Price, E. M. Prather, R. S. Foley, C. Multipotent adult progenitor cell lines originating from the peripheral blood of green fluorescent protein transgenic swine. Stem Cells Dev. 2006,15,507-522. 

Busch, S. A., Hamilton, J. A., Horn, K. R, Cuascut, E X., Cutrone, R., Lehman, N., Deans, R. J., Ting, A. E., Mays, R. W., and Silver, J. 2011. Multipotent adult progenitor cells prevent macrophage-mediated axonal dieback and promote regrowth after spinal cord injury. Journal of Neuroscience, 31 944-53. 

---