Research clinical

Baillie, T.A., Stable Isotopes Application in Pharmacology, Toxicology and Clinical Research, Macmillan, London, 1978. 

History. Detailed reviews of biological, chemical, and clinical research that led to the introduction of oral contraceptives are available in the scientific and medical literature (8,9). 

Alessandro Lecci, Carlo Alberto Maggi Clinical Research Dept (AL) and Direction (CAM) of Menarini Ricerche, Florence, Italy... 

Approximately 5%-10% of ethanol is excreted unchanged in the breath and urine. The blood-to-breath ratio of ethanol is 2,000 to 1, an important relationship that permits blood alcohol determination from expired air, providing the basis for the use of breath alcohol measurement for clinical, research, and forensic applications. 

Mason B, Goodman A Acamprosate new preclinical and clinical research. Presented at the 23rd Annual Scientific Meeting of the Research Society on Alcoholism, Denver, CO, June 24—29, 2000... 

Miller WR, Zweben A, DiClemente CC, et al Motivational Enhancement Therapy Manual A Clinical Research Guide for Therapists Treating Individuals With Alcohol Abuse and Dependence. Project MATCH Monograph Series, Vol 2 (NIH Publ No 94—3723). Rockville, MD, National Institute on Alcohol Abuse and Alcoholism, 1995b... 

Professor of Psychiatry Associate Scientific Director, Alcohol Research Center Assistant Dean for Clinical Research, University of Connecticut School of Medicine, Farmington, Connecticut... 

Software designed for general or specific use might be useless in the intended application sociologists, mathematicians, clinical researchers, and physicists, just to name a few user categories, all gather and analyze data, to be sure, but each one has particular data structures and hypotheses. Tests must be selected to fit the application. 

Gieger C, Deneke H, Pluck J. The future of text mining in genome-based clinical research. Biosilico 2003 1 97-102. 

In a tiny fraction of cases, a quick formula can be used. For most cases, the analysis uses an options tree, with one leaf per possible outcome. However, this falls prey to the curse of dimensionality —the number of leaves on the tree grows exponentially in the number of risk and decision dimensions considered. Thus only a limited, simple set of situations can be optimized in this way because one has to severely limit the decisions and risks that are considered. Tools available to help automate and simplify options analysis, widely used in pharmaceutical project evaluation, include Excel addons such as R1SK [11] and more graphically based solutions such as DPL [12]. Both of these support the creation and evaluation of decision trees and of influence diagrams Figure 11.2 shows a simple example of each of these. A primer in applied decision theory is Clemen s book Making Hard Decisions, other sources may be found in the website of James Vornov, Director of Clinical Research at Guildford Pharmaceuticals, a recent convert to decision theory for options analysis [13]. 

The Changing Role of Clinical Research Associates Patient Recruitment Reduced Time to Database Lock Management of Geographically Diverse Studies... 

Most e-Clinical software consists of integrated suites of applications that support the clinical research process, including various ways of data entry that include in-house data entry, remote data capture, batch data load, and scan forms. These suites enable customers to quickly and easily design studies, capture clinical data, and automate workflow. Some e-clinical software systems are also Internet based. 

Green JA. The EDC value proposition to the pharmaceutical industry. A detailed comparison of EDC versus paper model costs for four different clinical research projects (Phase I-IIIb). Datatrak International, Inc., 2001. 

Pogash RM, Haak T, Grella V, Zimmerman R, Doty L. Using the web for secnrely managing the asthma Clinical Research Network (ACRN) and the Childhood Asthma Research And Education (CARE) network. Controlled Clin Trials 2004 1.1.4 387-98(12). 

Shlay JC, Chaloner K et al (1998) Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy a randomized controlled trial. Terry Beim Community Programs for Clinical Research on AIDS. JAMA 280(18) 1590-1595... 

BATAVIA M (2001) Clinical research for health professionals, Boston, Buherworth Heinemarm. CAMPBELL M j, MACHiN D (1999) Medical statistics, New York, John Wiley Sons, Inc. CHOW s c, LIU j p (1998) Design and analysis of clinical trials. New York, John Wiley Sons, Inc. 

HULLEY s B, CUMMINGS s R (1988) Designing clinical research, Baltimore, Williams Wilkins. 

BATAVIA M (2001) Clinical research for health professionals, Boston, Butterworth Heinemaim. 

MORSE M A, CALIFF R M, SUGARMANN J (2001) Monitoring and ensuring safety during clinical research , JAMA, 285, 1201-5. 

NEWMAN T B, BROWNER s w, CUMMINGS s R, HULLEY s B (1988) Designing a new study 11. Cross-sectional and case-control studies, in Hulley S B and Cummings S R, Designing Clinical Research, Baltimore, Williams Wilkins, 75-86. 

Chicago Center for Clinical Research 515 N. State Street Chicago Illinois 60610 USA... 

Department of Clinical Research and Development, Astra Draco AB,... 

Clinical Research Center for Allergology and Rheumatology, National Hospital Organization, Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara, Kanagawa, Japan (139)... 

Division of Preclinical Neuroscience and Endocrinology Department of Basic and Clinical Research Research Institute of Scripps Clinic La Jolla, CA 92037... 

Effects In Humans. Neither postmortem nor functional cerebrospinal fluid (CSF) studies in humans provide firm evidence for similar, long-term damages or alterations to monoaminergic neurons in chronic stimulant abusers. In part, the lack of demonstrable neurochemical changes may well be due to the obvious preclusion of well-controlled prospective experimentation in humans, as well as to variability in critical variables (e.g., individual sensitivity or pattern of abuse) encountered in clinical research. Possible relationship of the various complications of stimulant abuse including hyperpyrexia, seizure, anoxia, and metabolic exhaustion to neuronal chromatolysis, terminal destruction, and monoamine and enzymatic depletion have not been systematically explored in human autopsy eases. It should be also noted that, under nonperturbed conditions, overt behavioral deficits are rare in... 

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