Marrow stromal cells

EDI), and water to produce a group of biodegradable PU foams. The interconnected pores varied in size from 10 to 2 mm in diameter. Rabbit bone-marrow stromal cells cultured on the materials for up to 30 days formed multilayers of confluent cells and were phenotypically similar to those grown on tissue culture PS. It supported the adherence and proliferation of both bone-marrow stromal cells and chondrocytes in vitro. In subdermal implants the investigators found that the material showed infiltration of both vascular cells and connective tissue. 

Birnbaum T, Roider J, Schankin CJ, Padovan CS, Schichor C, Goldbrunner R, Straube A (2007) Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines. J Neurooncol 83 241-247... 

Lee RH, Hsu SC, Munoz J et al (2006) A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice. Blood 107 2153-2161... 

Van Den Heuvel R, Schoeters G, Vanderborght O. 1987. Radiosensitivity to 241 Am of bone marrow stromal cells in offspring of contaminated mice. In Age-related factors in radionuclide metabolism and dosimetry. Netherlands Kluwer Academic Publishers, 201-208. 

The murine stromal-derived factor-la (SDF-1)/CXCL12 was originally cloned from a cDNA library derived from the bone marrow stromal cell tine ST2 by a method to clone cDNAs that carry specific amino terminal signal sequences, such as those encoding intercellular signaling-transducing molecules... 

Cherry, Yasumizu R, Toki J, et al. Production of hematopoietic stem cell-chemotactic factor by bone marrow stromal cells. Blood 1994 83(4) 964-971. 

Simmons PJ, Masinovsky B, Longenecker BM, Berenson R, Torok-Storb B, Gallatin WM. Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells. Blood 1992 80(2) 388—395. 

Oba Y, Lee JW, Ehrlich LA, et al. MIP-lalpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells. Exp Hematol 2005 33(3) 272-278. 

Vande Broek I, Asosingh K, Vanderkerken K, et al. Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2, and -3. Br J Cancer 2003 88 855-862. 

Silk fibers or monolayers of silk proteins have a number of potential biomedical applications. Biocompatibility tests have been carried out with scaffolds of fibers or solubilized silk proteins from the silkworm Bombyx mori (for review see Ref. [38]). Some biocompatibility problems have been reported, but this was probably due to contamination with residual sericin. More recent studies with well-defined silkworm silk fibers and films suggest that the core fibroin fibers show in vivo and in vivo biocompatibility that is comparable to other biomaterials, such as polyactic acid and collagen. Altmann et al. [39] showed that a silk-fiber matrix obtained from properly processed natural silkworm fibers is a suitable material for the attachment, expansion and differentiation of adult human progenitor bone marrow stromal cells. Also, the direct inflammatory potential of silkworm silk was studied using an in vitro system [40]. The authors claimed that their silk fibers were mostly immunologically inert in short and long term culture with murine macrophage cells. 

Main producer cells Bone marrow stromal cell Macrophages Fibroblasts Lymphocytes Myoblasts Osteoblasts Monocytes Fibroblasts Endothelial cells Macrophages T-lymphocytes Fibroblasts Endothelial cells... 

Kopen, G. C., Prockop, D. J. and Phinney, D. G. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc. Natl Acad. Sci. U.S.A. 96 10711-10716,1999. 

Yamaguchi, K., et. al., Activation of the aryl hydrocarbon receptor/transcription factor and bone marrow stromal cell-dependent pre-B cell apoptosis, J. Immunol., 158, 2165,1997. 

Lavin, A., Hahn, D., and Gasiewicz, T. A., Expression of functional aromatic hydrocarbon receptor and aromatic hydrocarbon nuclear translocator proteins in murine bone marrow stromal cells, Arch. Biochem. Biophys., 352, 9, 1998. 

In vitro cellular MRI was also recently conducted with Gd C60[C(COOH)2]10 (Sitharaman et al., 2007). In this study, marrow stromal cells (MSC) and NIH 3T3 stem cells were efficiently labeled with the polycarboxylated gadofullerene and... 

Dorshkind K, 1990. Regulation of hemopoiesis by bone marrow stromal cells and their products. Ann Rev Immnnol 8 111... 

CSF-1 is synthesized by many different cell types including fibroblasts, endothelial cells, bone marrow stromal cells, osteoblasts, keratinocytes, astrocytes, myoblasts and, during pregnancy, under the control of estrogen and progesterone, by uterine epithelial cells. Circulating CSF-1 (ti/2 = 10 min) is synthesized by endothelial cells and smooth muscle cells. It is primarily cleared by CSF-lR-mediated internalization and destruction by Kupffer cells. Thus the number of sinusoidally located macrophages actually determines the concentration of the cytokine... 

Beresford JN, Bennett JH, Devlin C, Leboy PS and Owen ME (1992). Evidence for an inverse relationship between the differentiation of adipoc3tiic and osteogenic cells in rat marrow stromal cell cnltnres. J Cell Sci 102 (Pt 2) 341-351. 

Prockop DJ (1997). Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276 71-74. 

Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC. Suppression of allogeneic T-cell proliferation by human marrow stromal cells implications in transplantation. Transplantation2003 l 5 3 i9-391. 

The AhR is expressed in bone marrow stromal cells [14] and human hematopoietic stem cells [15] and upon agonist binding the receptor translocates to the nucleus, resulting in altered transcriptional expression such as increased CYPlAl [16] and resulting in reactive oxygen species [17]. Nonpharmaceutical compounds such as TCDD, benzo(a)pyrene and benzene have been shown to induce hematotoxicity using this mechanism in vivo and in vitro [18, 19]. 

Zhu. H.. Li. Y. and Trush, M.A. (1995) Characterizatoin of benzo[a]pyrene quinine-induced toxicity to primary cultured bone marrow stromal cells from DBA/2 mice potential role... 

Pereira, A. and Dean, B. (2006) Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells a potential in vitro system for the study of agranulocytosis. Biochemical Pharmacology, 71, 783—793. 

Bone marrow stromal cells Epithelial cells... 

NT035 Khaldoyanidi, S., L. Sikora, I. Orlovskaya, V. Matrosova, V. Kozlov, and P. Sriramarao. Correlation between nicotine-induced inhibition of hematopoiesis and decreased CD44 expression on bone marrow stromal cells. Blood 2001 98(2) 303-312. 

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